Interchangeability of Stress and Amphetamine in Sensitization

Antelman, Seymour M.; Eichler, Alan J.; Black, Cynthia A.; Kocan, Donna

doi:10.1126/science.7188649

Cited by 534 publications

(228 citation statements)

References 9 publications

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“…These tendencies are also likely to be associated with SSRI-induced attenuation of the expression of behavioral sensitization, because the repeated SAL treatment as repeated injection stress could augment the ability of amphetamines to induce abnormal behavior. This view seems to be supported by the previous observation (Antelman et al, 1980) indicating that repeated mild stress (tail pressure stress) resulted in an enhanced behavioral response to d-amphetamine.…”

Section: Discussionsupporting

confidence: 77%

Selective Serotonin Reuptake Inhibitors, Fluoxetine and Paroxetine, Attenuate the Expression of the Established Behavioral Sensitization Induced by Methamphetamine

Kaneko

Kashiwa

Ito

et al. 2006

Neuropsychopharmacol

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To obtain an insight into the development of a new pharmacotherapy that prevents the treatment-resistant relapse of psychostimulantinduced psychosis and schizophrenia, we have investigated in the mouse the effects of selective serotonin reuptake inhibitors (SSRI), fluoxetine (FLX) and paroxetine (PRX), on the established sensitization induced by methamphetamine (MAP), a model of the relapse of these psychoses, because the modifications of the brain serotonergic transmission have been reported to antagonize the sensitization phenomenon. In agreement with previous reports, repeated MAP treatment (1.0 mg/kg a day, subcutaneously (s.c.)) for 10 days induced a long-lasting enhancement of the increasing effects of a challenge dose of MAP (0.24 mg/kg, s.c.) on motor activity on day 12 or 29 of withdrawal. The daily injection of FLX (10 mg/kg, s.c.) or PRX (8 mg/kg, s.c.) from 12 to 16 days of withdrawal of repeated MAP administration markedly attenuated the ability of the MAP pretreatment to augment the motor responses to the challenge dose of the stimulant 13 days after the SSRI injection. The repeated treatment with FLX or PRX alone failed to affect the motor stimulation following the challenge of saline and MAP 13 days later. These results suggest that the intermittent and repetitive elevation of serotonergic tone may inhibit the expression of the motor sensitization induced by pretreatment with MAP. It is proposed that clinically available serotonin reuptake inhibitors could be useful for preventing the recurrence of hallucinatory-paranoid state in drug-induced psychosis and schizophrenia.

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Section: Discussionsupporting

confidence: 77%

Selective Serotonin Reuptake Inhibitors, Fluoxetine and Paroxetine, Attenuate the Expression of the Established Behavioral Sensitization Induced by Methamphetamine

Kaneko

Kashiwa

Ito

et al. 2006

Neuropsychopharmacol

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“…First, the available data show that the group differences in vulnerability and susceptibility to the behavioural effects of dexamphet amine become especially evident when the rats are exposed to intermediate doses of dexamphetamine (0,5-1.0 mg/kg, SC): group-specific differences are ab sent when either no dexamphetamine at all (water-treated rats) or high doses of dexamphetamine (2.0 mg/kg) are administered in the present experimental context. Given the finding that dexamphetamine and environmental challenges such as novelty are interchangeable in their effects (Antelman et al 1980), these data indicate that group-specific differences between HR and LR become especially manifest when they are exposed to intermedi ate, environmental or pharmacological challenges, but not when exposed to very small or very large challenges. These findings imply that differential responses of HR and LR are determined not only by different experimen tal conditions, but also by differences in experience.…”

Section: Ex Amphetamine-treated Hr and Lrmentioning

confidence: 99%

Differences in vulnerability and susceptibility to dexamphetamine in Nijmegen high and low responders to novelty: a dose-effect analysis of spatio-temporal programming of behaviour

Cools¹,

Ellenbroek²,

Gingras³

et al. 1997

Psychopharmacology

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Susceptibility to behavioural effects of dex amphetamine (0.5-2.0 mg/kg, SC) was analyzed in Ni jmegen high responders to novelty (HR) and Nijmegen low responders to novelty (LR), using an automated ethological analysis. The main results were that, first, dexamphetamine was more toxic in HR than LR: 5.0 mg/kg dexamphetamine was lethal in 75% HR, re spectively, 25% LR. Second, dexamphetamine had ef fects in HR at doses far lower than in LR; a dose of 0.5 or 1.0 mg/kg dexamphetamine was already sufficient to produce ceiling effects in HR, whereas a minimum dose of 2.0 mg/kg dexamphetamine was required to reach ef fects of a similar magnitude in LR. Third, the behaviour al responses to 2.0 mg/kg dexamphetamine did not differ between HR and LR. These data show that HR are both more vulnerable and more susceptible to the toxic and behavioural effects of intermediate doses of dexamphet amine than LR. It is concluded that knowledge acquired previously about the neurochemical differences between Nijmegen HR (APO-SUS) and Nijmegen LR (APO-UN-SUS) rats can be used to analyze further the mechanisms of action underlying individual-specific differences in drug abuse in animals and man.

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“…Heightened stress in abstinent cocaine users is associated with increased drug craving (Fox et al, 2005;Sinha, 2001), and exposure to acute stress during abstinence reliably elicits cocaine seeking in animal models of relapse (Erb et al, 1996(Erb et al, , 2001Sorge and Stewart, 2005). Moreover, stress contributes to the development of sensitization to cocaine (Post and Rose, 1976;Prasad et al, 1995;Meaney et al, 2002) and amphetamine (Antelman et al, 1980). Thus, stress is a significant risk factor in both the initiation of drug taking in drug-naive subjects, and relapse to drug use in abstinent cocaine addicts.…”

Section: Introductionmentioning

confidence: 99%

Rats with Extended Access to Cocaine Exhibit Increased Stress Reactivity and Sensitivity to the Anxiolytic-Like Effects of the mGluR 2/3 Agonist LY379268 during Abstinence

Aujla

Martin‐Fardon

Weiss

2007

Neuropsychopharmacol

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Metabotropic glutamate 2/3 receptors (mGluR2/3) are emerging targets for the reduction of stress that contributes to drug relapse. The effect of a history of cocaine escalation on stress reactivity during abstinence and the role of mGlu2/3 receptors in stress in these animals were tested. Experiment 1FRats trained to self-administer cocaine, under short (ShA, 1-h) or long (LgA, 6-h) access conditions, or noncaloric food pellets (Ctrl, 1-h), were tested for stress reactivity in the shock-probe defensive burying test following 1, 14, 42, or 84 days of abstinence. Experiment 2FExperimentally naive rats receiving the mGlu2/3 receptor agonist LY379268 (0, 0.3, 1.0, or 3.0 mg/kg) were tested in the defensive burying test to establish the anxiolytic efficacy of this compound in this model. Experiment 3FRats with a history of ShA vs LgA cocaine self-administration, or a history of operant responding reinforced by noncaloric food pellets, were tested in the defensive burying test, following administration of LY379268 (0.3, 1.0, or 3.0 mg/kg) at 14 days of abstinence. LgA rats exhibited a two-to threefold increase in defensive burying at 1, 14, and 42 days of abstinence compared to ShA or control animals. LY379268 (3.0 mg/kg) reduced burying in all groups, whereas the 1.0-mg/kg dose reduced burying only in the LgA group. A robust and enduring increase in stress reactivity developed in rats with a history of daily 6-h access to cocaine. The anxiolytic-like effects of LY379268 identify mGlu2/3 receptors as targets for ameliorating stress-associated relapse risk, and point toward the possibility that a history of cocaine escalation in rats may modify glutamatergic function.

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Interchangeability of Stress and Amphetamine in Sensitization

Cited by 534 publications

References 9 publications

Selective Serotonin Reuptake Inhibitors, Fluoxetine and Paroxetine, Attenuate the Expression of the Established Behavioral Sensitization Induced by Methamphetamine

Selective Serotonin Reuptake Inhibitors, Fluoxetine and Paroxetine, Attenuate the Expression of the Established Behavioral Sensitization Induced by Methamphetamine

Differences in vulnerability and susceptibility to dexamphetamine in Nijmegen high and low responders to novelty: a dose-effect analysis of spatio-temporal programming of behaviour

Rats with Extended Access to Cocaine Exhibit Increased Stress Reactivity and Sensitivity to the Anxiolytic-Like Effects of the mGluR 2/3 Agonist LY379268 during Abstinence

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