Interceptive Dentofacial Orthopedics (Growth Modification)

Caplin, Jennifer; Han, Michael; Allareddy, Veerasathpurush; Markiewicz, Michael R.

doi:10.1016/j.coms.2019.08.006

Cited by 5 publications

(4 citation statements)

References 57 publications

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“…Skeletal malocclusion is the most severe type of malocclusion since it is difficult to correct by orthodontic methods in adults; however, skeletal malocclusion can be corrected using orthopedic force when the patient is at their growth peak with unclosed sutures [ 1 ]. It has been reported that unclosed maxillofacial sutures can be remodeled using orthopedic force, and maxillofacial sutures are the residence of mesenchymal stem cells (MSCs) which participate in maxillofacial bone development and damage repair [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Gli1+ Cells Residing in Bone Sutures Respond to Mechanical Force via IP3R to Mediate Osteogenesis

Huang¹,

Liu

Wu³

et al. 2021

Stem Cells International

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Early orthodontic correction of skeletal malocclusion takes advantage of mechanical force to stimulate unclosed suture remodeling and to promote bone reconstruction; however, the underlying mechanisms remain largely unclear. Gli1+ cells in maxillofacial sutures have been shown to participate in maxillofacial bone development and damage repair. Nevertheless, it remains to be investigated whether these cells participate in mechanical force-induced bone remodeling during orthodontic treatment of skeletal malocclusion. In this study, rapid maxillary expansion (RME) mouse models and mechanical stretch loading cell models were established using two types of transgenic mice which are able to label Gli1+ cells, and we found that Gli1+ cells participated in mechanical force-induced osteogenesis both in vivo and in vitro. Besides, we found mechanical force-induced osteogenesis through inositol 1,4,5-trisphosphate receptor (IP3R), and we observed for the first time that inhibition of Gli1 suppressed an increase in mechanical force-induced IP3R overexpression, suggesting that Gli1+ cells participate in mechanical force-induced osteogenesis through IP3R. Taken together, this study is the first to demonstrate that Gli1+ cells in maxillofacial sutures are involved in mechanical force-induced bone formation through IP3R during orthodontic treatment of skeletal malocclusion. Furthermore, our results provide novel insights regarding the mechanism of orthodontic treatments of skeletal malocclusion.

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Section: Introductionmentioning

confidence: 99%

Gli1+ Cells Residing in Bone Sutures Respond to Mechanical Force via IP3R to Mediate Osteogenesis

Huang¹,

Liu

Wu³

et al. 2021

Stem Cells International

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“…Diupayakan posisi vertikal maksila dipertahankan dan erupsi gigi posterior atas dapat dicegah. 6 Namun ada pendapat berbeda yang menyimpulkan bahwa kasus gigitan terbuka yang betulbetul bersifat skeletal sangat mustahil untuk dirawat secara ortodonti, karena penutupan gigitan terbuka dengan mengekstrusi gigi anterior akan menghasilkan estetis wajah yang kurang baik terutama pada pasien yang gigi geligi dan gingivanya terlihat jelas. 16 Perawatan gigitan terbuka anterior yang bersifat skeletal umumnya dirawat secara ortodonti hanya gigi geliginya saja tanpa melibatkan jaringan lainnya.17 Namun demikian tidak sedikit yang dilaporkan kasus yang berhasil dirawat dengan baik meskipun beberapa diantaranya hasil perawatan tidak stabil.6,9…”

Section: A Long Face Syndrome (Pertumbuhan Vertikal Yang Berlebih)unclassified

Perawatan dini pada displasia vertikal (Tinjauan Pustaka)

Zen

2022

JKGT

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Vertical dysplasia in pediatric patients is divided into vertical overgrowth dysplasia and vertical growth deficiency dysplasia. Although it is still debated when to start treating vertical dysplasia, recently, there has been increasing interest in treating vertical dysplasia that sometimes accompanies cases of sagittal or transverse dysplasia. The clinical picture of vertical overgrowth dysplasia is generally manifested by a large anterior facial height, especially in the one-third anterior lower part of the face, sometimes accompanied by an anterior open bite. Treatment of children with vertical dysplasia, especially those with excessive vertical dysplasia, should be done early so the disorder does not get worse and can take advantage of the existing growth potential. Treatment of cases of vertical dysplasia must consider the nature of the abnormality, namely dental or skeletal abnormalities, morphological age, the direction of mandibular rotation, and the possibility of other dysplasia and existing etiological factors..

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“…Moreover, infants born very preterm may be exposed to intubation and tube feeding enhancing low tongue positioning. Consequently, identifying among factors linked to preterm birth those associated with maxillofacial growth anomalies may contribute to early diagnosis, thus facilitating timely interceptive orthodontic treatment (22).…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for High-Arched Palate and Posterior Crossbite at the Age of 5 in Children Born Very Preterm: EPIPAGE-2 Cohort Study

et al. 2022

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Introduction:Children born very preterm have an immature sucking reflex at birth and are exposed to neonatal care that can impede proper palate growth.ObjectivesWe aimed to describe the frequency of high-arched palate and posterior crossbite at the age of 5 in children born very preterm and to identify their respective risk factors.MethodsOur study was based on the data from EPIPAGE-2, a French national prospective cohort study, and included 2,594 children born between 24- and 31-week gestation. Outcomes were high-arched palate and posterior crossbite. Multivariable models estimated by generalized estimation equations with multiple imputation were used to study the association between the potential risk factors studied and each outcome.ResultsOverall, 8% of children born very preterm had a high-arched palate and 15% posterior crossbite. The odds of high-arched palate were increased for children with low gestational age (24–29 vs. 30–31 weeks of gestation) [adjusted odds ratio (aOR) 1.76, 95% confidence interval (CI) 1.17, 2.66], thumb-sucking habits at the age of 2 (aOR 1.53, 95% CI 1.03, 2.28), and cerebral palsy (aOR 2.18, 95% CI 1.28, 3.69). The odds of posterior crossbite were increased for children with pacifier-sucking habits at the age of 2 (aOR 1.75, 95% CI 1.30, 2.36).ConclusionsAmong very preterm children, low gestational age and cerebral palsy are the specific risk factors for a high-arched palate. High-arched palate and posterior crossbite share non-nutritive sucking habits as a common risk factor. The oro-facial growth of these children should be monitored.

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Interceptive Dentofacial Orthopedics (Growth Modification)

Cited by 5 publications

References 57 publications

Gli1+ Cells Residing in Bone Sutures Respond to Mechanical Force via IP3R to Mediate Osteogenesis

Gli1+ Cells Residing in Bone Sutures Respond to Mechanical Force via IP3R to Mediate Osteogenesis

Perawatan dini pada displasia vertikal (Tinjauan Pustaka)

Risk Factors for High-Arched Palate and Posterior Crossbite at the Age of 5 in Children Born Very Preterm: EPIPAGE-2 Cohort Study

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