1999
DOI: 10.1146/annurev.micro.53.1.525
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Intercellular Signaling During Fruiting-Body Development of Myxococcus xanthus

Abstract: The myxobacterium Myxococcus xanthus has a life cycle that is dominated by social behavior. During vegetative growth, cells prey on other bacteria in large groups that have been likened to wolf packs. When faced with starvation, cells form a macroscopic fruiting body containing thousands of spores. The social systems that guide fruiting body development have been examined through the isolation of conditional developmental mutants that can be stimulated to develop in the presence of wild-type cells. Extracellul… Show more

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Cited by 227 publications
(163 citation statements)
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“…10 5 organisms and embark on a communicative process of fruiting body formation. Functional motility and several stage-specific intercellular signal molecules are required to complete the developmental process (Shimkets 1999). Within the fruiting body, a minority of the population transforms from vegetative rods into tough, spherical spores.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…10 5 organisms and embark on a communicative process of fruiting body formation. Functional motility and several stage-specific intercellular signal molecules are required to complete the developmental process (Shimkets 1999). Within the fruiting body, a minority of the population transforms from vegetative rods into tough, spherical spores.…”
Section: Introductionmentioning
confidence: 99%
“…Myxococcus xanthus fruiting body development and sporulation result largely from the collective action of individuals within aggregate groups that generate a common pool of intercellular signals (Shimkets 1999). Such fruiting body development is conceptually similar to group pathogenic infections in which 'the exploitative rate of an individual parasite…is limited by the collective action of the coinfecting group' (Brown et al 2002, p. 402).…”
Section: Introductionmentioning
confidence: 99%
“…The prokaryotic soil bacterium Myxococcus xanthus [17,18] is one of the most intriguing examples for morphogenesis and pattern formation. Like the slime mold Dictyostelium discoideum, M. xanthus exhibits social behaviour and a complex developmental cycle.…”
mentioning
confidence: 99%
“…When M. xanthus cells are unable to find sufficient nutrients or in presence of prey [1], they enter a developmental process in which they aggregate in raised pigmented mounds, termed fruiting bodies. Within the fruiting bodies cells differentiate to form metabolically dormant spores [2].…”
Section: Motility Plays a Crucial Role In The Life-cycle Of Myxococcumentioning
confidence: 99%