Intercellular junctions between palisade nerve endings and outer root sheath cells of rat vellus hairs

Kaidoh, Toshiyuki; Inoué, Takao

doi:10.1002/(sici)1096-9861(20000515)420:4<419::aid-cne1>3.0.co;2-3

Cited by 21 publications

(13 citation statements)

References 26 publications

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“…Although numerous free nerve endings innervate the skin, researchers have not demonstrated that these neuro-epidermal connections are synapses. Electron microscopic observations of typical synapse-like features on neurons innervating the skin, such as invaginations with dense mitochondria, endoplasmic reticulum and the presence of dense core vesicles, and plasma membrane thickening on adjacent epidermal cells, has led to proposals that communication between skin and nerves may involve synaptic and nonsynaptic means (Chateau & Misery 2004, Kaidoh & Inoue 2000. One nonsynaptic mode of communication between the two cells is that skin keratinocytes may release specific signaling molecules upon thermal stimulation, which leads to the activation of receptors on sensory neurons .…”

Section: Thermosensation In Keratinocytes?mentioning

confidence: 99%

TRP Ion Channels and Temperature Sensation

Dhaka

Viswanath

Patapoutian

2006

Annu. Rev. Neurosci.

676

590

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The abilities to sense environmental and internal temperatures are required for survival, both for maintenance of homeostasis and for avoidance of tissue-damaging noxious temperatures. Vertebrates can sense external physical stimuli via specialized classes of neurons in the peripheral nervous system that project to the skin. Temperature-sensitive neurons can be divided into two classes: innocuous thermosensors (warm or cool) and noxious thermonociceptors (hot or cold). ThermoTRPs, a subset of the transient receptor potential family of ion channels, which are expressed in sensory nerve endings and in skin, respond to distinct thermal thresholds. In this review, we examine the extent to which thermoTRPs are responsible for providing a molecular basis for thermal sensation.

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Section: Thermosensation In Keratinocytes?mentioning

confidence: 99%

TRP Ion Channels and Temperature Sensation

Dhaka

Viswanath

Patapoutian

2006

Annu. Rev. Neurosci.

676

590

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“…Nerve fibres innervate skin in the interfollicular epidermis (IFE) and in the upper region of hair follicle . In the upper region, nerve endings dock to epidermal cells together with terminal Schwann cells, forming a specialized structure similar to the neuromuscular junction, enabling the hair follicle to sense the environment . The crosstalk between nerves and epidermal cells is important for morphogenesis and homeostasis .…”

Section: Introductionmentioning

confidence: 99%

Epidermal expression of Lgr6 is dependent on nerve endings and Schwann cells

Liao

Nguyen

2014

Experimental Dermatology

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Lgr5/6 proteins are stem cell markers in various tissues. However, what determines their restricted expression pattern in these tissues remains unknown. We found that in skin, Lgr6 is not only expressed in the central isthmus, directly above the hair follicle bulge cells as reported previously, but also in the interfollicular epidermis. Lgr6 expression in skin is highly correlated with the innervation sites of cutaneous nerves. In the hair follicle, Lgr6 closely localizes with the surrounding nerve endings and their corresponding Schwann cells throughout the entire hair cycle. Furthermore, ablation of cutaneous nerves leads to degeneration of Schwann cells and diminished expression of Lgr6. Our results demonstrate that the nerve endings/Schwann cells control Lgr6 expression in skin, implying that they play a role in regulation of skin epithelial cells.

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“…S1). Electron microscopy studies have shown that N-cadherinmediated adherens junctions are formed between outer root sheath (ORS) keratinocytes in the hair follicle and either tIISC processes or the terminal nerve endings themselves (Kaidoh and Inoue, 2000;Kaidoh and Inoue, 2008), suggesting that the maintenance of this receptor might rely on communication between all three cellular components. Some precedence for this concept has been demonstrated in the central nervous system where the excitatory neurotransmitter glutamate represents a major form of communication between neurons and glial cells (Alix and Domingues, 2011).…”

Section: Introductionmentioning

confidence: 99%

Excitatory glutamate is essential for development and maintenance of the piloneural mechanoreceptor

et al. 2012

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SUMMARYThe piloneural collar in mammalian hairy skin comprises an intricate pattern of circumferential and longitudinal sensory afferents that innervate primary and secondary pelage hairs. The longitudinal afferents tightly associate with terminal Schwann cell processes to form encapsulated lanceolate nerve endings of rapidly adapting mechanoreceptors. The molecular basis for piloneural development, maintenance and function is poorly understood. Here, we show that Nefh-expressing glutamatergic neurons represent a major population of longitudinal and circumferential sensory afferents innervating the piloneural collar. Our findings using a VGLUT2 conditional-null mouse model indicate that glutamate is essential for innervation, patterning and differentiation of NMDAR + terminal Schwann cells during piloneural collar development. Similarly, treatment of adult mice with a selective NMDAR antagonist severely perturbed piloneural collar structure and reduced excitability of these mechanosensory neurons. Collectively, these results show that DRG-derived glutamate is essential for the proper development, maintenance and sensory function of the piloneural mechanoreceptor.

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Intercellular junctions between palisade nerve endings and outer root sheath cells of rat vellus hairs

Cited by 21 publications

References 26 publications

TRP Ion Channels and Temperature Sensation

TRP Ion Channels and Temperature Sensation

Epidermal expression of Lgr6 is dependent on nerve endings and Schwann cells

Excitatory glutamate is essential for development and maintenance of the piloneural mechanoreceptor

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