Intercellular centrosome number is correlated with the copy number of chromosomes in bladder cancer

Yamamoto, Yoshiaki; Eguchi, Satoshi; Junpei, Akao; Nagao, Kazuhiro; Sakano, Shigeru; Furuya, Tomoko; Oga, Atsunori; Kawauchi, Shigeto; Sasaki, Kohsuke; Matsuyama, Hideyasu

doi:10.1016/j.cancergencyto.2009.01.012

Cited by 12 publications

(8 citation statements)

References 18 publications

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“…Pihan et al (23) observed that centrosomes were structurally and numerically abnormal in the majority of patients with PCa. Furthermore, bladder cancer samples frequently contain a number of centrosomes that are significantly increased as a result of cytokinesis failure (24). CIT is specifically required during the late stages of cytokinesis for the organization and function of the midbody (7,25).…”

Section: Discussionmentioning

confidence: 99%

High expression of citron kinase predicts poor prognosis of prostate cancer

et al. 2020

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Citron kinase (CIT) is a Rho-effector protein kinase that is associated with several types of cancer. However, the role of CIT in prostate cancer (PCa) is unclear. The current study utilized microarray data obtained from The Cancer Genome Atlas, which was analyzed via Biometric Research Program array tools. Additionally, reverse transcription-quantitative (RT-q)PCR was performed to compare the mRNA expression of CIT in PCa tissue and in benign prostatic hyperplasia. The protein expression of CIT was detected in a consecutive cohort via immunochemistry and CIT was screened as a potential oncogene in PCa. The results of RT-qPCR demonstrated that the mRNA expression of CIT was increased in PCa tissues. Furthermore, immunochemistry revealed that CIT protein expression was positively associated with age at diagnosis, Gleason grade, serum PSA, clinical T stage, risk group, lymph node invasion and metastasis. When compared with the low expression group, patients with a high CIT expression exhibited shorter survival rates, cancer specific mortalities (CSM) and biochemical recurrence (BCR). In addition, multivariate analysis revealed that CIT was a potential predictor of CSM and BCR. The results revealed that CIT is overexpressed during the malignant progression of PCa and may be a predictor of a poor patient prognosis.

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Section: Discussionmentioning

confidence: 99%

High expression of citron kinase predicts poor prognosis of prostate cancer

et al. 2020

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“…Interestingly this is correlated with an increase in chromosome numbers [48]. Centrosome abnormalities have been detected also in malignant biliary tract diseases.…”

Section: Bladder Cancermentioning

confidence: 93%

“…Breast and prostate cancer [45][46][47] Bladder cancer and Malignant biliary tract disease [48,49] Pancreatic cancer [50] Head and neck sguamous cell carcinoma Oral squamous carcinomas [51][52][53] Neuroectodermals tumours [54] these were found centrosome hyperamplification. Since the percentage is so high, it is implied that this could be used as a marker for HNSCC [51].…”

Section: Abnormalities In Centrosomes In Various Cancersmentioning

confidence: 99%

Cytokinesis and cancer

Sagona

Stenmark

2010

FEBS Letters

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a b s t r a c tCytokinesis is the final stage of cell division during which the two daughter cells separate completely. Although less well understood than some of the earlier phases of the cell cycle, recent discoveries have shed light on the mechanisms that orchestrate this process, including cleavage furrow formation, midbody maturation and abscission. One of the reasons why research on cytokinesis has been attracting increasing attention is the concept that failure of this process in mammals is associated with carcinogenesis. In this minireview, we will discuss the possible links between cytokinesis and cancer, and highlight key mechanisms that connect these processes.

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“…Forced overexpression of Aurora-A in urothelial cells induced CA, chromosome missegregation and aneuploidy 77. Bladder cancer cell lines harbouring Aurora-A and p53 overexpression display supernumerary centrosomes with an even number of chromosome copy number 78. In clinical studies, CA in bladder TCC specimens strongly correlates with concomitant occurrence of cyclin E overexpression and p53 inactivation 76, as well as cyclin D1 gene amplification 75.…”

Section: Centrosome Amplification In Solid Tumoursmentioning

confidence: 95%

A Clinical Overview of Centrosome Amplification in Human Cancers

Chan¹

2011

Int. J. Biol. Sci.

327

349

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The turn of the 21st century had witnessed a surge of interest in the centrosome and its causal relation to human cancer development - a postulate that has existed for almost a century. Centrosome amplification (CA) is frequently detected in a growing list of human cancers, both solid and haematological, and is a candidate "hallmark" of cancer cells. Several lines of evidence support the progressive involvement of CA in the transition from early to advanced stages of carcinogenesis, being also found in pre-neoplastic lesions and even in histopathologically-normal tissue. CA constitutes the major mechanism leading to chromosomal instability and aneuploidy, via the formation of multipolar spindles and chromosomal missegregation. Clinically, CA may translate to a greater risk for initiation of malignant transformation, tumour progression, chemoresistance and ultimately, poor patient prognosis. As mechanisms underlying CA are progressively being unravelled, the centrosome has emerged as a novel candidate target for cancer treatment. This Review summarizes mainly the clinical studies performed to date focusing on the mechanisms underlying CA in human neoplasia, and highlights the potential utility of centrosomes in the diagnosis, prognosis and treatment of human cancers.

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Intercellular centrosome number is correlated with the copy number of chromosomes in bladder cancer

Cited by 12 publications

References 18 publications

High expression of citron kinase predicts poor prognosis of prostate cancer

High expression of citron kinase predicts poor prognosis of prostate cancer

Cytokinesis and cancer

A Clinical Overview of Centrosome Amplification in Human Cancers

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