Intercellular and Cell-Matrix Interactions in Breast Carcinoma: The Present State of Problem

Мнихович, М В; Мишина, Е. C.; Bezuglova, T. V.; Буньков, К. В.

doi:10.17650/1994-4098-2018-14-1-20-27

Cited by 1 publication

(2 citation statements)

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“…TAF has been reported to be involved in tumor invasion and metastasis by induction of epithelialmesenchymal transition and secretion of TGFβ and hepatocyte growth factor. Tumor cells that undergo epithelial-mesenchymal transition are characterized by enhanced migratory and invasive properties, while losing adhesive ones [6,50]. A specific marker of TAF has been shown to be a fibroblast activation protein, which is a cell surface serine protease type II and exerts both dipeptidyl peptidase and endopeptidase activities with the ability to cleave gelatin and type I collagen [52].…”

Section: The Key Role Of Activated Fibroblasts Of Connective Tumor Ti...mentioning

confidence: 99%

“…The factors of the stromal microenvironment include the following complex: 1) non-tumor cells (endothelial pericytes, smooth muscle cells, fibroblasts, myofibroblasts (МFs)); 2) extracellular molecules, namely non-classical elements of the stroma (adhesion molecules, growth factors, hormones, proteins, enzymes, metabolites); 3) ECM (connective tissue elements, including collagen, elastic, argyrophilic fibers, as well as nerves) [5,6].…”

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Modern views on the role of main components of stroma and tumor microinvironment in invasion, migration and metastasis

2023

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Summary. The review presents modern ideas about tumor microenvironment, which most researchers recognize as the main “player” in tumor cell invasion, cell migration and metastasis. The current data on the main components of the stroma and the microenvironment, which play the role of the driving force in tumor progression, are analyzed. In particular, the review highlights the issues of origin, biological traits, phenotypic plasticity, functional heterogeneity of activated fibroblasts — myofibroblasts and tumor-associated fibroblasts, which in recent years have received much attention. Such components of the extracellular matrix proteome as collagen and matrix metalloproteinases are discussed in detail. They are mostly produced by activated fibroblasts and, on the one hand, initiate the development of desmoplasia due to type I collagen and, on the other hand, promote degradation of extracellular matrix proteins due to metalloproteinases, which generally leads to tissue remodeling that promotes tumor progression. Possibilities of using the most important indicators of extracellular matrix remodeling as potential markers and targets of clinical strategy are discussed.

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Section: The Key Role Of Activated Fibroblasts Of Connective Tumor Ti...mentioning

confidence: 99%

mentioning

confidence: 99%

Modern views on the role of main components of stroma and tumor microinvironment in invasion, migration and metastasis

2023

View full text Add to dashboard Cite

show abstract

Intercellular and Cell-Matrix Interactions in Breast Carcinoma: The Present State of Problem

Cited by 1 publication

References 20 publications

Modern views on the role of main components of stroma and tumor microinvironment in invasion, migration and metastasis

Modern views on the role of main components of stroma and tumor microinvironment in invasion, migration and metastasis

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