Intercellular Adhesion Molecule-1 on Rat Corneal Endothelium in Experimental Uveitis

Sakamoto, Taiji; Takahira, Ken-Ichi; Sanui, H; Kohno, Toshihiko; Inomata, Hajime

doi:10.1006/exer.1993.1031

Cited by 11 publications

(8 citation statements)

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“…It is highly probable that local cells, such as microglial cells, secrete cytokine like interleukin‐1beta (IL‐1β) or tumour necrosis factor alpha (TNFα), which would lead to localized upregulation of ICAM‐1. This would be similar to the mechanism that underlies the formation of keratic precipitates in which cells adhere via their ligands to the integrins of corneal endothelial cells (Sakamoto et al. 1993; Lahmar et al.…”

Section: Discussionmentioning

confidence: 71%

Secondary choriocapillaritis in infectious chorioretinitis

2013

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ABSTRACT.Purpose: To analyse the indocyanine green angiography (ICGA) patterns of hypofluorescence that are compatible with choriocapillaritis that occur secondarily to toxoplasmic retinochoroiditis (ToRC), ocular tuberculosis (including tuberculous choroiditis, TuCR and multifocal serpiginoid choroiditis, TMSC) and syphilitic chorioretinitis (SyCR). Methods: This was a single centre, retrospective case review study. Patients with a diagnosis of ToRC, TuCR, TMSC or SyCR were identified, their charts were reviewed and fundus photographs, fluorescein angiography (FA) and ICGA pictures were assessed. Results: Indocyanine green angiography was performed at the initial presentation in 63 of the 105 patients with ToRC, in 37 of the 38 patients with TuCR, in six of six patients with TMSC and in two of four patients with SyCR. The following four ICGA patterns indicated choriocapillaritis: extension of hypofluorescence beyond the hypofluorescence of the actual infectious focus as seen on fundus photography or FA (seen only in ToRC and TuCR); small dark dots around the infectious focus (seen only in ToRC); multiple 'confetti-like' hypofluorescent areas or hypofluorescent geographical confluent areas (seen only in TMSC); and widespread areas of nonperfusion visible only in ICGA (seen only in SyCR). Conclusions: Patients with secondary choriocapillaritis have distinct typical ICGA findings. ICGA is thus an important diagnostic tool that can provide an explanation for otherwise obscure visual loss and that might have diagnostic value for specific conditions like ToRC and SyCR.

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Section: Discussionmentioning

confidence: 71%

Secondary choriocapillaritis in infectious chorioretinitis

2013

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“…Similarly, aryl hydrocarbon-interacting protein 1 has already been identified as a novel autoantigen in cancer-associated retinopathy (CAR) (Dalin 2015). There is a lack of information regarding the association of ICAM-2 with uveitis although a high level of expression of its close member ICAM-1 has been reported in corneal endothelium in experimental anterior uveitis in rat (Sakamoto et al 1993). These results probably speculate a close association of these proteins with the progression of autoimmunity during uveitis.…”

Section: Discussionmentioning

confidence: 99%

Identification of unique proteins in vitreous fluid of patients with noninfectious uveitis

Kasudhan¹,

Sarkar²,

Gupta

et al. 2018

Acta Ophthalmologica

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“…They are mainly composed of monocytes, neutrophils, macrophages, and lymphocytes. 3,42,43 The upregulated chemokines CXCL2, CXCL8, and The protein concentrations of CCL2, CXCL2, IL-6, and CXCL2 in the IL-1␣/TNF-␣ group were significantly higher than those in the control group. CXCL2 production in the control group was undetectable at 12 hours.…”

Section: Discussionmentioning

confidence: 94%