Intercellular Adhesion Molecule-1 K469E Polymorphism and Risk of Coronary Artery Disease: A Meta-Analysis

Abstract

BackgroundIntercellular adhesion molecule-1 (ICAM-1) K469E polymorphism has been implicated in susceptibility to coronary artery disease (CAD). Several studies investigated the association of this polymorphism with CAD in different populations but the results were contradictory. A meta-analysis was conducted to assess the association between ICAM-1 K469E polymorphism and CAD susceptibility.Material/MethodsDatabases including PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and Weipu Database were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. A random-effects model was used.ResultsFifteen case-control studies including 3088 cases and 3466 controls were included. Overall, a significant association between ICAM-1 K469E polymorphism and CAD was observed in the dominant model (OR=1.80; 95% CI 1.62–2.01; P<0.00001; Pheterogeneity=0.40). In subgroup analysis by ethnicity, a significant association was found among Asians (OR=1.92; 95% CI 1.51–2.43; P<0.00001; Pheterogeneity=0.98) and among Caucasians (OR=1.64; 95% CI 1.30–2.08; P<0.0001; Pheterogeneity=0.04). In the subgroup analysis by age, a significant association was found among young patients (OR=1.46; 95% CI 1.10–1.93; P=0.008; Pheterogeneity=0.21) and old patients (OR=1.92; 95% CI 1.75–2.10; P<0.00001; Pheterogeneity=0.99).ConclusionsResults of this meta-analysis suggest that ICAM-1 K469E polymorphism confers a risk factor of CAD.

ICAM-1 gene rs5498 polymorphism decreases the risk of coronary artery disease

“…We think previous meta-analyses [ 41 , 42 ] had several limitations. First, Li et al [ 42 ] and Zou et al [ 43 ] falsely extracted genotype data from included studies. [ 7 , 26 , 30 , 32 ] For instance, the correct genotype numbers from a Chinese study by Shang et al [ 7 ] were as following: case, AA = 48, AG = 50, GG = 24; control, AA = 29, AG = 33, GG = 35, but unlike the extracted data of these previous meta-analyses.…”

“…[ 7 , 26 , 30 , 32 ] For instance, the correct genotype numbers from a Chinese study by Shang et al [ 7 ] were as following: case, AA = 48, AG = 50, GG = 24; control, AA = 29, AG = 33, GG = 35, but unlike the extracted data of these previous meta-analyses. [ 42 , 43 ] We also suspected the correctness of data from 2 studies. [ 30 , 32 ] Therefore, we re-conducted the meta-analysis combined with the correct data of these studies included by previous meta-analyses (not containing these new emerging studies).…”

“…We found that rs5498 polymorphism was associated with the decreased risk of CAD, which was in accord with our later results. Second, Li et al [ 42 ] did not include 9 studies, [ 9 , 15 , 18 , 21 , 22 , 24 , 25 , 27 , 31 ] while Zou et al [ 43 ] did not include 11 studies. [ 9 , 14 , 15 , 18 , 21 , 22 , 24 – 27 , 31 ] Actually, these studies conformed to the inclusion criteria.…”

Intercellular adhesion molecule 1 rs5498 polymorphism is associated with the risk of myocardial infarction

“…Several meta-analyses investigated the association between ICAM-1 rs5498 polymorphism and CAD before [ 26 – 29 ]. They all indicated that rs5498 polymorphism was a risk factor for CAD [ 26 – 29 ]. Among these meta-analyses, only one study by Li et al .…”