Intercellular Adhesion Molecule-1 K469E and Angiotensinogen T207M Polymorphisms in Coronary Slow Flow

Abstract

Objective: To investigate intercellular adhesion molecule-1 (ICAM1) and angiotensinogen (AGT) gene polymorphisms, as related to atherosclerosis and endothelial dysfunction, in coronary slow flow (CSF). Subjects and Methods: The participants in this study were 48 patients with CSF and 67 patients with normal coronary flow as controls. The K469E polymorphism of ICAM1 (rs5498) and the T207M polymorphism of AGT (rs4762) were determined using the polymerase chain reaction amplification method. Results: Baseline demographic parameters were similar in both groups. The mean thrombolysis in myocardial infarction frame count was significantly higher in patients with CSF (23.8 ± 5.1) compared to the controls (13.3 ± 2.6, p < 0.001). A significant association was found between the ICAM1 K allele and CSF (OR: 1.96, 95% CI: 1.15-3.35, p = 0.013). There was no difference in the frequency of AGT T207M genotypes in the patients with CSF and the control subjects. Conclusion: This study showed that K469E polymorphisms of ICAM1 that play a role in atherosclerotic pathogenesis are related to CSF.

Left Ventricular Twist Mechanics Are Impaired in Patients with Coronary Slow Flow

“…1 Although various mechanisms have been suggested for the pathogenesis of CSF, the pathophysiology and clinical implications of CSF are not clearly understood. [2][3][4] The effects of CSF, and subsequent inadequate blood supply, on myocardial functions are not known. Recent two-dimensional speckle tracking echocardiography (STE) and Doppler studies have shown that CSF results in systolic and diastolic dysfunctions.…”

ICAM-1 gene rs5498 polymorphism decreases the risk of coronary artery disease

“…Second, Li et al [ 42 ] did not include 9 studies, [ 9 , 15 , 18 , 21 , 22 , 24 , 25 , 27 , 31 ] while Zou et al [ 43 ] did not include 11 studies. [ 9 , 14 , 15 , 18 , 21 , 22 , 24 – 27 , 31 ] Actually, these studies conformed to the inclusion criteria. Third, Li et al identified a Chinese study, [ 46 ] but we did not find the genotype numbers of rs5498 polymorphism in this study.…”

Intercellular adhesion molecule 1 rs5498 polymorphism is associated with the risk of myocardial infarction

“…We thought our data were more robust than those of previous meta-analyses. More eligible studies were included in this meta-analysis [ 13 , 15 , 17 ]. In addition, the power analysis indicated that this meta-analysis had a power of 94.3% to detect the effect of rs5498 polymorphism on MI susceptibility with an OR of 0.60.…”