Intercalation of Ketoprofen into Mg-Al Hydrotalcites. Synthesis and Characterization

Abstract

Ketoprofen a non-steroidal anti-inflammatory drug was intercalated into Mg-Al hydrotalcites lamella as an inorganic host by different methods. The intercalation compounds were examined by X-ray diffraction (XRD), FTIR spectroscopy, differential thermal analysis and thermo gravimetric analysis. The XRD patterns of the samples the diffraction peaks are typical to those of well crystallized solids with the hydrotalcite structure. The FTIR spectroscopy and thermogravimetric (DTG) analysis point out the presence of the organic compound in the network structure of the synthesized hydrotalcites.

Thermal Behaviour of Some Pharmaceutical Products Containing Irbesartan, Comparing to the Active Substance

“…Thermal methods of analysis are of great importance for solving pharmaceutical problems such as purity determination, qualitative and quantitative analysis of drugs, determination of thermal stability and kinetic parameters [11,15,26]. Thermogravimetric (TG) analysis and differential scanning calorimetry (DSC) are used in the pharmaceutical industry to determine the purity of active substances [8,18]. Thermal instability of drugs affects the process of making tablets, the therapeutic efficacy, the toxicity and bioavailability [2,13,14].…”