Intercalated discs: cellular adhesion and signaling in heart health and diseases

Zhao, Guangze; Qiu, Ye; Zhang, Huifang M.; Yang, Decheng

doi:10.1007/s10741-018-9743-7

“…C). At least 200 different proteins are known to be associated with the ICD; mutation of at least 40% of these proteins are associated with different forms of cardiomyopathy . Intercellular proteins include desmosomal cadherins, desmoglein and desmocollin, while cytoplasmic proteins comprise desmoplakin, plakophilin and plakoglobin.…”

Section: Cardiomyocyte Proliferation and Intercalated Disc Junctionsmentioning

confidence: 99%

Cardiac regeneration and remodelling of the cardiomyocyte cytoarchitecture

Ali

¹

,

Braga

²

,

Giacca

³

2019

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Adult mammals are unable to regenerate their hearts after cardiac injury, largely due to the incapacity of cardiomyocytes (CMs) to undergo cell division. However, mammalian embryonic and fetal CMs, similar to CMs from fish and amphibians during their entire life, exhibit robust replicative activity, which stops abruptly after birth and never significantly resumes. Converging evidence indicates that formation of the highly ordered and stable cytoarchitecture of mammalian mature CMs is coupled with loss of their proliferative potential. Here, we review the available information on the role of the cardiac cytoskeleton and sarcomere in the regulation of CM proliferation. The actin cytoskeleton, the intercalated disc, the microtubular network and the dystrophin-glycoprotein complex each sense mechanical cues from the surrounding environment. Furthermore, they participate in the regulation of CM proliferation by impinging on the yes-associated protein/transcriptional co-activator with PDZ-binding motif, b-catenin and myocardin-related transcription factor transcriptional co-activators. Mastering the molecular mechanisms regulating CM proliferation would permit the development of innovative strategies to stimulate cardiac regeneration in adult individuals, a hitherto unachieved yet fundamental therapeutic goal.

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“…Second, the intercalated discs are irregular transverse thickenings of the sarcolemma that contain another type of adherens junctions called macula adherens, or desmosome (Zhao et al 2019). Desmosomes hold adjacent cardiac muscle fibers together during contraction by binding intermediate filaments (Delva et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Fine structure of the intercalated disc and cardiac junctions in the black widow spider Latrodectus mactans

Sun

¹

,

Lee

²

,

KU

³

et al. 2020

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Arthropods have an open circulatory system with a simple tubular heart, so it has been estimated that the contractile pumping structure of the cardiac muscle will be less efficient than that of vertebrates. Nevertheless, certain arthropods are known to have far superior properties and characteristics than vertebrates, so we investigated the fine structural features of intercalated discs and cardiac junctions of cardiac muscle cells in the black widow spider Latrodectus mactans. Characteristically, the spider cardiac muscle has typical striated features and represents a functional syncytium that supports multiple connections to adjacent cells by intercalated discs. Histologically, the boundary lamina of each sarcolemma connects to the basement membrane to form an elastic sheath, and the extracellular matrix allows the cells to be anchored to other tissues. Since the intercalated disc is also part of sarcolemma, it contains gap junctions for depolarization and desmosomes that keep the fibers together during cardiac muscle contraction. Furthermore, fascia adherens and macula adherens (desmosomes) were also identified as cell junctions in both sarcolemma and intercalated discs. To enable the coordinated heartbeat of the cardiac muscle, the muscle fibers have neuronal innervations by multiple axons from the motor ganglion.

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“…Second, the intercalated discs are irregular transverse thickenings of the sarcolemma that contain another type of adherens junctions called macula adherens, or desmosome (Zhao et al 2019). Desmosomes hold adjacent cardiac muscle bers together during contraction by binding intermediate laments (Delva et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Fine structure of the intercalated disc and cardiac junctions in the black widow spider Latrodectus mactans

Sun

¹

,

LEE

²

,

KU

³

et al. 2020

Preprint

0

View full text Add to dashboard Cite

Arthropods have an open circulatory system with a simple tubular heart, so it has been estimated that the contractile pumping structure of the cardiac muscle will be less efficient than that of vertebrates. Nevertheless, certain arthropods are known to have far superior properties and characteristics than vertebrates, so we investigated the fine structural features of intercalated discs and cardiac junctions of cardiac muscle cells in the black widow spider Latrodectus mactans. Characteristically, the spider cardiac muscle has typical striated features and represents a functional syncytium that supports multiple connections to adjacent cells by intercalated discs. Histologically, the boundary lamina of each sarcolemma connects to the basement membrane to form an elastic sheath, and the extracellular matrix allows the cells to be anchored to other tissues. Since the intercalated disc is also part of sarcolemma, it contains gap junctions for depolarization and desmosomes that keep the fibers together during cardiac muscle contraction. Furthermore, fascia adherens and macula adherens (desmosomes) were also identified as cell junctions in both sarcolemma and intercalated discs. To enable the coordinated heartbeat of the cardiac muscle, the muscle fibers have neuronal innervations by multiple axons from the motor ganglion.

show abstract

Intercalated discs: cellular adhesion and signaling in heart health and diseases

Cited by 55 publications

References 184 publications

Cardiac regeneration and remodelling of the cardiomyocyte cytoarchitecture

Cardiac regeneration and remodelling of the cardiomyocyte cytoarchitecture

Fine structure of the intercalated disc and cardiac junctions in the black widow spider Latrodectus mactans

Fine structure of the intercalated disc and cardiac junctions in the black widow spider Latrodectus mactans

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