Interanalyzer Analytical Variation of a High-Sensitivity Cardiac Troponin T Assay Can Exceed the Cutoff of the European Society of Cardiology 1-Hour Algorithm for Ruling Out Non–ST-Segment Elevated Myocardial Infarction

Flowers, Kade C.; Hunt, Clare; Collinson, Paul

doi:10.1093/clinchem/hvz037

Cited by 9 publications

(2 citation statements)

References 2 publications

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“…However, local verification of analytical performance is desirable, as not all instrumentation may necessarily achieve what is theoretically possible. 31 This can be remedied but usually requires close working with the manufacturer.…”

Section: Rapid Diagnostic Algorithms For Confirmation and Exclusion O...mentioning

confidence: 99%

Rapid diagnostic strategies using high sensitivity troponin assays: what is the evidence and how should they be implemented?

2022

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The introduction of high sensitivity measurement of cardiac troponin T (hs cTnT) and cardiac troponin I (hs cTnI) has given the laboratory the ability to measure very low levels of cardiac troponin. The limit of detection of these assays is well below the 99th percentile. These low levels can also be measured with small values of imprecision. A range of algorithms combining presentation measurement with very small repeat sample intervals, repeats at 1-2 hours have been developed. These are able to predict with acceptable accuracy the diagnosis that would be achieved with continued repeat sampling out to 6-12 hours from presentation. In this article we review the evidence for the diagnostic accuracy of these approaches and the practical aspects of implementation into routine clinical practice.

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Section: Rapid Diagnostic Algorithms For Confirmation and Exclusion O...mentioning

confidence: 99%

Rapid diagnostic strategies using high sensitivity troponin assays: what is the evidence and how should they be implemented?

2022

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“…In their recent letter to another journal, 1 Flowers et al. highlight the importance of ensuring that analytical precision (CV A ) is sufficient to meet the requirements of the European Society of Cardiology (ESC) guidelines 2 for rule-out of non-ST-segment elevation myocardial infarction (NSTEMI) using measurement of high-sensitivity cardiac troponin T (cTnT).…”

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confidence: 99%

Using the European Society of Cardiology 1-h algorithm for ruling out non-ST-segment elevated myocardial infarction to define acceptable analytical performance limits for a cardiac troponin T assay

Clifford-Mobley

2020

Ann Clin Biochem

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Analytical performance of cardiac troponin assays – Current status and future needs

Aakre

Saeed

et al. 2020

Clinica Chimica Acta

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Interanalyzer Analytical Variation of a High-Sensitivity Cardiac Troponin T Assay Can Exceed the Cutoff of the European Society of Cardiology 1-Hour Algorithm for Ruling Out Non–ST-Segment Elevated Myocardial Infarction

Cited by 9 publications

References 2 publications

Rapid diagnostic strategies using high sensitivity troponin assays: what is the evidence and how should they be implemented?

Rapid diagnostic strategies using high sensitivity troponin assays: what is the evidence and how should they be implemented?

Using the European Society of Cardiology 1-h algorithm for ruling out non-ST-segment elevated myocardial infarction to define acceptable analytical performance limits for a cardiac troponin T assay

Analytical performance of cardiac troponin assays – Current status and future needs

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