“…Dysregulated LD homeostasis is closely connected to many pathological conditions and the development of various diseases reactive oxygen species (ROS). peroxisome, organelles responsible for lipid oxidation, also have close association with LDs, and Plin5 has been identified to mediate the interaction between LD and mitochondria and may facilitate the transport of FA for oxidative phosphorylation with increased energy demand (Gao and Goodman, 2015;Lodhi and Semenkovich, 2014;Mason and Watt, 2015;Pu et al, 2011;Rambold et al, 2015;Schrader, 2001;Yu et al, 2015). LDs are also observed surrounding the nucleus or actually present in the nucleus that may function to store specific proteins or sequester transcriptional factors Welte, 2015).…”