“…In this issue, Stingl et al [12] introduce new clinical protocols for the evaluation of rod function which might be able to detect early efficacy signals. Similarly, Zollet et al [13] discuss a novel in vivo technique detecting apoptosis in the retina as a clinical endpoint to be used in early phase clinical development. The FDA previously stated in the setting of glaucoma that a statistically significant difference between groups on pointwise changes of at least 7 dB may be considered as clinically significant [14].…”