Interactive short-term effects of meteorological factors and air pollution on hospital admissions for cardiovascular diseases

He, Xuhua; Zhai, Shiyan; Liu, Huan; Liang, Liyang; Song, Genxin; Song, Hongquan; Kong, Yali

doi:10.1007/s11356-022-20592-5

Cited by 7 publications

(3 citation statements)

References 75 publications

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“…Our findings suggest that given the adverse health effects of low temperature, the synergy of low temperature and air pollution aggravates the impact on health. Previous studies have showed that the potential interactive effect of low temperature and air pollution exposure on cardiovascular diseases have been found. − More importantly, lower air temperatures and higher air pollution exposures often coexist due to extensive use of coal, wood, diesel, or oil burn for heating during the colder temperature in many parts of the world, e.g., China. These highlights that integrated climate and air quality policies should be formulated to strengthen the response to the combined health threats of temperature and air pollution.…”

Section: Resultsmentioning

confidence: 99%

Effects of Short- And Medium-Term Exposures to Lower Air Temperature on 71 Novel Biomarkers of Subclinical Inflammation: Results from the KORA F4 Study

Ni¹,

Breitner²,

Nikolaou³

et al. 2023

Environ. Sci. Technol.

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Increasing evidence has revealed that exposure to low temperatures is linked to a higher risk of chronic diseases and death; however, the mechanisms underlying the observed associations are still poorly understood. We performed a cross-sectional analysis with 1115 participants from the population-based KORA F4 study, which was conducted in Augsburg, Germany, from 2006 to 2008. Seventy-one inflammation-related protein biomarkers were analyzed in serum using proximity extension assay technology. We employed generalized additive models to explore short- and medium-term effects of air temperature on biomarkers of subclinical inflammation at cumulative lags of 0–1 days, 2–6 days, 0–13 days, 0–27 days, and 0–55 days. We found that short- and medium-term exposures to lower air temperature were associated with higher levels in 64 biomarkers of subclinical inflammation, such as Protein S100-A12 (EN-RAGE), Interleukin-6 (IL-6), Interleukin-10 (IL-10), C–C motif chemokine 28 (CCL28), and Neurotrophin-3 (NT-3). More pronounced associations between lower air temperature and higher biomarker of subclinical inflammation were observed among older participants, people with cardiovascular disease or prediabetes/diabetes, and people exposed to higher levels of air pollution (PM2.5, NO2, and O3). Our findings provide intriguing insight into how low air temperature may cause adverse health effects by activating inflammatory pathways.

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Section: Resultsmentioning

confidence: 99%

Effects of Short- And Medium-Term Exposures to Lower Air Temperature on 71 Novel Biomarkers of Subclinical Inflammation: Results from the KORA F4 Study

Ni¹,

Breitner²,

Nikolaou³

et al. 2023

Environ. Sci. Technol.

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“…However, of note, the roles of air pollutants in the relationship between temperature and morbidity or mortality have been heavily debated. While many studies included air pollution as confounding variables in the analysis, other studies investigated it as a co-exposure or effect modifier [60][61][62]. A systematic review did not summarize a modification effect on cardiovascular and respiratory mortality by PM 10 or O 3 but the results may vary by region [61].…”

Section: Discussionmentioning

confidence: 99%

Temperature and hospital admissions in the Eastern Mediterranean: a case study in Cyprus

Wang,

Achilleos,

Salameh

et al. 2024

Environ. Res.: Health

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Background:Exposure to extreme temperatures can trigger a cascade of adverse cardiovascular and respiratory events. However, in Cyprus, a hotspot of climate change in the Eastern Mediterranean region, little is known about the temperature-related cardiorespiratory morbidity risks.Methods:We analyzed daily counts of hospital admissions for cardiovascular and respiratory diseases from four general hospitals in three districts in Cyprus from 2000 through 2019. For each district, we fitted time-series quasi-Poisson regression with distributed lag non-linear models to analyze the associations between daily mean temperature (lag 0-21 days) and hospital admissions for cardiorespiratory, cardiovascular, and respiratory diseases. A random-effects meta-analytical model was then applied to pool the district-specific estimates and obtain the national average associations.Results:We analyzed 20 years of cause-specific hospitalization data with a total of 179,988 cardiovascular and respiratory events. The relationships between cardiorespiratory morbidity and temperature were overall U-shaped. During extreme temperature days, 15.85% (95% empirical CI [eCI]: 8.24, 22.40%) excess cardiovascular hospitalizations and 9.59% (95% eCI: -0.66, 18.69%) excess respiratory hospitalizations were attributable to extreme cold days (below the 2.5th percentile). Extreme hot days (above the 97.5th percentile) accounted for 0.17% (95% eCI: 0.03, 0.29%) excess cardiovascular hospitalizations and 0.23% (95% eCI: 0.07, 0.35%) excess respiratory hospitalizations.Conclusions:We found evidence of increased cardiovascular morbidity risk associated with extreme temperatures in Cyprus. Our study highlights the necessity to implement public health interventions and adaptive measures to mitigate the related temperature effects in an understudied region.

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“…Almost all of the world's population breathes air that exceeds the air quality guideline limit set by the World Health Organization (Perez Velasco & Jarosinska, 2022 ). Both long‐term and short‐term air pollution can cause a significant burden of disease, including an increased risk of hospitalization for CVD (Cohen et al., 2017 ; He et al., 2022 ). According to a study published in Journal of the American College of Cardiology, numerous studies have shown that air pollution and the development of CVD are generally correlated (Rajagopalan et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Association Between Air Pollution and Cardiovascular Disease Hospitalizations in Lanzhou City, 2013–2020: A Time Series Analysis

Yu,

Zhu,

Liu

et al. 2024

GeoHealth

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Extensive evidence has shown that air pollution increases the risk of cardiovascular disease (CVD) admissions. We aimed to explore the short‐term effect of air pollution on CVD admissions in Lanzhou residents and their lag effects. Meteorological data, air pollution data, and a total of 309,561 daily hospitalizations for CVD among urban residents in Lanzhou were collected from 2013 to 2020. Distributed lag non‐linear model was used to analyze the relationship between air pollutants and CVD admissions, stratified by gender, age, and season. PM2.5, NO2, and CO have the strongest harmful effects at lag03, while SO2 at lag3. The relative risks of CVD admissions were 1.0013(95% CI: 1.0003, 1.0023), 1.0032(95% CI: 1.0008, 1.0056), and 1.0040(95% CI: 1.0024, 1.0057) when PM2.5, SO2, and NO2 concentrations were increased by 10 μg/m³, respectively. Each 1 mg/m3 increase in CO concentration was associated with a relative risk of cardiovascular hospitalization of risk was 1.0909(95% CI: 1.0367, 1.1479). We observed a relative risk of 0.9981(95% CI: 0.9972, 0.9991) for each 10 μg/m³ increase in O3 for CVD admissions at lag06. We found a significant lag effects of air pollutants on CVD admissions. NO2 and CO pose a greater risk of hospitalization for women, while PM2.5 and SO2 have a greater impact on men. PM2.5, NO2, and CO have a greater impact on CVD admissions in individuals aged <65 years, whereas SO2 affects those aged ≥65 years. Our research indicates a possible short‐term impact of air pollution on CVD. Local public health and environmental policies should take these preliminary findings into account.

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Interactive short-term effects of meteorological factors and air pollution on hospital admissions for cardiovascular diseases

Cited by 7 publications

References 75 publications

Effects of Short- And Medium-Term Exposures to Lower Air Temperature on 71 Novel Biomarkers of Subclinical Inflammation: Results from the KORA F4 Study

Effects of Short- And Medium-Term Exposures to Lower Air Temperature on 71 Novel Biomarkers of Subclinical Inflammation: Results from the KORA F4 Study

Temperature and hospital admissions in the Eastern Mediterranean: a case study in Cyprus

Association Between Air Pollution and Cardiovascular Disease Hospitalizations in Lanzhou City, 2013–2020: A Time Series Analysis

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