The extent to which seismic amplitude maps can contribute to the analysis of hydrocarbon reservoirs was investigated for clastic and carbonate reservoirs worldwide. By using a petrophysical‐based, forward modeling process called incremental pay thickness (IPT) modeling, five lithology types were quantitatively analyzed for the interplay of seismic amplitude versus lithology, porosity, hydrocarbon pore fluid saturation, bedding geometries, and reservoir thickness. The studies identified three common tuning curve shapes (concave, convex, and bilinear) that were primarily dependent upon the lithology model type and the average net porosity therein. While the reliability of pay and porosity predictions from amplitude maps varied for each model type, all analyses showed a limited thickness range for which amplitude data could successfully predict net porosity thickness or hydrocarbon pore volume. The investigation showed that systematic forward modeling is required before amplitude maps can be properly interpreted.