This study aims to investigate the ability of an artificial neural network to differentiate between malign and benign skin lesions based on two statistics terms and for RGB (R red, G green, B blue) and YIQ (Y luminance, and I and Q chromatic differences) color spaces. The targeted statistics texture features are skewness (S) and kurtosis (K) which are extracted from the histograms of each color channel corresponding to the color spaces and for the two classes of lesions: nevi and melanomas. The extracted data is used to train the Feed-Forward Back Propagation Networks (FFBPNs). The number of neurons in the hidden layer varies: it can be 8, 16, 24, or 32. The results indicate skewness features computed for the red channel in the RGB color space as the best choice to reach the goal of our study. The reported result shows the advantages of monochrome channels representation for skin lesions diagnosis.