Interactive effects of n-TiO2 and 2,3,7,8-TCDD on the marine bivalve Mytilus galloprovincialis

Canesi, Laura; Frenzilli, Giada; Balbi, Teresa; Bernardeschi, Margherita; Ciacci, Caterina; Corsolini, Simonetta; Torre, Camilla Della; Fabbri, Rita; Faleri, Claudia; Focardi, Silvano; Guidi, Patrizia; Kočan, Anton; Marcomini, Antonio; Mariottini, Michela; Nigro, Marco; Pozo-Gallardo, Karla; Rocco, Lucia; Scarcelli, Vittoria; Smerilli, Arianna; Corsi, Ilaria

doi:10.1016/j.aquatox.2013.11.002

Cited by 129 publications

(93 citation statements)

References 78 publications

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“…Individuals located at the bottom of the tanks were likely experiencing higher TiO2NP exposure from settling particles, compared to individuals attached to the tank walls higher up. The Ti concentration in whole soft tissue (0.7 µg g -1 dw) in the low TiO2NP exposure group herein was comparable to Ti concentrations reported in M. galloprovincialis gill tissues (approximately 0.5 µg g -1 dw) after a 0.1 mg L -1 TiO2NP exposure (Canesi et al, 2014). In contrast to Canesi and coworkers (2014), who reported higher Ti accumulation in digestive glands compared to gills and other tissues, we found no significant differences in Ti concentrations between gill, digestive gland and rest of the mussel soft tissue.…”

Section: Discussionsupporting

confidence: 81%

The impact of TiO2 nanoparticles on uptake and toxicity of benzo(a)pyrene in the blue mussel (Mytilus edulis)

Farkas

Bergum

Nilsen

et al. 2015

Science of The Total Environment

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Nanoparticles are emerging contaminants of concern. Knowledge on their environmental impacts is scarce, especially on their interactive effects with other contaminants. In this study we investigated effects of titanium dioxide nanoparticles (TiO2NP) on the blue mussel (Mytilus edulis) and determined their influence on the bioavailability and toxicity of benzo(a)pyrene (B(a)P), a carcinogenic polyaromatic hydrocarbon (PAH). Blue mussels were exposed to either TiO2NP (0.2 and 2.0 mg L -1 ) or B(a)P (20 µg L -1 ) and to the respective combinations of these two compounds. Aqueous contaminant concentrations, the uptake of Ti and B(a)P into mussel soft tissue, effects on oxidative stress and chromosomal damage were analyzed. The uncoated TiO2NP agglomerated rapidly in the seawater. The presence of TiO2NP significantly reduced the bioavailability of B(a)P, shown by lowered B(a)P concentrations in exposure tanks and in mussel tissue. The activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were impacted by the various exposures regimes, indicating oxidative stress in the contaminant exposure groups. While SOD activity was increased only in the 0.2TiO2NP exposure group, CAT activity was enhanced in both combined exposure groups.The GPx activity was increased only in the groups exposed to the two single compounds. In hemocytes, increased chromosomal damage was detected in mussels exposed to the single compounds, which was further increased after exposure to the combination of compounds. In this study we show that the presence of TiO2NP in the exposure system reduced B(a)P uptake in blue mussels. However, since most biomarker responses did not decrease despite lower B(a)P uptake in combined exposures, the results suggest that TiO2NP can act as additional stressor, or potentially alters B(a)P toxicity by activation.

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Section: Discussionsupporting

confidence: 81%

The impact of TiO2 nanoparticles on uptake and toxicity of benzo(a)pyrene in the blue mussel (Mytilus edulis)

Farkas

Bergum

Nilsen

et al. 2015

Science of The Total Environment

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“…In contrast, several previous studies have reported enhanced bioavailability of organic toxicants to exposure organisms (e.g., tributyltin, BDE-209, DDT, TCDD) in the presence of n-TiO 2 [12,13,45,46], as n-TiO 2 acted as a carrier that enables compounds to adsorb on the organism surface. At the same time, adsorption and sedimentation also normally occurred in organic toxicants with n-TiO 2 in exposure media [12,46,51]. Thus, sedimentation does not appear to be the major reason that affects the bioavailability of organic toxicants by organisms.…”

Section: Discussionmentioning

confidence: 76%

“…Previous studies have reported that n-TiO 2 can adsorb heavy metals [4,34,44] or organic toxicants, including tributyltin, PBDEs, DDT and tetrachlorodibenzo-p-dioxin [TCDD] [12,13,45,46], while study showed the aggregation and subsequent sedimentation of nTiO 2 with tributyltin [12]. At the same time, we did not measure and (E) GSH content in larvae after exposure to PCP alone (0, 3, 10, and 30 g/L) and in the presence of n-TiO2 (0.1 mg/L) for 6 days.…”

Section: Discussionmentioning

confidence: 99%

Effect of titanium dioxide nanoparticles on the bioavailability, metabolism, and toxicity of pentachlorophenol in zebrafish larvae

Fang

Shi

Zhang

et al. 2015

Journal of Hazardous Materials

133

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“…Toxicity assessment of TiO 2 NPs has shown that they can induce cytotoxic, genotoxic and carcinogenic responses both in vitro and in vivo (Johnston et al, 2009;Trouiller et al, 2009;Chen et al, 2010;Kim et al, 2010;Canesi et al, 2014, Della Torre et al, 2015. The genotoxicity of fine TiO 2 -or TiO 2 whose particle size has not been defined-has been assessed in several earlier studies (Struwe et al, 2007;Türkez and Geyikoğlu, 2007;Türkez, 2008), but the information on the genotoxicity of nanosized TiO 2 is still scanty.…”

Section: Discussionmentioning

confidence: 98%

Genotoxicity assessment of TiO2 nanoparticles in the teleost Danio rerio

Rocco

Santonastaso

Mottola

et al. 2015

Ecotoxicology and Environmental Safety

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Interactive effects of n-TiO2 and 2,3,7,8-TCDD on the marine bivalve Mytilus galloprovincialis

Cited by 129 publications

References 78 publications

The impact of TiO2 nanoparticles on uptake and toxicity of benzo(a)pyrene in the blue mussel (Mytilus edulis)

The impact of TiO2 nanoparticles on uptake and toxicity of benzo(a)pyrene in the blue mussel (Mytilus edulis)

Effect of titanium dioxide nanoparticles on the bioavailability, metabolism, and toxicity of pentachlorophenol in zebrafish larvae

Genotoxicity assessment of TiO2 nanoparticles in the teleost Danio rerio

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