Interactive effects of MK-801 and morphine on EEG, EEG power spectra and behavior in rats: II. Morphine dependence

Haberny, Kathleen A.; Young, Gerald A.

doi:10.1016/0014-2999(94)90294-1

Cited by 2 publications

(1 citation statement)

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“…Involvement of glutamatergic neuroplasticity was also supported with observation in animal studies. For instance, the noncompetitive NMDA receptor blocker, MK-801 antagonized the changes of EEG spectral powers [55], and EPSP amplitudes of glutamatergic neurons synapsing to pyramidal neurons in the cortex were increased in rodents with chronic opioids [56]. In addition, chronic use of opioids sensitizes the expression of D 1 receptors on glutamatergic neurons in the basolateral amygdala that project to the cortex [56].…”

Section: Discussionmentioning

confidence: 99%

Estimating Mental Health Conditions of Patients with Opioid Use Disorder

Minnerly

Bressler

Shokry

et al. 2019

Journal of Addiction

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Objectives Noninvasive estimation of cortical activity aberrance may be a challenge but gives valuable clues of mental health in patients. The goal of the present study was to characterize specificity of electroencephalogram (EEG) electrodes used to assess spectral powers associated with mental health conditions of patients with opioid use disorder. Methods This retrospective study included 16 patients who had been diagnosed with opioid use disorder in comparison with 16 sex- and age-matched healthy controls. EEG electrodes were placed in the frontal (FP1, FP2, F3, F4, F7, F8, and Fz), central (C3, C4, and Cz), temporal (T3, T4, T5, and T6), parietal (P3, P4, and Pz), and occipital scalp (O1 and O2). Spectral powers of δ, θ, α, β, and γ oscillations were determined, and their distribution was topographically mapped with those electrodes on the scalp. Results Compared to healthy controls, the spectral powers at low frequencies (<8 Hz; δ and θ) were increased in most electrodes across the scalp, while powers at the high frequencies (>12 Hz; β and γ) were selectively increased only at electrodes located in the frontal and central scalp. Among 19 electrodes, F3, F4, Fz, and Cz were highly specific in detecting increases in δ, θ, β, and γ powers of patients with opioid use disorders. Conclusion Results of the present study demonstrate that spectral powers are topographically distributed across the scalp, which can be quantitatively characterized. Electrodes located at F3, F4, Fz, and Cz could be specifically utilized to assess mental health in patients with opioid use disorders. Mechanisms responsible for neuroplasticity involving cortical pyramidal neurons and μ-opioid receptor regulations are discussed within the context of changes in EEG microstates.

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Section: Discussionmentioning

confidence: 99%