Interactive effects of maternal and weaning high linoleic acid intake on hepatic lipid metabolism, oxylipins profile and hepatic steatosis in offspring

Marchix, Justine; Catheline, Daniel; Duby, Cécile; Monthéan-Boulier, Nathalie; Boissel, Françoise; Pédrono, Frédérique; Boudry, Gaëlle; Legrand, Philippe

doi:10.1016/j.jnutbio.2019.108241

Cited by 19 publications

(12 citation statements)

References 73 publications

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“…In parallel, the expression of several genes, among which IRS1, IR, PCTP, SCD5, and PPARα, as well as those involved in lipid metabolism was downregulated in CH and HH in this study. This is in agreement with data reported in rats, where a maternal high-LA diet was shown to lead to reduced hepatic mRNA expression of several genes involved in lipogenic pathway, srebp-1c (de novo lipogenesis), Scd-1 (conversion of SFA to MUFA), Fasn (FA synthase), and Elovl6 (FA elongase 6), and to affect the desaturation index ( 5 desaturase) (Marchix et al, 2020b). Thus, in rats, maternal HF diet during pregnancy was shown to alter the liver C16 desaturase pathway (Seet et al, 2015), as in this study with an increased 9 C16 desaturase index.…”

Section: Fetal Phenotypesupporting

confidence: 92%

Importance of Windows of Exposure to Maternal High-Fat Diet and Feto-Placental Effects: Discrimination Between Pre-conception and Gestational Periods in a Rabbit Model

et al. 2021

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Context and Aim: Lipid overnutrition in female rabbits, from prepuberty, leads to impaired metabolism (dyslipidemia and increased adiposity) and follicular atresia, and, when continued during gestation, affects offspring phenotype with intrauterine growth retardation (IUGR) and leads to placental and lipid metabolism abnormalities. Growth retardation is already observed in embryo stage, indicating a possible implication of periconceptional exposure. The objective of this study was to discriminate the effects of preconception and gestational exposures on feto-placental development.Materials and Methods: Rabbit 1-day zygotes were collected from female donors under control (CD) or high-fat-high-cholesterol (HD) diet and surgically transferred to the left and right uterus, respectively, of each H (n = 6) or C (n = 7) synchronized recipients. Close to term, four combinations, CC (n = 10), CH (n = 13), HC (n = 13), and HH (n = 6), of feto-placental units were collected, for biometry analyses. Fatty acid (FA) profiles were determined in placental labyrinth, decidua, fetal plasma, and fetal liver by gas chromatography and explored further by principal component analysis (PCA). Candidate gene expression was also analyzed by RT-qPCR in the placenta and fetal liver. Data were analyzed by Kruskal–Wallis followed by Dunn’s pairwise comparison test. Combinations of different data sets were combined and explored by multifactorial analysis (MFA).Results: Compared to controls, HH fetuses were hypotrophic with reduced placental efficiency and altered organogenesis, CH presented heavier placenta but less efficient, whereas HC presented a normal biometry. However, the MFA resulted in a good separation of the four groups, discriminating the effects of each period of exposure. HD during gestation led to reduced gene expression (nutrient transport and metabolism) and big changes in FA profiles in both tissues with increased membrane linoleic acid, lipid storage, and polyunsaturated-to-saturated FA ratios. Pre-conception exposure had a major effect on fetal biometry and organogenesis in HH, with specific changes in FA profiles (increased MUFAs and decreased LCPUFAs).Conclusion: Embryo origin left traces in end-gestation feto-placental unit; however, maternal diet during gestation played a major role, either negative (HD) or positive (control). Thus, an H embryo developed favorably when transferred to a C recipient (HC) with normal biometry at term, despite disturbed and altered FA profiles.

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Section: Fetal Phenotypesupporting

confidence: 92%

Importance of Windows of Exposure to Maternal High-Fat Diet and Feto-Placental Effects: Discrimination Between Pre-conception and Gestational Periods in a Rabbit Model

et al. 2021

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“…An additional consideration is the potential role of n-6 PUFAs on outcomes related to SARS-CoV-2 infection. N-6 PUFAs are highly abundant in the western diet and there is some suggestion that select n-6 PUFAs such as linoleic acid could be driving SPM deficiencies due to competition between the n-6 and n-3 fatty acids for specific enzymes that control SPM biosynthesis (65,66). This is particularly important to consider given that parenteral nutrition in a hospital setting is enriched in n-6 PUFA-enriched oils (67).…”

Section: Discussionmentioning

confidence: 99%

Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection

et al. 2020

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Obesity is a major independent risk factor for increased morbidity and mortality upon infection with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), which is responsible for the current coronavirus disease pandemic (COVID-19). Therefore, there is a critical need to identify underlying metabolic factors associated with obesity that could be contributing toward increased susceptibility to SARS-CoV-2 in this vulnerable population. Here, we focus on the critical role of potent endogenous lipid metabolites known as specialized pro-resolving mediators (SPMs) that are synthesized from polyunsaturated fatty acids. SPMs are generated during the transition of inflammation to resolution and have a vital role in directing damaged tissues to homeostasis; furthermore, SPMs display anti-viral activity in the context of influenza infection without being immunosuppressive. We cover evidence from rodent and human studies to show that obesity, and its co-morbidities, induce a signature of SPM deficiency across immunometabolic tissues. We further discuss how the effects of obesity upon SARS-CoV-2 infection are likely exacerbated with environmental exposures that promote chronic pulmonary inflammation and augment SPM deficits. Finally, we highlight potential approaches to overcome the loss of SPMs using dietary and pharmacological interventions. Collectively, this mini-review underscores the need for mechanistic studies on how SPM deficiencies driven by obesity and environmental exposures may exacerbate the response to SARS-CoV-2.

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“…The major genes that metabolize EPA and/or RvE1 are depicted by differing colors the biosynthesis of select SPM precursors. 40 Moreover, LA's consumption in the western diet is 14-18 times the amount required to prevent LA deficiency 2,41 and LA's effects on insulin sensitivity are debated. 42 LA is an essential signaling PUFA for human and animal health, but its overconsumption may contribute toward chronic inflammation and metabolic impairments.…”

Section: F I G U R Ementioning

confidence: 99%

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

et al. 2020

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Interactive effects of maternal and weaning high linoleic acid intake on hepatic lipid metabolism, oxylipins profile and hepatic steatosis in offspring

Abstract: Interactive effects of maternal and weaning high linoleic acid intake on hepatic lipid metabolism, oxylipins profile and hepatic steatosis in offspring.

Cited by 19 publications

References 73 publications

Importance of Windows of Exposure to Maternal High-Fat Diet and Feto-Placental Effects: Discrimination Between Pre-conception and Gestational Periods in a Rabbit Model

Importance of Windows of Exposure to Maternal High-Fat Diet and Feto-Placental Effects: Discrimination Between Pre-conception and Gestational Periods in a Rabbit Model

Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

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