Interactive Effects of Maternal Alcohol Problems and Parental Separation on Timing of Daughter's First Drink

Waldron, Mary; Watkins, Nicole K.; Bucholz, Kathleen K.; Madden, Pamela A. F.; Heath, Andrew C.

doi:10.1111/acer.13537

Cited by 10 publications

(4 citation statements)

References 42 publications

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“…Parental history of alcohol problems and parental separation before twins' age 18 were also modeled. Consistent with prior research (Waldron et al, 2012(Waldron et al, , 2014b(Waldron et al, , 2018, parental alcoholism was assessed from parent self-report of alcohol dependence, parental ratings of co-parent alcohol dependence symptoms, and twin ratings of each parent as a problem and excessive drinker, the latter assessed at Waves 1 and 4. Parental separation was assessed from parent and Waves 1, 3, 4, and 5 twin interviews.…”

Section: Methodsmentioning

confidence: 99%

Alcohol Dependence and Reproductive Onset in Women, Updated: Analyses of Research and State-Level Administrative Data

Waldron

Bucholz

Madden

et al. 2020

J. Stud. Alcohol Drugs

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The present study updates prior research, incorporating state-level administrative data to examine associations between self-reported history of alcohol dependence and birth recordderived reproductive onset, the latter assessed through peak childbearing years. Method: Participants included 542 African ancestry (AA) and 2,928 European or other ancestry (EA) female twins ascertained through Missouri birth records and recruited as part of a birth cohort study of like-sex female pairs born between 1975 and 1985. Analyses were limited to twins for whom residence in Missouri when of reproductive age could be documented, including twins who left Missouri but later returned. Cox proportional hazards regression models were estimated predicting age at first childbirth from history of alcohol dependence, separately for AA and EA twins, without and with adjustment for so-ciodemographic characteristics, comorbid psychopathology and other substance involvement, overweight/obesity status, and family-of-origin and childhood risk factors. Results: Among EA twins, alcohol dependence predicted both early and delayed childbearing; in adjusted models, alcohol dependence was associated with overall delayed childbearing. Associations between alcohol dependence and reproductive onset were nonsignificant among AA twins. Conclusions: Findings for EA twins are consistent with the broader literature indicating increased risk of teen motherhood associated with early-onset and problem drinking, but suggest that this may be explained by other correlated risk factors. The more robust finding, confirming relatively recent research, is of delayed childbearing associated with alcohol dependence.

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Section: Methodsmentioning

confidence: 99%

Alcohol Dependence and Reproductive Onset in Women, Updated: Analyses of Research and State-Level Administrative Data

Waldron

Bucholz

Madden

et al. 2020

J. Stud. Alcohol Drugs

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show abstract

“…Other studies have indicated no sex differences with regard to offspring’s risk for alcohol or substance disorders (Lieb et al, 2002; Mellentin et al, 2016). And yet, a recent study indicated that maternal alcohol problems among children of divorced parents was associated with a delayed onset of alcohol initiation among girls (Waldron et al, 2018).…”

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confidence: 99%

Parental Divorce and Family History of Alcohol Disorder: Associations with Young Adults’ Alcohol Problems, Marijuana Use, and Interpersonal Relations

Windle

2018

Alcoholism Clin & Exp Res

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“…Although the reasons why parental discord predicts both initiation of regular drinking and AUD but parental divorce only predicts initiation in the AA sample are unknown, it is consistent with some prior evidence that there are racial/ethnic differences in the effects of parental divorce on children’s outcomes, which have shown that the adverse effects tend to be weaker for African American/Black children than European American/White children ( Amato & Keith, 1991 ). The racial/ethnic disparities in how adverse family experiences influence alcohol use outcomes ( Waldron et al, 2018 ) may, in part, be attributable to differences in how children react to family stressors across diverse populations ( Cichy et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Association of parental divorce, discord, and polygenic risk with children's alcohol initiation and lifetime risk for alcohol use disorder

Kuo

Thomas

Alıev

et al. 2023

Alcohol: Clinical and Experimental Research

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Background: Parental divorce and discord are associated with poorer alcohol-related outcomes for offspring. However, not all children exposed to these stressors develop alcohol problems. Our objective was to test gene-by-environment interaction effects whereby children's genetic risk for alcohol problems modifies the effects of parental divorce and discord to predict alcohol outcomes. Methods: The sample included European (EA; N = 5608, 47% male, M age ~ 36 years) and African (AA; N = 1714, 46% female, M age ~ 33 years) ancestry participants from the Collaborative Study on the Genetics of Alcoholism. Outcomes included age at initiation of regular drinking and lifetime DSM-5 alcohol use disorder (AUD). Predictors included parental divorce, parental relationship discord, and offspring alcohol problems polygenic risk scores (PRS ALC ). Mixed effects Cox proportional hazard models were used to examine alcohol initiation and generalized linear mixed effects models were used to examine lifetime AUD. Tests of PRS moderation of the effects of parental divorce/relationship discord on alcohol outcomes were examined on multiplicative and additive scales.Results: Among EA participants, parental divorce, parental discord, and higher PRS ALC were associated with earlier alcohol initiation and greater lifetime AUD risk. Among AA participants, parental divorce was associated with earlier alcohol initiation and discord was associated with earlier initiation and AUD. PRS ALC was not associated with either. Parental divorce/discord and PRS ALC interacted on an additive scale in the EA sample, but no interactions were found in AA participants.Conclusions: Children's genetic risk for alcohol problems modifies the impact of parental divorce/discord, consistent with an additive model of diathesis-stress interaction, with some differences across ancestry.

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Interactive Effects of Maternal Alcohol Problems and Parental Separation on Timing of Daughter's First Drink

Cited by 10 publications

References 42 publications

Alcohol Dependence and Reproductive Onset in Women, Updated: Analyses of Research and State-Level Administrative Data

Alcohol Dependence and Reproductive Onset in Women, Updated: Analyses of Research and State-Level Administrative Data

Parental Divorce and Family History of Alcohol Disorder: Associations with Young Adults’ Alcohol Problems, Marijuana Use, and Interpersonal Relations

Association of parental divorce, discord, and polygenic risk with children's alcohol initiation and lifetime risk for alcohol use disorder

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