Interactive effects of experience and olfactory bulb lesions in male rat copulation

Bermant, Gordon; Taylor, Leanne S.

doi:10.1016/0031-9384(69)90005-5

Cited by 89 publications

(24 citation statements)

References 7 publications

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“…60616 Past attempts to assess the importance of olfaction for the occurrence of mating hehavior in male rodents have depended upon bilateral olfactory bulb ablation as the only reliable method for inducing anosmia. The results of experiments using this technique indicate the existence of species differences with respect to the importanee of olfaction for masculine mating b ehavior, In male rats, bulbectomy produces a deficit that varies in severity as a function of the amount of preoperative sexual experience and as a funetion of characteristics of the postoperative tests of mating behavior (Beach, 1942;Heimer & Larsson, 1967;Bermant & Taylor, 1969). On the other hand, in sexually experienced male hamsters an d mice, bulbectomy totally abolishes mating behavior (Murphy & Schneider, 1970;Rowe & Edwards, 1972).…”

Section: Effects Of Peripherally Induced Anosmia On Mating Behavior Omentioning

confidence: 88%

Effects of peripherally induced anosmia on mating behavior of male mice

Rowe

Smith

1972

Psychon Sci

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Section: Effects Of Peripherally Induced Anosmia On Mating Behavior Omentioning

confidence: 88%

Effects of peripherally induced anosmia on mating behavior of male mice

Rowe

Smith

1972

Psychon Sci

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“…Thus, female mice and hamsters fail to build nests or display maternal care following bilateral olfactory bulbectomy (Gandelman et al, 1971(Gandelman et al, , 1972Zarrow et al, 1971;Vandenbergh, 1973;Marques, 1979). The bilateral removal of the olfactory bulbs retards copulatory behavior in male rats (Heimer and Larsson, 1967;Bermant and Taylor, 1969;Larsson, 1971) and in females of a variety of rodent species (Moss, 1971;Thompson and Edwards, 1972;Edwards and Burge, 1973;Vandenbergh, 1973). Indeed, such lesions completely eliminate sexual behavior in male hamsters (Murphy and Schneider, 1970;Winans and Powers, 1974) and male mice (Rowe and Edwards, 1972;Rowe and Smith, 1973;Edwards, 1974).…”

Section: Introductionmentioning

confidence: 99%

Sexual behavior and aggression in male mice: involvement of the vomeronasal system

Clancy¹,

Coquelin²,

Macrides³

et al. 1984

J. Neurosci.

168

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Recent observations have implicated the vomeronasal (accessory olfactory) system in the chemosensory control of rodent social behaviors. The purpose of this study was to observe the effects of peripheral vomeronasal organ extirpation on sexual behavior, aggression, and urine marking in male mice. Relative to sham-operated control animals, mice lacking vomeronasal organs displayed significantly reduced levels of copulatory behavior and intermale aggression. Urine marking rates were not reduced. The peripheral removal of the vomeronasal organ resulted in complete bilateral deafferentation of the accessory olfactory bulbs but spared the peripheral input to the main olfactory bulbs as evidenced by the lack of anterograde vomeronasal nerve transport but normal anterograde olfactory nerve transport of intranasally applied horseradish peroxidase. Neither body weights, paired testes weights, nor seminal vesicle weights of mice with vomeronasal system lesions differed significantly from those of control animals. Thus, an intact vomeronasal organ is important for the normal display of sexual behavior and aggression in male mice, and the reductions in these androgen-dependent behaviors following peripheral deafferentation of the vomeronasal system cannot be attributed to a chronic reduction of gonadal hormone secretion.Chemosensory stimuli and the olfactory system influence reproductive physiology and behavior in a broad range of mammalian species.

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“…Bilateral removal of the olfactory bulbs immediately and permanently abolishes sexual behavior (Murphy and Schneider, 1970). By contrast, olfactory bulbectomy does not eliminate copulation in sexually experienced male rats (Bermant and Taylor, 1969). However, olfactory bulbectomy has been used as a model of depression in rats (Kelly et al, 1997), and depression is known to alter DA release (Yadid et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Chemosensory Cues are Essential for Mating-Induced Dopamine Release in MPOA of Male Syrian Hamsters

Triemstra

Nagatani

Wood

2005

Neuropsychopharmacol

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The medial preoptic area (MPOA) is crucial for male sex behavior. Dopamine (DA) is released in MPOA during copulation, and contributes to the reinforcing effects of mating. The aim of the present study was to identify sensory stimuli responsible for matinginduced DA release. Specifically, we determined if chemosensory cues are essential for mating-induced MPOA DA release using in vivo microdialysis in male Syrian hamsters. Hamsters were used because chemosensory cues from the olfactory mucosa and vomeronasal organ are essential for sexual behavior in this species. Sexually experienced adult male hamsters were implanted with a microdialysis guide cannula over MPOA. At the same time, males received sham olfactory bulbectomy (Sham Bx, n ¼ 11), bilateral bulbectomy (Bibx, n ¼ 6), or unilateral bulbectomy (Ubx) ipsilateral (Ipsi Ubx, n ¼ 9) or contralateral (Contra Ubx, n ¼ 8) to the microdialysis probe. This model takes advantage of the predominantly ipsilateral projections of the olfactory bulbs. Microdialysis samples were collected from the MPOA during baseline, exposure to a receptive female, and after removal of female. Extracellular DA was measured using highperformance liquid chromatography with electrochemical detection. During mating, DA increased in MPOA of Sham Bx males (to 146.7717.5% of baseline). Bibx males did not mate, and MPOA DA did not increase (96.1715.8% of baseline). Although both groups of Ubx males mated to ejaculation, MPOA DA increased significantly only in Contra Ubx males (to 161.8735.3% of baseline), and not in males with Ipsi Ubx (107.6711.5% of baseline). The results demonstrate that chemosensory cues are essential for MPOA DA release during mating in male Syrian hamsters.

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Interactive effects of experience and olfactory bulb lesions in male rat copulation

Cited by 89 publications

References 7 publications

Effects of peripherally induced anosmia on mating behavior of male mice

Effects of peripherally induced anosmia on mating behavior of male mice

Sexual behavior and aggression in male mice: involvement of the vomeronasal system

Chemosensory Cues are Essential for Mating-Induced Dopamine Release in MPOA of Male Syrian Hamsters

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