Interactive effects of brain catecholamines and variations in sexual and non-sexual arousal on copulatory behavior of male rats

Caggiula, Anthony R.; Shaw, David H.; Antelman, Seymour M.; Edwards, David J.

doi:10.1016/0006-8993(76)90777-0

Cited by 83 publications

(20 citation statements)

References 31 publications

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“…The partial nigral destruction that did occur was, however, apparently sufficient to impair arousal-dependent parameters of the masculine mating pat tern (e.g. ejaculation latency), an effect that resembles that observed by Caggiula et al [4] following intracerebroventricular 6-OHDA infusions and probably reflects reduced responsiveness to sex-related stimuli emanating from the estrous female.…”

Section: Discussionmentioning

confidence: 66%

The Importance of the Peripeduncular Nucleus in the Neuroendocrine Control of Sexual Behavior and Milk Ejection in the Rat

Hansen

Køhler

1984

Neuroendocrinology

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Electrocoagulations situated in the lateral midbrain tegmentum cause severe deficits in sexual behavior and lactational performance of rats. In this study we determined the extent to which these effects could be reproduced by axon-sparing lesions using the excitotoxin, ibotenic acid; in another group of rats, 6-OHDA was infused in the same area to degenerate the mesencephalic catecholamine neuronal elements affected by the electrocoagulations. It was found that ibotenic acid, but not 6-OHDA, reproduced most of the effects produced by electrolytic lesions. Thus, female rats bearing ibotenic acid lesions showed little sexual receptivity and proceptivity in response to estrogen and progestin treatment, and the milk ejection reñex appeared nonfunctional following the lesion. Ibotenic acid-infused male rats failed to ejaculate on most postoperative observations, though they continued to mount he estrous female. Examination of the lesions with immunohistochemical visualization of tyrosine-hydroxylase- and substance P-positive neurons, and thionine staining, revealed that the neurotoxins exhibited the intended selectivity, though the ibotenic acid lesions were associated with loss of substance P-immunoreactive nerve terminals in the substantia nigra and the peripeduncular region. It is suggested that the peripeduncular nucleus plays an important role in the neuroendocrine control of male and female copulatory behavior, as well as in the regulation of the milk ejection reflex.

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Section: Discussionmentioning

confidence: 66%

The Importance of the Peripeduncular Nucleus in the Neuroendocrine Control of Sexual Behavior and Milk Ejection in the Rat

Hansen

Køhler

1984

Neuroendocrinology

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“…Stimuli emitted by the female could also be critical for our low-active animals. The study by Caggiula et al (1976), where intraventricular 6-OHDA + intraperitoneal a-methyl-p-tyrosine were found to reduce sexual behavior support a role for dopamine in arousal processes. In animals not copulating after the drug treatments, sexual behavior was easily induced by tail pinch.…”

Section: Discussionmentioning

confidence: 88%

“…Furthermore, depletion of brain catecholamines with 6-OH-dopamine inhibits sexual activity (Caggiula et al, 1976;Mclntosh and Barfield, 1984;Rodriquez et al, 1984).…”

Section: Introductionmentioning

confidence: 98%

Dopamine and sexual behavior in the male rat: a reevaluation

Ågmo

Fernández

1989

J. Neural Transmission

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In castrated male rats treated with a low dose of testosterone propionate (0.40 mg/kg per week), the dopamine agonists amphetamine and amfonelic acid reduced mount latency without affecting other aspects of sexual behavior. Apomorphine, in doses between 0.05 and 0.15 mg/kg, and 1-DOPA 5-45 mg/kg + carbidopa 50 mg/kg, lacked effect on sexual behavior. Both amphetamine and amfonelic acid increased locomotor activity in a dose-dependent manner. Apomorphine, in the lowest dose, produced a reduction whereas the higher doses of this drug as well as all doses of 1-DOPA lacked effect on this behavior. In castrated animals implanted with a testosterone-filled Silastic capsule, showing a level of sexual activity indistinguishable from that of intact animals, amphetamine and amfonelic acid did not affect sexual behavior. The dopamine receptor antagonists haloperidol and cis(Z)-flupentixol reduced sexual behavior, whereas pimozide was without effect in the dose range used. The doses of haloperidol and flupentixol that were required to reduce sexual activity were such that they also affected motor execution measured in a treadmill test. It is suggested that increased dopaminergic neurotransmission may stimulate sexual behavior in an indirect way, augmenting behavioral arousal. The inhibitory effects of dopamine antagonists could be explained either by a reduced arousal level or by motor deficiencies.

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“…This is also the case in castrated males given low testosterone doses (Hlinak et al, 1979;Hlinak and Madlafousek, 1982). Furthermore, different kinds of central nervous lesions render male rat sexual behavior dependent on female paracopulatory behavior (Caggiula et al, 1976;Edwards and Maillard, 1988;Whishaw and Kolb, 1985). It would appear, then, that female paracopulatory behavior is important only in situations where male sexual activity either has been reduced by specific experimental manipulations or in animals lacking sexual experience.…”

Section: Introductionmentioning

confidence: 95%