Interactive effect of sevoflurane with isradipine or indomethacin on spontaneous contractile activity of isolated pregnant rat myometrium

Gürsoy, Sinan; Kaya, Tijen; Kunt, Nur; Karadaş, Barış; Bağcıvan, İhsan; Kafali, Haluk

doi:10.1016/j.ijoa.2004.03.011

Cited by 4 publications

(2 citation statements)

References 31 publications

(31 reference statements)

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“…The effect of drugs on myometrium contraction has been studied using isolated myometrial strips from humans [9,10] and rats [11,12]. The amplitude and frequency have traditionally been used as an index of myometrium contraction because they can be easily measured from analog data.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, new computer software has made it possible to calculate the AUC [13][14][15]. Previous studies have found that sevofl urane reduces both the amplitude and frequency of myometrium contractions in myometrium isolated from humans [9,10] and rats [11,12]. Sevofl urane-induced myometrial relaxation has also been established using the AUC [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

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Inhibitory effect of alprostadil against sevoflurane-induced myometrial relaxation in rats

2007

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of alprostadil against sevoflurane-induced myometrial relaxation in rats

2007

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Sevoflurane exposure during the second trimester induces neurotoxicity in offspring rats by hyperactivation of PARP-1

Jiang

Zhao

2022

Psychopharmacology

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Mid-gestational sevoflurane exposure inhibits fetal neural stem cell proliferation and impairs postnatal learning and memory function in a dose-dependent manner

Wang

Yin

Xue

et al. 2018

Developmental Biology

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Advancements in fetal intervention procedures have led to increases in the number of pregnant women undergoing general anesthesia during the second trimester-a period characterized by extensive proliferation of fetal neural stem cells (NSCs). However, few studies have investigated the effects of mid-gestational sevoflurane exposure on fetal NSC proliferation or postnatal learning and memory function. In the present study, pregnant rats were randomly assigned to a control group (C group), a low sevoflurane concentration group (2%; L group), a high sevoflurane concentration group (3.5%; H group), a high sevoflurane concentration plus lithium chloride group (H + Li group), and a lithium chloride group (Li group) at gestational day 14. Rats received different concentrations of sevoflurane anesthesia for 2 h. The offspring rats were weaned at 28 days for behavioral testing (i.e., Morris Water Maze [MWM]), and fetal brains or postnatal hippocampal tissues were harvested for immunofluorescence staining, real-time PCR, and Western blotting analyses in order to determine the effect of sevoflurane exposure on NSC proliferation and the Wnt/β-catenin signaling pathway. Our results indicated that maternal exposure to 3.5% sevoflurane (H group) during the mid-gestational period impaired the performance of offspring rats in the MWM test, reduced NSC proliferation, and increased protein levels of fetal glycogen synthase kinase-3 beta (GSK-3β). Such treatment also decreased levels of β-catenin protein, CD44 RNA, and Cyclin D1 RNA relative to those observed in the C group. However, these effects were transiently attenuated by treatment with lithium chloride. Conversely, maternal exposure to 2% sevoflurane (L group) did not influence NSC proliferation or the Wnt signaling pathway. Our results suggest that sevoflurane exposure during the second trimester inhibits fetal NSC proliferation via the Wnt/β-catenin pathway and impairs postnatal learning and memory function in a dose-dependent manner.

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Interactive effect of sevoflurane with isradipine or indomethacin on spontaneous contractile activity of isolated pregnant rat myometrium

Cited by 4 publications

References 31 publications

Inhibitory effect of alprostadil against sevoflurane-induced myometrial relaxation in rats

Inhibitory effect of alprostadil against sevoflurane-induced myometrial relaxation in rats

Sevoflurane exposure during the second trimester induces neurotoxicity in offspring rats by hyperactivation of PARP-1

Mid-gestational sevoflurane exposure inhibits fetal neural stem cell proliferation and impairs postnatal learning and memory function in a dose-dependent manner

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