Interactive Effect of IGF2BP2 rs4402960 Variant, Smoking and Type 2 Diabetes

Abstract

Purpose: Genetic and environmental factors are related to type 2 diabetes (T2D). Genetic modifiers of T2D have not been widely determined among smoking individuals. In this population-based study, we investigated the interactive association between rs4402960 polymorphism of the insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) gene and smoking with T2D among Taiwanese adults. Materials and Methods: We obtained genetic data collected between 2008 and 2018 for 22,039 participants (aged 30-70 years) from the Taiwan Biobank (TWB) database. These data were analyzed using the t-test, Chi-square (χ 2 ) test, and multiple logistic regression. Results: The mean ages for participants with and without diabetes were 58.11±8.75 and 48.58±11, respectively. Compared with the rs4402960 GG genotype, the odds ratio (OR) for T2D was 1.261 among GT and 1.545 among TT genotype individuals (p<0.05). Current smokers compared to nonsmokers were associated with a higher risk of T2D (OR=1.266, p=0.0404). There was a significant interaction between the IGF2BP2 rs4402960 variant and smoking on T2D (p = 0.0497). After stratification by rs4402960 genotypes and smoking status, the OR was substantial only in current smokers with GG genotype (OR, 1.663, p = 0.0008). Conclusion:This population-based study indicated that the risk for T2D was stronger among current smoking rs4402960 GG individuals recruited between 2008 and 2019 in Taiwan.

Association of common variants in the IGF2BP2 gene with type 2 diabetes

“…Benrahma et al observed a significant correlation between IGF2BP2 rs4402-960 polymorphism and diabetes under additive 2 and recessive models ( 23), but in a previous report in a Moroccan population, Saxena et al stated that there was no association of this SNP with diabetes (p = 0.22) (24). Additionally, the T allele frequency was 37.66% in controls, like the frequency found in South Asians (32%), Europeans (31%), and East Asians (28%); the maximum incidence (49%) was observed in an African population (3,23). Moreover, several types of research tried to clarify the connection between IG-F2BP2 rs4402960 variants and diabetes.…”

Evaluation of clients and care providers Satisfaction from provided services of Movable clinics, Rural Sohag; Sohag governorate-Upper Egypt.

“…Insulin secretion, which is essential for glucose metabolism, is regulated by the IGF2BP2 gene. rs4402960 and rs1470-579 that we investigated are the most widely studied polymorphisms of this gene and yielded both solid and weak or no associations with T2DM (3,4).…”

The relationship between polymorphism of IGF2BP2 gene rs4402960 and risk of pan-cancer: a meta-analysis and a bioinformatics analysis

“…IGF2BP2 belongs to an RNA-binding protein that is a postqualitative regulator of messenger RNA (mRNA) localization, stability, and conversion control 9 . Current research shows that the IGF2BP2 gene is related to the occurrence and development of diabetes [10][11][12] . IGF2BP2 is a key gene in the m6A signaling pathway and has recently been shown to play a role in the occurrence and development of various cancers [13][14][15][16][17] .…”