Interactive Effect of Bisphenol A (BPA) Exposure with -22G/C Polymorphism in LOX Gene on the Risk of Osteosarcoma

Jia, Jie; Tian, Qing; Liu, Yong; Shao, Zengwu; Yang, Shuai

doi:10.7314/apjcp.2013.14.6.3805

Cited by 19 publications

(18 citation statements)

References 16 publications

(9 reference statements)

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“…The etiology of breast cancer is becoming clearer by investigating the molecular alterations in germ line and somatic cell genes, and the interaction of these genes with steroid hormones (MacMahon et al, 1973;Hulkaand Moorman, 2008). Moreover, bisphenol A (BPA) is an environmental estrogen and its exposure may interact with the -22 G/C polymorphism of the LOX gene, thereby increasing the risk of OS (Jia et al, 2013). Therefore, these evidences suggest that the response to hormone stimulus may play a vital role in metastatic OS, but the mechanism needs to further study.…”

Section: Discussionmentioning

confidence: 99%

Identification and Functional Analysis of Differentially Expressed Genes Related to Metastatic Osteosarcoma

Niu

Zhao²,

Xu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Identification and Functional Analysis of Differentially Expressed Genes Related to Metastatic Osteosarcoma

Niu

Zhao²,

Xu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Various combination chemotherapy regimens as first-line treatment showed median response rates of 30-50%, and a median pro¬gression-free survival of 5-6 months (Jia et al, 2013;Jiang et al, 2013;Yang et al, 2013;Seker et al, 2014). In the passed several years, several clinical studies had been conducted to evaluate the efficacy of the ifosfamide containing regimens for patients with recurrent or refractory osteosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Ifosfamide-containing Regimens for Treating Patients with Osteosarcomas

Jiang²,

Dong³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: This systemic analysis was conducted to evaluate the efficacy and safety of an ifosfamidecontaining regimen in treating patients with osteosarcoma. Methods: Clinical studies evaluating the efficacy and safety of Ifosfamide-containing regimen on response and safety for patients with osteosarcoma were identified by using a predefined search strategy. Pooled response rate (RR) of treatment were calculated. Results: When ifosfamide-containing regimens were evaluated, 4 clinical studies which including 134 patients with osteosarcoma were considered eligible for inclusion. Systemic analysis suggested that, in all patients, pooled RR was 44.8% (60/134) in ifosfamide-containing regimens. Major adverse effects were neutropenia, leukopenia, and fatigue inIfosfamide-containing regimens; No treatment related death occurred in cantharidin combined regimens. Conclusion: This systemic analysis suggests that ifosfamide-containing regimens are associated with good response rate and acceptable toxicity in treating patients with osteosarcoma, but this result should be confirmed by randomized clinical trials.

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“…Osteosarcoma (OS) is the most common primary malignant bone tumor, occurring frequently in adolescents and possessing a high malignant severity (1)(2)(3)(4). OS is commonly identified on the distal femur and proximal tibia, possessing high rates of recurrence and metastasis, and a poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-26a induces osteosarcoma cell growth and metastasis via the Wnt/β-catenin pathway

Yuan

et al. 2015

Oncology Letters

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Abstract. MicroRNAs (miRNAs/miRs) are a type of highly conserved, small non-coding RNA that are vital to the post-transcriptional regulation of gene expression via base pairing with target mRNA 3'-untranslated regions (3'-UTRs). Several studies have indicated that the abnormal expression of miRNAs occurs frequently in human osteosarcoma (OS). In the present study, the role of miR-26a in the progression and metastasis of OS was investigated using reverse transcription-quantitative polymerase chain reaction, a luciferase activity assay, cell viability assay, in vitro migration and invasion assays, transfection and western blot analysis. miR-26a was upregulated in OS tissues and cell lines, and the expression of miR-26a was indicated to affect the proliferation, migration and invasion of OS Saos-2 cells. At the molecular level, the results showed that glycogen synthase kinase-3β (GSK-3β) was identified as a target of miR-26a, and the ectopic expression of miR-26a inhibited GSK-3β by directly binding to the 3'-UTR. Therefore, the expression of miR-26a was negatively correlated with GSK-3β in the OS tissues. These data suggest that miR-26a is significant in the proliferation of human OS cells due to the direct regulation of Wnt/β-catenin signaling. IntroductionOsteosarcoma (OS) is the most common primary malignant bone tumor, occurring frequently in adolescents and possessing a high malignant severity (1-4). OS is commonly identified on the distal femur and proximal tibia, possessing high rates of recurrence and metastasis, and a poor prognosis. Previously, surgical resection therapy resulted in a poor prognosis for OS patients (2). At present, the molecular pathogenesis and etiology of OS remain unclear. Therefore, the identification of the effector molecules or signaling pathways responsible for regulating tumor growth and metastasis is critical for improving OS treatment.MicroRNAs (miRNAs/miRs) are a type of highly conserved, small non-coding RNA that are vital to the post-transcriptional regulation of gene expression via base pairing with target mRNA 3'-untranslated regions (3'-UTRs) (5,6). Previous studies have indicated that the abnormal expression of miRNAs is closely associated with cell proliferation, apoptosis, metastasis and invasion in human cancers, including OS (7,8). miRNAs function as either tumor suppressors or oncogenes, depending on the role of the target genes. Previous studies have indicated that the inhibition of miR-26a may induce increased apoptosis in primary cultured chronic lymphocytic leukemia cells through suppression of phosphatase and tensin homolog (9). In addition, miR-26a inhibits hepatitis B virus transcription and replication by targeting the host factor cysteine and histidine-rich domain-containing, zinc-binding protein 1 (10).In the present study, the miRNA expression profiles of human OS samples and cell lines were compared with those of adjacent normal skeletal muscle and normal cell lines. miR-26a was indicated to be upregulated in human OS and cell lines, and the expression o...

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Interactive Effect of Bisphenol A (BPA) Exposure with -22G/C Polymorphism in LOX Gene on the Risk of Osteosarcoma

Cited by 19 publications

References 16 publications

Identification and Functional Analysis of Differentially Expressed Genes Related to Metastatic Osteosarcoma

Identification and Functional Analysis of Differentially Expressed Genes Related to Metastatic Osteosarcoma

Ifosfamide-containing Regimens for Treating Patients with Osteosarcomas

MicroRNA-26a induces osteosarcoma cell growth and metastasis via the Wnt/β-catenin pathway

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