Interactive associations of sex and hyperlipidemia with calcific tendinitis of the shoulder in Taiwanese adults

Cai, Lin; Nfor, Oswald Ndi; Su, Chun-Lang; Hsu, Shu‐Yi; Tantoh, Disline Manli; Liaw, Yung‐Po

doi:10.1097/md.0000000000023299

Cited by 6 publications

(8 citation statements)

References 28 publications

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“…Hyperlipidemia, a systemic metabolic disorder, has adverse effects on the cardiovascular and musculoskeletal systems. The mechanical properties of tendons are reduced by excessive accumulation of lipids in the extracellular matrix, and fatty infiltration can impair post-surgical tendon-bone healing and clinical outcomes [ 3 ]. A significantly higher incidence of calcific tendinitis was reported after 11 years of follow-up in patients with hyperlipidemia by Lin et al Meanwhile, treatment of hyperlipidemia served as an effective protective factor against RCCT [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Risk Factor Analysis for Predicting the Onset of Rotator Cuff Calcific Tendinitis Based on Artificial Intelligence

Dong

Zhao

et al. 2022

Computational Intelligence and Neuroscience

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Background. Symptomatic rotator cuff calcific tendinitis (RCCT) is a common shoulder disorder, and approaches combined with artificial intelligence greatly facilitate the development of clinical practice. Current scarce knowledge of the onset suggests that clinicians may need to explore this disease thoroughly. Methods. Clinical data were retrospectively collected from subjects diagnosed with RCCT at our institution within the period 2008 to 2020. A standardized questionnaire related to shoulder symptoms was completed in all cases, and standardized radiographs of both shoulders were extracted using a human-computer interactive electronic medical system (EMS) to clarify the clinical diagnosis of symptomatic RCCT. Based on the exclusion of asymptomatic subjects, risk factors in the baseline characteristics significantly associated with the onset of symptomatic RCCT were assessed via stepwise logistic regression analysis. Results. Of the 1,967 consecutive subjects referred to our academic institution for shoulder discomfort, 237 were diagnosed with symptomatic RCCT (12.05%). The proportion of women and the prevalence of clinical comorbidities were significantly higher in the RCCT cohort than those in the non-RCCT cohort. Stepwise logistic regression analysis confirmed that female gender, hyperlipidemia, diabetes mellitus, and hypothyroidism were independent risk factors for the entire cohort. Stratified by gender, the study found a partial overlap of risk factors contributing to morbidity in men and women. Diagnosis of hyperlipidemia, diabetes mellitus, and hypothyroidism in male cases and diabetes mellitus in female cases were significantly associated with symptomatic RCCT. Conclusion. Independent predictors of symptomatic RCCT are female, hyperlipidemia, diabetes mellitus, and hypothyroidism. Men diagnosed with hyperlipidemia, diabetes mellitus, and hypothyroidism are at high risk for symptomatic RCCT, while more medical attention is required for women with diabetes mellitus. Artificial intelligence offers pioneering innovations in the diagnosis and treatment of musculoskeletal disorders, and careful assessment through individualized risk stratification can help predict onset and targeted early stage treatment.

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Section: Discussionmentioning

confidence: 99%

Risk Factor Analysis for Predicting the Onset of Rotator Cuff Calcific Tendinitis Based on Artificial Intelligence

Dong

Zhao

et al. 2022

Computational Intelligence and Neuroscience

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“…According to the current literature, it is known that CT is frequently seen between the ages of 30 and 50. 2,15 In our study, the mean age of patients diagnosed with CT was found to be 57.40 ± 11.27 years. This may be due to the fact that we included patients with a diagnosis of CT who had a lipid profile at the time of admission and that young patients generally do not have a regular lipid profile, and middle-aged or elderly patients regularly have their lipid profile checked.…”

Section: Discussionmentioning

confidence: 51%

Hyperlipidemia in Patients with Calcific Tendinitis

et al. 2022

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Objective: Calcific tendinitis is a disease of unclear etiology and is associated with metabolic diseases. Hyperlipidemia, one of the metabolic diseases with systemic effects, may be associated with tendinopathy and tendinitis. In this study, we aimed to evaluate the relationship between hyperlipidemia and hyper trigl yceri demia , calcific tendinitis, the location of tendinitis, and the frequency of severely symptomatic tendinitis attacks. Methods: This retrospective study included a total of 2055 patients diagnosed with calcific tendinitis between August 1, 2019, and August 1, 2021. The patients were evaluated in terms of their hyperlipidemia and hypertriglyceridemia status, statin and/or fibrate use, and the frequency of tendinitis, and the location of attack. Results: It was observed that 64.4% (n = 230) of the patients had hyperlipidemia and 11.8% (n = 42) had hyper trigl yceri demia . It was determined that the most common tendinitis area among 357 patients was the shoulder. There was no statistically significant difference between the frequency of attacks (P = .712), and the location of attack (P = .069) in patients with hyperlipidemia. There was no statistically significant difference between the frequency of attacks (P = .735) and the location of attack (P = .286) in patients with hyper trigl yceri demia . However, a statistically significant difference was found between the attack area (P = .032) in patients with triglyceride values higher than the target recommended values. Conclusion:The frequency of hyperlipidemia is high in patients with calcific tendinitis; it will be useful to evaluate patients with calcific tendinitis in terms of hyperlipidemia.

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“…However, no published study has discussed the association between these comorbidities and calcific tendinopathy, except for one nationwide population-based matched cohort study, which found that hyperlipidaemia increases the risk of calcific tendinopathy of the shoulder, compared with non-hyperlipidaemia. 15 Abboud et al 29 also discovered that 63% patients with rotator cuff tear have higher triglyceride, cholesterol, and low-density lipoprotein cholesterol levels, as opposed to only 28% in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…14 A nationwide population-based matched cohort study published in 2020 has evaluated the correlation between hyperlipidaemia and calcific tendinitis/tendinopathy utilising the same enrolled diagnostic criteria of calcific tendinitis/tendinopathy from the NHIRD database. 15 Therefore, the accuracy of diagnosis in tendinitis/tendinopathy is adequate in the NHIRD database.…”

Section: Studydesignmentioning

confidence: 99%

“…Hyperlipidaemia, one of the risk factors of atherosclerosis, has been shown to increase the risk of calcific tendinitis of the shoulder in women. 15 MI, ischemic stroke, and CAD, which mainly results from atherosclerosis, may also increase the risk of soft tissue calcifications. 16 COPD causes hypoxemia and decreases oxygen supply to the peripheral tissues, which causes tissue hypoxia and may further lead to calcific depositions.…”

Section: Confoundingfactorconsiderationsmentioning

confidence: 99%

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Increased risk of shoulder calcific tendinopathy in diabetes mellitus: A nationwide, population‐based, matched cohort study

Chung

Ke³

et al. 2021

Int J Clin Pract

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Background: Calcific tendinopathy of the rotator cuff is a common cause of painful disability in the shoulder with unclear aetiology. Diabetes mellitus (DM) is associated with calcific tendinopathy; however, large epidemiological data are lacking. Thus, we conducted a nationwide population-based matched cohort study to investigate the risk for calcific tendinopathy of the shoulder in diabetic patients. Methods: The National Health Insurance Research Database of Taiwan was used to include 42 915 patients newly diagnosed with DM between 1 January 2000 and 31 December 2015 and randomly extract the data of 171 660 individuals, as a matched control group. All individuals were followed-up until the development of calcific tendinopathy or the end of 2015. Results: Overall, 122 patients from the DM group (0.284%) developed calcific tendinopathy compared with 340 individuals from the non-DM group (0.198%). TheKaplan-Meier analysis indicated that patients with DM had a higher risk of calcific tendinopathy since the eighth year of follow-up (log-rank test, P = .006). Cox proportional hazard regression revealed that the adjusted hazard ratio of calcific tendinopathy in diabetic patients to that in non-diabetic patients was 1.276 (95% confidence interval 1.037-1.571, P = .002). Moreover, the stratified analysis disclosed that DM was a strong independent risk factor for calcific tendinopathy irrespective of the existing comorbidities. Conclusions:This study demonstrated that patients with DM had a 27% increased risk of developing calcific tendinopathy of the shoulder, 8 years after initially being diagnosed with DM.

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Interactive associations of sex and hyperlipidemia with calcific tendinitis of the shoulder in Taiwanese adults

Cited by 6 publications

References 28 publications

Risk Factor Analysis for Predicting the Onset of Rotator Cuff Calcific Tendinitis Based on Artificial Intelligence

Risk Factor Analysis for Predicting the Onset of Rotator Cuff Calcific Tendinitis Based on Artificial Intelligence

Hyperlipidemia in Patients with Calcific Tendinitis

Increased risk of shoulder calcific tendinopathy in diabetes mellitus: A nationwide, population‐based, matched cohort study

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