Interactive antifungal activity of the glycoalkaloids α-solanine and α-chaconine

In vivoantimalarial activities of glycoalkaloids isolated from Solanaceae plants

“…The results indicated that the glycoalkaloids with chacotriose exhibited greater suppression than the glycoalkaloids with solatriose against Plasmodium yoelii in mice. Our results were similar to those previously reported for the glycoalkaloids chaconine and solanine in disrupting cell membranes (Keukens et al, 1995(Keukens et al, , 1996, antifungal activity (Fewell & Roddick, 1993), blocking of sodium ion active transport in frog skin (Blankemeyer et al, 1995), antitumorigenic activity (Lee et al, 2004;Friedman et al, 2005) and Xenopus embryo teratogenesis (Friedman et al, 1992;Rayburn et al, 1994). As mentioned above, the correlation of solamargine and solasonine in antimalarial activities was similar to that in antifungal activity (Cipollini & Levey, 1997), developmental toxicology in frog embryos (Blankemeyer et al, 1998) and antiproliferative activities against human colon and liver cancer cell lines (Lee et al, 2004).…”

“…Several studies have suggested that the paired glycoalkaloids might act synergistically in plant defense. Positive synergistic effects have been observed for chaconine and solanine in permeation of liposomes (Roddick & Rijnenberg, 1986), disrupting membranes (Keukens et al, 1995), antifungal (Fewell & Roddick, 1993) and antitumorigenic effects (Friedman et al, 2005). However, combinations of chaconine and solanine were slightly antagonistic or non-interactive in acetylcholinesterase inhibition (Roddick, 1989).…”

“…Plants are thought to produce glycoalkaloids to protect themselves from attacks from microbes, insects and animals. Previous studies have shown that glycoalkaloids are biologically active as antifungals (Fewell & Roddick, 1993), antimicrobials (Wanyonyi et al, 2003), antivirals (Thorne et al, 1985), cancer chemotherapeutics (Kuo et al, 2000;Lee et al, 2004;Friedman et al, 2005), and embryotoxins (Friedman et al, 1991).…”

Processing, Valorization and Application of Bio-Waste Derived Compounds from Potato, Tomato, Olive and Cereals: A Review

“…Even if the tubers are a valuable source of nutritional elements, potatoes are also rich in steroidal alkaloids, a class of secondary metabolites commonly found in the plants of Solanaceae family. Steroidal alkaloids are associated with defense against bacterial [69], fungal [70] and insect attacks [71]. These compounds are toxic and their adverse effects on human health are typically associated with symptoms such as colic pain, diarrhea, gastroenteritis, vomiting, fever, low blood pressure, rapid pulse and neurological disorders [72,73].…”

Bioproducts from Potatoes. A Review

“…Glycoalkaloids can be found in all parts of potato plants and they can be used in pharmaceuticals, due their properties to serve as antibiotics, anti-allergens, antipyretics, anti-inflammatory and hyperglycaemic compounds at certain doses and use conditions. But these compounds have to be removed from potatoes for food production, as they can be toxic for humans, when exceeding an amount of 200 mg per kilogram of potatoes, however most of them are reduced during processing, like cooking [8], [34]- [36].…”