INTERACTIONS OF Δ<sup>9</sup>‐TETRAHYDROCANNABINOL WITH OTHER DRUGS

Hollister, Leo E.

doi:10.1111/j.1749-6632.1976.tb27932.x

Cited by 13 publications

(2 citation statements)

References 29 publications

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“…Central nervous system: Cannabis acts essentially as a central nervous system (CNS) depressant (3,39,40); therefore, its main acute effects in many ways resemble those of alcohol. It produces drowsiness and decreased alertness, being synergistic with alcohol, barbiturates and other CNS depressants in this respect (2,41,42). Similarly, although THC has minimal respiratory depressant effect by itself, it may be synergistic with other depressants.…”

Section: Pharmacological Effects Acute Effectsmentioning

confidence: 99%

Medicinal Use of Cannabis: History and Current Status

Kalant

2001

Pain Research and Management

146

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OBJECTIVE:To provide an overview of the history and pharmacology of cannabis in relation to current scientific knowledge concerning actual and potential therapeutic uses of cannabis preparations and pure cannabinoids. METHODS:The literature on therapeutic uses of cannabis and cannabinoids was assessed with respect to type of study design, quality and variability of data, independent replications by the same or other investigators, magnitude of effects, comparison with other available treatments and reported adverse effects. The results of this review were also compared with those of major international reviews of this topic in the past five years. CONCLUSIONS: Pure tetrahydrocannabinol and several analogues have shown significant therapeutic benefits in the relief of nausea and vomiting, and stimulation of appetite in patients with wasting syndrome. Recent evidence clearly demonstrates analgesic and antispasticity effects that will probably prove to be clinically useful. Reduction of intraocular pressure in glaucoma and bronchodilation in asthma are not sufficiently strong, long lasting or reliable to provide a valid basis for therapeutic use. The anticonvulsant effect of cannabidiol is sufficiently promising to warrant further properly designed clinical trials. There is still a major lack of long term pharmacokinetic data and information on drug interactions. For all the present and probable future uses, pure cannabinoids, administered orally, rectally or parenterally, have been shown to be effective, and they are free of the risks of chronic inflammatory disease of the airways and upper repiratory cancer that are associated with the smoking of crude cannabis. Smoking might be justified on compassionate grounds in terminally ill patients who are already accustomed to using cannabis in this manner. Future research will probably yield new synthetic analogues with better separation of therapeutic effects from undesired psychoactivity and other side effects, and with solubility properties that may permit topical administration in the eye, or aerosol inhalation for rapid systemic effect without the risks associated with smoke inhalation.

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Section: Pharmacological Effects Acute Effectsmentioning

confidence: 99%

Medicinal Use of Cannabis: History and Current Status

Kalant

2001

Pain Research and Management

146

View full text Add to dashboard Cite

show abstract

“…It is generally acknowledged that the combined effects of alcohol and marijuana are "additive" in the sense that performance impairments induced by the combined administration of both drugs are greater than those observed with either drug alone (Burford et al 1975;Franks et al 1975;Smiley et al 1975;Smith 1976). Subjective aspects of marijuana intoxication have also been reported to be enhanced by the concurrent use of alcohol (Hollister 1976;. However, alcohol consumption decreased even in subjects who smoked only 1 to 3 marijuana cigarettes per day (cf.…”

Section: Alcohol and Marijuana Use In Menmentioning

confidence: 99%