Interactions of Volatile Anesthetics with Epinephrine, ß-Receptor Antagonists and Calcium Channel Blockers

Prys‐Roberts, C.

doi:10.1007/978-3-642-71232-6_12

Cited by 1 publication

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“…This is probably related to the different effect induced in-vivo by the two anaesthetics on atrioventricular conduction. Halothane slows conduction through the A-V node and subsidiary pacemakers respond to increased adrenergic activity, or to exogenously administered catecholamines, by establishing either ventricular extrasystoles or tachycardia (Prys-Roberts 1987). Isoflurane, however, has the opposite effect on atrioventricular conduction (Marshall & Wollman 1985) and this could protect against arrhythmogenesis.…”

Section: Discussionmentioning

confidence: 99%

Halothane, Isoflurane and Enflurane Potentiate the Effect of Noradrenaline on Ventricular Automaticity in the Rat Heart: Evidence of the Involvement of Both α- and β-Adrenoceptors

Cárceles

Laorden

Hernández

et al. 1990

Journal of Pharmacy and Pharmacology

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Direct evidence has been sought as to what extent the sensitization of heart to the arrhythmogenic action of sympathomimetic drugs in the presence of the inhalatory anaesthetics, halothane, isoflurane and enflurane, is mediated by either alpha- or beta-adrenoceptors. For this purpose, the effects of isoprenaline, noradrenaline and phenylephrine on ventricular automaticity induced by local injury have been studied in the isolated right ventricle of the rat. Isoprenaline was more potent in increasing ventricular automaticity than either phenylephrine or noradrenaline. The anaesthetic potentiated the effects of noradrenaline, as well as that of higher concentrations of phenylephrine, but not those of isoprenaline. These results support the contention that increases in ventricular automaticity induced by sympathomimetic drugs are mainly mediated by adrenoceptors of the beta-type. However, the simultaneous activation of both alpha- and beta-adrenoceptors seems to be necessary for the effect of the anaesthetics in sensitizing the heart to sympathomimetic drugs.

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Section: Discussionmentioning

confidence: 99%