Interactions of visual hallucinations, rapid eye movement sleep behavior disorder and cognitive impairment in Parkinson's disease: A review

Lenka, Abhishek; Hegde, Shantala; Jhunjhunwala, Ketan; Pal, Pramod Kumar

doi:10.1016/j.parkreldis.2015.11.018

Cited by 55 publications

(31 citation statements)

References 84 publications

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“…Such side effects could potentially be reduced by sparing neural circuits from high-frequency stimulation when dysfunction is limited or by patterning stimulation so that it is far more selective for dysfunctional neural dynamics. In line with this, recent studies suggest that DBS might be more efficient and efficacious if modulated in response to the inferred state of activity in pathological brain circuits 17,18…”

mentioning

confidence: 75%

“…However, this may be suboptimal. For example, beta power in the STN correlates with bradykinesia and rigidity, but it does not do so with tremor 18,23. Thus aDBS systems that rely on beta activity feedback run the risk of not controlling tremor.…”

Section: Limitations and Roadblocksmentioning

confidence: 99%

“…3). Indeed, there are many other possible brain and peripheral signals that correlate with motor impairment that could, in principle, be combined for more precise control of different symptoms 18,61–63…”

Section: Limitations and Roadblocksmentioning

confidence: 99%

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Adaptive Deep Brain Stimulation for Movement Disorders: The Long Road to Clinical Therapy

et al. 2017

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Continuous high-frequency DBS is an established treatment for essential tremor and Parkinson’s disease. Current developments focus on trying to widen the therapeutic window of DBS. Adaptive DBS (aDBS), where stimulation is dynamically controlled by feedback from biomarkers of pathological brain circuit activity, is one such development. Relevant biomarkers may be central, such as local field potential activity, or peripheral, such as inertial tremor data. Moreover, stimulation may be directed by the amplitude or the phase (timing) of the biomarker signal. In this review, we evaluate existing aDBS studies as proof-of-principle, discuss their limitations, most of which stem from their acute nature, and propose what is needed to take aDBS into a chronic setting.

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mentioning

confidence: 75%

Section: Limitations and Roadblocksmentioning

confidence: 99%

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Adaptive Deep Brain Stimulation for Movement Disorders: The Long Road to Clinical Therapy

et al. 2017

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“…24 Furthermore, other risk factors for PD psychosis have been identified whose role is unclear, including rapid eye movement (REM) sleep behaviour disorder (see ref. 25 for a review), depression 26 and dopamine agonist medication. 9 13 Such findings raise the possibility that the earliest symptoms of PD psychosis may differ in their aetiological cause to later symptoms.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for early psychosis in PD: insights from the Parkinson's Progression Markers Initiative

ffytche

Pereira

Ballard

et al. 2017

J Neurol Neurosurg Psychiatry

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Parkinson's Disease (PD) psychosis refers to the spectrum of illusions, formed hallucinations and delusions that occur in PD. Visual hallucinations and illusions are thought to be caused by specific cognitive and higher visual function deficits and patients who develop such symptoms early in the disease course have greater rates of cognitive decline and progression to dementia. To date, no studies have investigated whether such deficits are found prior to the onset of PD psychosis. Here we compare baseline cognitive, biomarker (structural imaging and cerebrospinal fluid) and other PD psychosis risk factor data in patients who go on to develop illusions or hallucinations within 3-4 years of follow-up in the Parkinson's Progression Markers Initiative cohort of newly diagnosed PD. Of n=423 patients with PD, n=115 (27%) reported predominantly illusions with median onset at 19.5 months follow-up. At study entry these patients had reduced CSF amyloid Aß1-42, lower olfaction scores, higher depression scores and increased REM sleep behaviour disorder symptoms compared to patients without early onset PD psychosis but no differences in cognitive, higher visual or structural imaging measures. A subset of patients with early onset formed hallucinations (n=21) had reduced higher visual function at baseline, cortical thinning in parietal, occipital and frontal cortex and reduced hippocampal volume. The findings suggest early onset illusions and formed hallucinations are linked to amyloid pathology in PD and point to a difference in the underlying pathophysiological mechanism of illusions and formed hallucinations, with implications for their respective links to future cognitive decline.

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“…Imaging, physiological and neuropsychological studies have suggested common neurobiological processes leading to RBD, hallucinations and cognitive impairment. PD patients with the presence of RBD or psychosis will possibly progress to dementia [60]. As mentioned earlier, neuropsychological traits such as anxiety or executive functioning or verbal f luency impairment have been also associated with development of psychosis.…”

Section: Should Clinicians Be Doing More To Address Pdp?mentioning

confidence: 93%

Parkinson’s Disease Psychosis: Therapy Tips and the Importance of Communication Between Neurologists and Psychiatrists

Martínez-Ramírez

Okun

Jaffee

2016

Neurodegener. Dis. Manag.

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Parkinson's disease (PD) is a chronic and complex neurodegenerative disorder resulting in a mixture of motor and nonmotor symptoms. Psychosis develops in around 60% of PD patients during and can be one of the most challenging nonmotor symptoms. PD psychosis is considered the single greatest precipitant for nursing home placement. PD psychosis is an independent predictor of increased mortality, and there is no 'ideal' or universal treatment strategy. The treatment approach to PD psychosis should be tailored and individualized for each patient. In this review, we will discuss PD psychosis and provide practical treatment considerations for neurologists, psychiatrists and other healthcare professionals. We stress the importance of real-time communication between members of the healthcare team.

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Interactions of visual hallucinations, rapid eye movement sleep behavior disorder and cognitive impairment in Parkinson's disease: A review

Cited by 55 publications

References 84 publications

Adaptive Deep Brain Stimulation for Movement Disorders: The Long Road to Clinical Therapy

Adaptive Deep Brain Stimulation for Movement Disorders: The Long Road to Clinical Therapy

Risk factors for early psychosis in PD: insights from the Parkinson's Progression Markers Initiative

Parkinson’s Disease Psychosis: Therapy Tips and the Importance of Communication Between Neurologists and Psychiatrists

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