Interactions of Thiamin, Riboflavin, and Other B‐vitamins

Sauberlich, Howerde E.

doi:10.1111/j.1749-6632.1980.tb21329.x

Cited by 15 publications

(7 citation statements)

References 48 publications

(5 reference statements)

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“…The gene-specific maps highlighted in this paper have strong interactions with nutrients known to be essential for the OCM pathway (Hall and Finkler 1965;Leclerc et al 1998;Sauberlich 1980). Because these genes are integral parts of OCM, alterations in genetic information are thought to affect utilization of nutrients such as cobalamin, Fig.…”

Section: Discussionmentioning

confidence: 95%

Concept mapping One-Carbon Metabolism to model future ontologies for nutrient–gene–phenotype interactions

et al. 2014

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Advances in the development of bioinformatic tools continue to improve investigators' ability to interrogate, organize, and derive knowledge from large amounts of heterogeneous information. These tools often require advanced technical skills not possessed by life scientists. User-friendly, low-barrier-to-entry methods of visualizing nutrigenomics information are yet to be developed. We utilized concept mapping software from the Institute for Human and Machine Cognition to create a conceptual model of diet and health-related data that provides a foundation for future nutrigenomics ontologies describing published nutrient-gene/polymorphism-phenotype data. In this model, maps containing phenotype, nutrient, gene product, and genetic polymorphism interactions are visualized as triples of two concepts linked together by a linking phrase. These triples, or ''knowledge propositions,'' contextualize aggregated data and information into easy-to-read knowledge maps. Maps of these triples enable visualization of genes spanning the One-Carbon Metabolism (OCM) pathway, their sequence variants, and multiple literature-mined associations including concepts relevant to nutrition, phenotypes, and health. The concept map development process documents the incongruity of information derived from pathway databases versus literature resources. This conceptual model highlights the importance of incorporating information about genes in upstream pathways that provide substrates, as well as downstream pathways that utilize products of the pathway under investigation, in this case OCM. Other genes and their polymorphisms, such as TCN2 and FUT2, although not directly involved in OCM, potentially alter OCM pathway functionality. These upstream gene products regulate substrates such as B12. Constellations of polymorphisms affecting the functionality of genes along OCM, together with substrate and cofactor availability, may impact resultant phenotypes. These conceptual maps provide a foundational framework for development of nutrient-gene/polymorphism-phenotype ontologies and systems visualization.

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Section: Discussionmentioning

confidence: 95%

Concept mapping One-Carbon Metabolism to model future ontologies for nutrient–gene–phenotype interactions

et al. 2014

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“…Interactions between the B vitamins themselves (Sauberlich, 1980;Chanarin et aJ., 1985) and drugs (Pinto et a1.,1981) further complicate the matter. Factors contributing to malnutrition in the elderly, other than poor intake, include age-related changes in absorption, tissue uptake, utilization and requirements.…”

Section: Discussionmentioning

confidence: 99%

“…Factors contributing to malnutrition in the elderly, other than poor intake, include age-related changes in absorption, tissue uptake, utilization and requirements. Interactions between the B vitamins themselves (Sauberlich, 1980;Chanarin et aJ., 1985) and drugs (Pinto et a1.,1981) further complicate the matter. Though it is often assumed that nutrient requirements fall with advancing age, it is possible that diminished metabolic efficiency may demand a higher requirement.…”

Section: Discussionmentioning

confidence: 99%

The B vitamin content of hospital meals and potential low intake by elderly inpatients

Thomas¹,

Finglas²,

Bunker³

1988

J Human Nutrition Diet

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The content of thiamin, riboflavin, vitamin B6 (pyridoxamine, pyridoxal, pyridoxine), niacin and total folate were determined in the meal choices comprising a typical day's menu in a teaching hospital. Thiamine, riboflavine, and B6 were measured by HPLC analysis, folate by microbiological assay, and niacin content was calculated from food tables. The results were compared with UK Recommended Daily Amounts (RDA) whenever possible (thiamine, riboflavine and niacin). Vitamin B6 and folate results were compared with the US Recommended Daily Dietary Amount (RDDA) as no British recommendation was available. Elderly inpatients selected meals which, even if completely consumed, provided half the current recommendation for vitamin B6 and one‐third of the recommendation for folate. More than half the meal selections provided less than recommended amounts of riboflavine, and in a quarter of cases less than the recommended amount of thiamine.

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“…Flavin mononucleotide (FMN) is a necessary cofactor for pyridoxine phosphate oxidase that converts pyridoxine 5’‐phosphate and pyridoxamine 5’‐phosphate to the active form of pyridoxal 5’‐phosphate. (Adapted from Sauberlich, ).…”

Section: Riboflavin (Vitamin B2)mentioning

confidence: 99%

“…Pellagra commonly occurs in populations on monotonous maize-based diets because the niacin in maize is bound within (FMN) is a necessary cofactor for pyridoxine phosphate oxidase that converts pyridoxine 5'-phosphate and pyridoxamine 5'-phosphate to the active form of pyridoxal 5'-phosphate. (Adapted from Sauberlich, 1980). hemicellulose in a heat-stable, nonbioavailable form (Wall & Carpenter, 1998).…”

Section: Niacin (Vitamin B 3 )mentioning

confidence: 99%

Global Concerns with B Vitamin Statuses: Biofortification, Fortification, Hidden Hunger, Interactions, and Toxicity

Titcomb

Tanumihardjo

2019

Comp Rev Food Sci Food Safe

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The prevalence of undernutrition due to insufficient energy intake has been reduced by nearly 50% since 1990. This reduction is largely attributed to improved yields of staple crops, such as wheat, rice, and maize; however, these improvements did little for micronutrient deficiencies that affect an estimated two billion people worldwide. Starchy staple crops are energy dense but are often lacking in one or more B vitamins, making resource‐constrained people who consume monotonous diets comprised predominantly of these staples at risk for developing deficiency. B vitamin deficiencies occur due to a poor overall nondiversified diet and rarely occur alone. Many B vitamins are essential cofactors involved in the metabolism of other nutrients, including other B vitamins, whereby the deficiency of one B vitamin affects the metabolism and status measurements of another. Food fortification efforts have nearly eradicated diseases of extreme B vitamin deficiency, such as beriberi from thiamin deficiency and pellagra from niacin deficiency. However, subclinical deficiency, sometimes referred to as hidden hunger, is still common especially in low‐income countries. Most dietary B vitamins, due to their water‐soluble nature, are not a concern for excessive intakes, but synthetic forms used for fortification and supplements sometimes can have adverse effects when consumed in high amounts. Biofortified crops offer a long‐term sustainable method to increase the amount of dietary B vitamins for people who rely on staple crops for most of their caloric intake. Efforts have been made to improve B vitamin content of crops, especially for thiamin, vitamin B6, and folate, but none have undergone human feeding trials; therefore, more research is needed to provide sustainable and scalable solutions in many parts of the world.

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Interactions of Thiamin, Riboflavin, and Other B‐vitamins

Cited by 15 publications

References 48 publications

Concept mapping One-Carbon Metabolism to model future ontologies for nutrient–gene–phenotype interactions

Concept mapping One-Carbon Metabolism to model future ontologies for nutrient–gene–phenotype interactions

The B vitamin content of hospital meals and potential low intake by elderly inpatients

Global Concerns with B Vitamin Statuses: Biofortification, Fortification, Hidden Hunger, Interactions, and Toxicity

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