Understanding the complex relationship between ESSD and human well-being is of paramount significance to protecting regional ecology, enhancing human well-being and achieving sustainable development. We take the Yangtze River Economic Belt as an example and use multi-source data to analyse land use and cover change, as well as the spatiotemporal evolution of ESSD and human well-being. We explore and reveal the coupling coordination relationship between ESSD and human well-being. The results show that from 2000 to 2020, the overall trend in ESs in the region improved significantly, and the supply notably increased, whereas the demand growth rate was even more pronounced. The supply–demand ratio for water yield and soil conservation showed little change, with variations of <10%. However, the supply–demand ratio for carbon sequestration declined significantly by 41.83%, whereas that for food supply increased notably by 42.93%. The overall spatial pattern in ESSD presented a mismatch, which was characterised by ‘low supply and high demand in the eastern region and high supply and low demand in the western region’. Overall, human well-being remained stable and was in line with the level of socio-economic development, thereby exhibiting a distinct trend of well-being ‘polarisation between the rich and poor’. Well-being was higher in the eastern and central urban agglomerations and lower in the western plateau and mountainous areas. Over 20 years, the degree of coupling coordination between ESSD and human well-being increased by 0.0107, and the coupling level gradually transitioned from moderate imbalance to moderate coordination. Spatially, Hubei Province, Chongqing Municipality and the Yangtze River Delta were the main ‘high–high’ agglomeration areas, whereas the Sichuan Basin and the Yunnan-Guizhou Plateau were the main ‘low–low’ agglomeration areas. Based on these findings, we propose the following management recommendations for the Yangtze River Economic Belt and other related great river economic belts: optimise land use structure, rationally allocate natural resources, strengthen regional and external connections and promote regional coordinated development, enhance the implementation of policies for ecological and environmental protection, establish regional ecological compensation mechanisms and coordinate ecological protection in a full scope and focus on harmonising human–land relationships, build a multi-stakeholder collaborative governance mechanism and promote regional ecological protection and the elevation of human well-being.
