Interactions of quinine with polyacrylic and poly-L-glutamic acids in aqueous solutions

Porcar, Iolanda; Codoñer, Armando; Gómez, Clara M.; Abad, Concepción; Campos, Agustı́n

doi:10.1016/j.eurpolymj.2003.11.011

Cited by 8 publications

(6 citation statements)

References 33 publications

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“…The polypeptide, PGA, was chosen for comparative reasons due to its similarity with BSA, i.e. PGA (pK a , 4.07-4.25 26 ) is net negatively charged to BSA at pH 7 and glutamic acid is one of the most abundant amino acid in the amino acid sequence of BSA.…”

Section: Chemicals Solutions and Substrates Preparationmentioning

confidence: 99%

Adsorption of bovine serum albumin on silver surfaces enhances the release of silver at pH neutral conditions

Wang

Herting

Wallinder

et al. 2015

Phys. Chem. Chem. Phys.

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Metallic biomaterials are widely used to replace and/or restore the function of damaged bodily parts. The use of silver as antibacterial coatings onto implants has recently gained large interest in medical applications. The extent of silver that can be released into different biological fluids from such coatings is, except for the surface characteristics of the coating, governed by parameters such as protein characteristics, adsorbed layer properties, formation of silver-protein complexes as well as concentrations of proteins in the solution. This study aims to relate the structure of adsorbed net negatively charged bovine serum albumin (BSA), which is the most abundant protein in serum, to the release of silver from metallic silver surfaces in order to elucidate if the net charge of the protein has any effect of the silver release. Simultaneous adsorption measurements were performed in real time on the very same surface using combined ellipsometry and quartz crystal microbalance with dissipation monitoring (QCM-D) measurements to provide a more comprehensive understanding on adsorption kinetics and layer structures. The amount of released silver into solution was measured by means of graphite furnace atomic absorption spectroscopy (GF-AAS). The structure of the adsorbed BSA layer largely influenced the amount of released silver, an enhancement that increased with BSA concentration. These observations are in complete contrast to the effect of net positively charged lysozyme (LSZ) adsorbed on silver, previously studied by the authors, for which a complete surface coverage suppressed the possibility for silver release. The underlying mechanisms behind the enhanced release of silver in the presence of BSA were mainly attributed to surface complexation between BSA and silver followed by an enhanced exchange rate of these surface complexes with BSA molecules in the solution, which in turn increase the amount of released silver in solution.

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Section: Chemicals Solutions and Substrates Preparationmentioning

confidence: 99%

Adsorption of bovine serum albumin on silver surfaces enhances the release of silver at pH neutral conditions

Wang

Herting

Wallinder

et al. 2015

Phys. Chem. Chem. Phys.

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“…[16][17][18] Poly-Glutamic acid (Poly-Glu) is one such biopolymer with various biological functions and promising properties for basic and applied research. [19][20][21][22][23][24][25][26] Poly-Glu is known to promote electron transfer and also provide conducting bridges. [27][28][29] It consists of various units of Glutamic acid connected through γ -peptide linkages and the α-carboxyl groups are free to bind with a wide range of compounds.…”

Section: Introductionmentioning

confidence: 99%

Determination of gallic acid using poly(glutamic acid): graphene modified electrode

et al. 2019

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Gallic acid (GA) is one of the main phenolic components occurring naturally in plants and has been a subject of increasing interest owing to its antioxidant, anti-mutagenic and anti-carcinogenic properties. The present work describes a rapid and cost-effective analytical procedure for the determination of gallic acid. Poly-Glu/rGO electrode was fabricated by the electro-polymerisation of glutamic acid on reduced graphene oxide (rGO) modified paraffin impregnated graphite electrode (PIGE). The modified electrode was characterized by SEM, AFM and ATR-IR. The electrochemical behavior of gallic acid at the modified sensor was studied by voltammetric and amperometric techniques under optimized conditions in pH 5 acetate buffer. The electrode showed good linear response towards the determination of gallic acid over the range of 0.03-480 µM with 0.01 µM as the detection limit for voltammetric technique and the amperometric technique showed a linear range of 1-17 µM with 0.33 µM as the detection limit. The electrode also showed good stability and reproducibility with a sensitivity of 0.97 µM/µA. The proposed method can be applied to detect GA in real samples with satisfactory results.

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“…The general trend observed is that the degree of association increases as the molar ratio does, i.e., as the polymer concentration in the blend increases. Regardless of the system assayed, it should be expected39, 40 that α reached a nearly constant value, for medium and high R i values, given that α represents the degree of association and it cannot increase continuously. At this optimum R i value, the interaction should be highly effective, the steric hindrance minimized and the miscibility maximized.…”

Section: Resultsmentioning

confidence: 99%

Miscibility of Blends of Biodegradable Polymers and Copolymers with Different Plasticizers

Garcı́a-Lopera

Monzó

Porcar

et al. 2008

Macro Chemistry & Physics

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Miscibility between components of different plasticizer(A)/solvent(B)/biodegradable polymer(C) ternary systems with H‐bonding has been compared. Systems were formed by two H‐donor phenolic plasticizers, 4‐nonylphenol (NP) and 4:4′‐dihydroxydiphenylmethane (BPF); an H‐acceptor solvent, epichlorohydrin (ECH); and H‐acceptor poly(3‐hydroxybutyrate) (PHB) or poly[(3‐hydroxybutyrate)‐co‐(3‐hydroxyvalerate)] (PHBHV) copolymers. Blend miscibility is the result of the balance of three competitive H‐bondings: plasticizer self‐association (AA), plasticizer‐solvent (AB) and plasticizer‐polymer (AC) interassociations. The strength and extent of such specific interactions have been experimentally monitored by fluorescence spectroscopy either in solution or in solid state. Theoretical modelling has been conducted with a recent thermodynamic approach based on two free‐energy excess functions.

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Interactions of quinine with polyacrylic and poly-L-glutamic acids in aqueous solutions

Cited by 8 publications

References 33 publications

Adsorption of bovine serum albumin on silver surfaces enhances the release of silver at pH neutral conditions

Adsorption of bovine serum albumin on silver surfaces enhances the release of silver at pH neutral conditions

Determination of gallic acid using poly(glutamic acid): graphene modified electrode

Miscibility of Blends of Biodegradable Polymers and Copolymers with Different Plasticizers

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