Interactions of poly (vinyl alcohol) and poly (N-isopropylacrylamide) with tannic acid and pyrazole derivatives: The identification of H-bonds for revealing a “Two-Molecules” carrier system

Ok, Salim; Altun, Ahmet

doi:10.1016/j.eurpolymj.2018.09.028

Cited by 8 publications

(2 citation statements)

References 53 publications

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“…The hydrogen bond interactions between TA and PVA are mainly between the À OH of TA and À OH moiety of PVA as shown in figure 5. [36,37]…”

Section: Tannic Acid Releasementioning

confidence: 99%

In Vitro Release Kinetics of Nystatin and Tannic Acid in Artificial Body Fluids from Hydrogels Prepared by Using Polyvinylpyrrolidone Crosslinked with Tannic Acid

Patel,

Lata,

Sharma

et al. 2023

ChemistrySelect

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Biocompatible hydrogels of polyvinylpyrrolidone (PVP) with tannic acid (TA) in the weight ratios of 1 : 0.70 (70 %)–1 : 0.60 (60 %) were prepared and loaded with the antifungal drug, nystatin (NYS). The hydrogel is expected to exhibit a two‐fold (anti‐bacterial and anti‐fungal) characteristics. Infrared spectroscopy (IR), viscometry and differential scanning calorimetry (DSC) were used to investigate interactions between PVP and TA. In vitro release kinetics of NYS in simulated body fluid (SBF) and sweat (SS) were studied using ultra‐violet spectroscopy (UV) and high‐performance liquid chromatography (HPLC). An increase in the glass transition temperature (Tg) of PVP accompanied with changes observed in the OH stretching, C=O and the C−O−C regions in the IR spectrum in dried PVP/TA hydrogel suggested physical crosslinking. The swelling of the hydrogels in distilled deionized water (DDW), SBF and SS decreased with increasing TA concentration and showed pH sensitivity. TA release followed the Korsmeyer‐Peppas kinetic model regardless of swelling media while NYS followed the Korsmeyer‐Peppas and Hixson‐Crowell cube root law in SS and SBF respectively. TA was active against Escherichia coli and Staphylococcus aureus while NYS against Candida albicans. A topical patch was prepared by adhering the drug loaded PVP/TA hydrogel onto silicone strips.

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“…The hydrogen bond interactions between TA and PVA are mainly between the À OH of TA and À OH moiety of PVA as shown in figure 5. [36,37]…”

Section: Tannic Acid Releasementioning

confidence: 99%

In Vitro Release Kinetics of Nystatin and Tannic Acid in Artificial Body Fluids from Hydrogels Prepared by Using Polyvinylpyrrolidone Crosslinked with Tannic Acid

Patel,

Lata,

Sharma

et al. 2023

ChemistrySelect

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“…Therefore, its determination is the first essential step. Despite TA's industrial and technological relevance, few studies employ computational methodologies to understand its properties and interactions in different applied systems [20][21][22][23] . The detailed conformational analysis and structural optimization of large and flexible molecules, such as TA, consist of a computationally costly task since they span a large conformation space with several local minima.…”

Section: Introductionmentioning

confidence: 99%

Conformational analysis of tannic acid: environment effects in electronic and reactivity properties

Petry,

Focassio,

Schleder

et al. 2021

Preprint

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Polyphenols are natural molecules of crucial importance in many applications, of which tannic acid (TA) is one of the most abundant and established. Most high-value applications require precise control of TA interactions with the system of interest. However, the molecular structure of TA is still not comprehended at the atomic level, of which all electronic and reactivity properties depend. Here, we combine an enhanced sampling global optimization method with density functional theory (DFT)-based calculations to explore the conformational space of TA assisted by unsupervised machine learning visualization, and then investigate its lowest energy conformers. We study the external environment's effect on the TA structure and properties. We find that vacuum favors compact structures by stabilizing peripheral atoms' weak interactions, while in water, the molecule adopts more open conformations. The frontier molecular orbitals of the conformers with lowest harmonic vibrational free energy have a HOMO-LUMO energy gap of 2.21 (3.27) eV, increasing to 2.82 (3.88) eV in water, at the DFT generalized gradient approximation (and hybrid) level of theory. Structural differences also change the distribution of potential reactive sites. We establish the fundamental importance of accurate structural consideration in determining TA and related polyphenols interactions in relevant technological applications.

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Double cross-linked poly(vinyl alcohol) microcomposite hydrogels with high strength and cell compatibility

Pei

Peng

Wan

et al. 2021

European Polymer Journal

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Interactions of poly (vinyl alcohol) and poly (N-isopropylacrylamide) with tannic acid and pyrazole derivatives: The identification of H-bonds for revealing a “Two-Molecules” carrier system

Cited by 8 publications

References 53 publications

In Vitro Release Kinetics of Nystatin and Tannic Acid in Artificial Body Fluids from Hydrogels Prepared by Using Polyvinylpyrrolidone Crosslinked with Tannic Acid

In Vitro Release Kinetics of Nystatin and Tannic Acid in Artificial Body Fluids from Hydrogels Prepared by Using Polyvinylpyrrolidone Crosslinked with Tannic Acid

Conformational analysis of tannic acid: environment effects in electronic and reactivity properties

Double cross-linked poly(vinyl alcohol) microcomposite hydrogels with high strength and cell compatibility

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