Interactions of piperonyl butoxide and its analogue with CYP3A4

Suspected endocrine disrupting substances

“…The human version of the enzyme is important for enzymatic oxidative metabolism of both testosterone (Mäenpää et al 1993) and progesterone (Yamazaki and Shimada 1997). In addition CYP3A4 can metabolize 50 % of all drugs on the market today and it is probable that PBO has inhibitory effect on this enzyme (Moores et al 2011). If PBO has inhibitory effects on human CYP3A4 this could lead to serious effects.…”