Interactions of Pathogenic Escherichia coli with Gut Microbiota

Miliwebsky, Elizabeth; Jure, María Ángela; Farfán, Mauricio J.; Palermo, Marina S.

doi:10.1007/978-3-031-29882-0_12

Cited by 3 publications

(4 citation statements)

References 87 publications

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“…In particular, among the various mechanisms of colonization resistance, the direct production of SCFAs (i.e., acetate), secondary bile acids, and bacteriocins by microbial commensals, as well as of antimicrobial peptides and secretory IgA by host eukaryotic cells, were shown to be the most effective means to counteract ETEC invasion [ 121 ]. Conversely, some commensals (i.e., B. thetaiotaomicron ) make nutrients indirectly available for E. coli by degradation of complex polysaccharides or mucus layer and enhance the expression of E. coli virulence genes, thus promoting infection [ 120 , 122 ].…”

Section: Intestinal Pathogens and Gut Microbiotamentioning

confidence: 99%

“…To overcome the challenges posed by the limited susceptibility of mice to natural and experimental infection by EHEC and EPEC, potential approaches include the oral administration of broad-spectrum antibiotics to disrupt the balance of intestinal microbiota or the utilization of germ-free mice [ 122 ]. Stromberg and colleagues used germ-free mice colonized with altered Schaedler flora (ASF), a synthetic community composed of eight standard bacterial species [ 128 ], and infected them with EHEC 278F2 [ 129 ].…”

Section: Intestinal Pathogens and Gut Microbiotamentioning

confidence: 99%

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Animal and In Vitro Models as Powerful Tools to Decipher the Effects of Enteric Pathogens on the Human Gut Microbiota

Calvigioni,

Mazzantini,

Celandroni

et al. 2023

Microorganisms

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Examining the interplay between intestinal pathogens and the gut microbiota is crucial to fully comprehend the pathogenic role of enteropathogens and their broader impact on human health. Valid alternatives to human studies have been introduced in laboratory practice to evaluate the effects of infectious agents on the gut microbiota, thereby exploring their translational implications in intestinal functionality and overall health. Different animal species are currently used as valuable models for intestinal infections. In addition, considering the recent advances in bioengineering, futuristic in vitro models resembling the intestinal environment are also available for this purpose. In this review, the impact of the main human enteropathogens (i.e., Clostridioides difficile, Campylobacter jejuni, diarrheagenic Escherichia coli, non-typhoidal Salmonella enterica, Shigella flexneri and Shigella sonnei, Vibrio cholerae, and Bacillus cereus) on intestinal microbial communities is summarized, with specific emphasis on results derived from investigations employing animal and in vitro models.

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Section: Intestinal Pathogens and Gut Microbiotamentioning

confidence: 99%

Section: Intestinal Pathogens and Gut Microbiotamentioning

confidence: 99%

Animal and In Vitro Models as Powerful Tools to Decipher the Effects of Enteric Pathogens on the Human Gut Microbiota

Calvigioni,

Mazzantini,

Celandroni

et al. 2023

Microorganisms

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“…The experimental setups were then incubated (Section 2.2). The bacterial cells (EAEC and LAB) were evaluated for their competence for adhesion to the monolayers (2,4,8,12,16,20, 24 and 28 h).…”

Section: Bacterial Mode Of Infection and Tt Effects On Adhesionmentioning

confidence: 99%

“…Epidemiologically, EAEC has been implicated in both sporadic cases and outbreaks, affecting individuals across diverse age groups and geographical locations [7]. Its clinical relevance extends beyond acute gastroenteritis, as persistent infections have been associated with chronic sequelae, highlighting the need for a deeper understanding of the pathogen-host interactions [8,9]. EAEC, distinguished by its aggregative adherence and biofilm-forming capabilities, represents a significant public health concern globally [10,11].…”

Section: Introductionmentioning

confidence: 99%

Dynamic Interactions between Diarrhoeagenic Enteroaggregative Escherichia coli and Presumptive Probiotic Bacteria: Implications for Gastrointestinal Health

Agbemavor,

Buys

2023

Microorganisms

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This study delves into the temporal dynamics of bacterial interactions in the gastrointestinal tract, focusing on how probiotic strains and pathogenic bacteria influence each other and human health. This research explores adhesion, competitive exclusion, displacement, and inhibition of selected diarrhoeagenic Escherichia coli (D-EAEC) and potential probiotic strains under various conditions. Key findings reveal that adhesion is time-dependent, with both D-EAEC K2 and probiotic L. plantarum FS2 showing increased adhesion over time. Surprisingly, L. plantarum FS2 outperformed D-EAEC K2 in adhesion and exhibited competitive exclusion and displacement, with inhibition of adhesion surpassing competitive exclusion. This highlights probiotics’ potential to slow pathogen attachment when not in competition. Pre-infecting with L. plantarum FS2 before pathogenic infection effectively inhibited adhesion, indicating probiotics’ ability to prevent pathogen attachment. Additionally, adhesion correlated strongly with interleukin-8 (IL-8) secretion, linking it to the host’s inflammatory response. Conversely, IL-8 secretion negatively correlated with trans-epithelial electrical resistance (TEER), suggesting a connection between tight junction disruption and increased inflammation. These insights offer valuable knowledge about the temporal dynamics of gut bacteria interactions and highlight probiotics’ potential in competitive exclusion and inhibiting pathogenic bacteria, contributing to strategies for maintaining gastrointestinal health and preventing infections.

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Direct and macrophage stimulation mediated effects of active, inactive, and cell-free supernatant forms of Akkermansia muciniphila and Faecalibacterium duncaniae on hepcidin gene expression in HepG2 cells

Ahmadi Badi,

Malek,

Seyedi

et al. 2024

Arch Microbiol

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Interactions of Pathogenic Escherichia coli with Gut Microbiota

Cited by 3 publications

References 87 publications

Animal and In Vitro Models as Powerful Tools to Decipher the Effects of Enteric Pathogens on the Human Gut Microbiota

Animal and In Vitro Models as Powerful Tools to Decipher the Effects of Enteric Pathogens on the Human Gut Microbiota

Dynamic Interactions between Diarrhoeagenic Enteroaggregative Escherichia coli and Presumptive Probiotic Bacteria: Implications for Gastrointestinal Health

Direct and macrophage stimulation mediated effects of active, inactive, and cell-free supernatant forms of Akkermansia muciniphila and Faecalibacterium duncaniae on hepcidin gene expression in HepG2 cells

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