2014
DOI: 10.1016/j.jep.2014.07.023
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Interactions of Papua New Guinea medicinal plant extracts with antiretroviral therapy

Abstract: Ethnopharmacological relevance A substantial proportion of the population in Papua New Guinea (PNG) lives with human immunodeficiency virus (HIV). Treatment requires lifelong use of antiretroviral therapy (ART). The majority of people in PNG use traditional medicines (TM) derived from plants for all types of health promotions. Consequently, there is a concern that herb-drug interactions may impact the efficacy of ART. Herb-drug, or drug-drug, interactions occur at the level of metabolism through two major mech… Show more

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Cited by 13 publications
(10 citation statements)
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“…[ 14 , 15 ] Some of these issues such as stigma, side effects and forgetting are also common in the developed world. Issues particularly apparent in PNG include food insecurity[ 16 ], poor road systems, long distances between villages and ART prescribing sites, delays in on-time pill pick up as a result of road blocks, tribal fighting or lack of bus fare [ 17 ], widespread use of traditional medicinal plants [ 18 ] and drug stock-out. Furthermore, a variety of Christian denominations exists in PNG with different beliefs on HIV infection and ART, which may represent additional barriers to adherence.…”
Section: Introductionmentioning
confidence: 99%
“…[ 14 , 15 ] Some of these issues such as stigma, side effects and forgetting are also common in the developed world. Issues particularly apparent in PNG include food insecurity[ 16 ], poor road systems, long distances between villages and ART prescribing sites, delays in on-time pill pick up as a result of road blocks, tribal fighting or lack of bus fare [ 17 ], widespread use of traditional medicinal plants [ 18 ] and drug stock-out. Furthermore, a variety of Christian denominations exists in PNG with different beliefs on HIV infection and ART, which may represent additional barriers to adherence.…”
Section: Introductionmentioning
confidence: 99%
“…Succus was prepared in the field from 17 species of medicinal plants that were previously analysed for inhibition of CYPs [ 9 ]. Some of the plants were collected in more than one location.…”
Section: Resultsmentioning
confidence: 99%
“…Inhibition assays were performed as previously described [ 9 ]. In brief, plant extracts were added to human liver microsomes enriched in their respective CYP subtype (Celsis).…”
Section: Methodsmentioning
confidence: 99%
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“…Although the active compounds in TCMs have not been fully isolated and identified, a few have been found to be potential antivirals (14). Bioactive compounds extracted from natural products have characteristics similar to chemically synthesized medications and they can be easily assimilated and metabolized by the human body (15). Moreover, TCMs can be obtained from various organisms without the need for laborious or industrial chemosynthesis.…”
Section: Introductionmentioning
confidence: 99%