Interactions of nanoparticles bearing heparin or dextran covalently bound to poly(methyl methacrylate) with the complement system

Passirani, Catherine; Barratt, Gillian; Devissaguet, Jean‐Philippe; Labarre, Denis

doi:10.1016/s0024-3205(97)01175-2

Cited by 153 publications

(152 citation statements)

References 21 publications

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“…Particles below 10 nm are removed rapidly through extravasation and renal clearance. 53 In order to prolong plasma half-life, amphiphilic coatings are preferred, extending the circulation time of the particulates from minutes to hours, 104 thereby increasing the targeting capabilities of the contrast agent.…”

Section: Biocompatibilitymentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

et al. 2006

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Abstract-The field of molecular imaging has recently seen rapid advances in the development of novel contrast agents and the implementation of insightful approaches to monitor biological processes non-invasively. In particular, superparamagnetic iron oxide nanoparticles (SPIO) have demonstrated their utility as an important tool for enhancing magnetic resonance contrast, allowing researchers to monitor not only anatomical changes, but physiological and molecular changes as well. Applications have ranged from detecting inflammatory diseases via the accumulation of non-targeted SPIO in infiltrating macrophages to the specific identification of cell surface markers expressed on tumors. In this article, we attempt to illustrate the broad utility of SPIO in molecular imaging, including some of the recent developments, such as the transformation of SPIO into an activatable probe termed the magnetic relaxation switch.

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Section: Biocompatibilitymentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

et al. 2006

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“…The complement system plays a major role in the opsonization and recognition processes of foreign materials. Since heparin is an inhibitor of complement activation, nanoparticles bearing heparin covalently bound to poly (methyl methacrylate) and evaluated their interactions with complement was prepared (Passirani et al, 1998a). Nanoparticles bearing covalently bound dextran instead of heparin were weak activators of complement as compared with cross-linked dextran or bare poly (methyl methacrylate) nanoparticles.…”

Section: Polyacrylate-based Nanoparticles Applicable As Biomaterialsmentioning

confidence: 99%

“…The potent capacity for opsonization of the poly (methyl methacrylate) core was hidden by the protective effect of either polysaccharide, probably due to a dense brush -like structure. In the case of heparin nanoparticles, the "stealth" effect was probably increased by its inhibiting properties against complement activation (Passirani et al, 1998b).…”

Section: Polyacrylate-based Nanoparticles Applicable As Biomaterialsmentioning

confidence: 99%

Nanoparticles Based on Modified Polysaccharides

Namazi¹,

Fathi²,

Heydari³

2012

The Delivery of Nanoparticles

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“…Inhibition of complement activation by polymer surfaces bearing heparin was obtained, especially when heparin was bound by one end [24,25]. Long-circulating and very low complement activating NPs were also obtained from block copolymers composed of heparin and acrylic polymers (Hep-PMMA) [26,27]. It was also observed that despite a rather high amount of heparin bound to the NPs and injected to mice, no bleeding was observed and long circulation into blood was obtained, showing that the effects were localized to the surface of the NPs.…”

Section: Towards Biomimetic Strategiesmentioning

confidence: 99%

The Interactions between Blood and Polymeric Nanoparticles Depend on the Nature and Structure of the Hydrogel Covering the Surface

Labarre

2012

Polymers

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Polymeric surfaces in contact with blood in vivo are foreign bodies and are quickly isolated from blood by the non-specific defense systems. Nanoparticles (NP) used as drug carriers are normally quickly taken up by phagocytes and sequestered in liver and spleen to which they can deliver drugs. Long-circulating and/or low complement activating core-shell NPs can be obtained from PEO/PEG amphiphilic copolymers forming brush or loops on the surface. Core-shell NPs can also be obtained from polysaccharidic graft or block amphiphilic copolymers. Complement activation by the NPs and protein adsorption both depend on the structure, nature and molecular weight of the polysaccharide chains composing the shell. NPs showing low complement activation can be obtained if the polysaccharide on the surface is long and in a brush configuration. Fragile molecules such as hemoglobin or siRNA can be loaded and protected by appropriate brush shells without modifying the low complement activation properties.

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Interactions of nanoparticles bearing heparin or dextran covalently bound to poly(methyl methacrylate) with the complement system

Cited by 153 publications

References 21 publications

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

Nanoparticles Based on Modified Polysaccharides

The Interactions between Blood and Polymeric Nanoparticles Depend on the Nature and Structure of the Hydrogel Covering the Surface

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