Interactions of nanomaterials with the immune system

Hussain, Salik; Vanoirbeek, Jeroen; Hoet, Peter

doi:10.1002/wnan.166

Cited by 115 publications

(94 citation statements)

References 103 publications

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“…NMs can interact with immunocompetent cells and induce immunotoxicity (Zolnik et al, 2010;Di Gioacchino et al, 2011;Hussain et al, 2012;Dobrovolskaia and McNeil, 2016). Direct damage to immune cells by NMs leads to apoptosis and necrosis, while interactions of NMs with the immune response itself can change immune-specific signaling pathways, resulting in changes in immune cell function measured by expression of surface markers, cytokine production, cell differentiation and immune activation (Hartung and Corsini, 2013).…”

Section: Mechanisms Of Immunotoxicitymentioning

confidence: 99%

Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing?

Dušinská

Tulinská

Yamani

et al. 2017

Food and Chemical Toxicology

116

101

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a b s t r a c tThe unique properties of nanomaterials (NMs) are beneficial in numerous industrial and medical applications. However, they could also induce unintended effects. Thus, a proper strategy for toxicity testing is essential in human hazard and risk assessment. Toxicity can be tested in vivo and in vitro; in compliance with the 3Rs, alternative strategies for in vitro testing should be further developed for NMs. Robust, standardized methods are of great importance in nanotoxicology, with comprehensive material characterization and uptake as an integral part of the testing strategy. Oxidative stress has been shown to be an underlying mechanism of possible toxicity of NMs, causing both immunotoxicity and genotoxicity. For testing NMs in vitro, a battery of tests should be performed on cells of human origin, either cell lines or primary cells, in conditions as close as possible to an in vivo situation. Novel toxicity pathways, particularly epigenetic modification, should be assessed along with conventional toxicity testing methods. However, to initiate epigenetic toxicity screens for NM exposure, there is a need to better understand their adverse effects on the epigenome, to identify robust and reproducible causal links between exposure, epigenetic changes and adverse phenotypic endpoints, and to develop improved assays to monitor epigenetic toxicity.

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Section: Mechanisms Of Immunotoxicitymentioning

confidence: 99%

Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing?

Dušinská

Tulinská

Yamani

et al. 2017

Food and Chemical Toxicology

116

101

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“…108,110 Nanoparticles can also interact with the immune system, provoking other side effects in humans. 113 All these analyses will produce datasets that can inform the design and construction of computational models and simulations that will attempt to predict the toxicity of nanoparticles. Nanoinformatics must help to design and implement predictive models characterizing the interactions involved in nanoparticle exposure, the aggregate and cumulative hazards, and the health and environmental risks on various tissues and body organs and systems.…”

Section: Clinical Trials and Toxicitymentioning

confidence: 99%

Nanoinformatics: a new area of research in nanomedicine

Maojo¹,

Fritts²,

Iglesia³

et al. 2012

IJN

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Over a decade ago, nanotechnologists began research on applications of nanomaterials for medicine. This research has revealed a wide range of different challenges, as well as many opportunities. Some of these challenges are strongly related to informatics issues, dealing, for instance, with the management and integration of heterogeneous information, defining nomenclatures, taxonomies and classifications for various types of nanomaterials, and research on new modeling and simulation techniques for nanoparticles. Nanoinformatics has recently emerged in the USA and Europe to address these issues. In this paper, we present a review of nanoinformatics, describing its origins, the problems it addresses, areas of interest, and examples of current research initiatives and informatics resources. We suggest that nanoinformatics could accelerate research and development in nanomedicine, as has occurred in the past in other fields. For instance, biomedical informatics served as a fundamental catalyst for the Human Genome Project, and other genomic and -omics projects, as well as the translational efforts that link resulting molecular-level research to clinical problems and findings.

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“…[1][2][3][4][5][6][7] Lymphatic vessels have evolved to drain pathogens into lymph nodes, which provide a first line of defense against invading viruses and the initiation/ subsequent direction of adaptive immune responses for the removal of pathogens. [8][9][10] Nodal antigen-presenting cells (APCs) detect danger signals through pattern recognition receptors and initiate multiple arms of innate immune response such as the activation of inflammasomes and the secretion of proinflammatory cytokines and type I interferons (IFNs).…”

Section: Introductionmentioning

confidence: 99%

Aminated nanomicelles as a designer vaccine adjuvant to trigger inflammasomes and multiple arms of the innate immune response in lymph nodes

Song

Phuengkham

Kim

et al. 2017

IJN

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In this study, we suggest a designer vaccine adjuvant that can mimic the drainage of pathogens into lymph nodes and activate innate immune response in lymph nodes. By the amination of multivalent carboxyl groups in poly-(γ-glutamic acid) (γ-PGA) nanomicelles, the size was reduced for rapid entry into lymphatic vessels, and the immunologically inert nanomicelles were turned into potential activators of inflammasomes. Aminated γ-PGA nanomicelles (aPNMs) induced NLRP3 inflammasome activation and the subsequent release of proinflammatory IL-1β. The NLRP3-dependent inflammasome induction mechanism was confirmed through enzyme (cathepsin B and caspase-1) inhibitors and NLRP3 knockout mice model. After the aPNMs were combined with a clinically evaluated TLR3 agonist, polyinosinic–polycytidylic acid sodium salt (aPNM-IC), they triggered multiple arms of the innate immune response, including the secretion of pro-inflammatory cytokines by both inflammasomes and an inflammasome-independent pathway and the included type I interferons.

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Interactions of nanomaterials with the immune system

Cited by 115 publications

References 103 publications

Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing?

Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing?

Nanoinformatics: a new area of research in nanomedicine

Aminated nanomicelles as a designer vaccine adjuvant to trigger inflammasomes and multiple arms of the innate immune response in lymph nodes

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