Interactions of hemoglobin Lepore (δβ hybrid hemoglobin) with various hemoglobinopathies: A molecular and hematological characteristics and differential diagnosis

Molecular basis and hematological features of hemoglobin variants in Southern Thailand

“…Seven hemoglobin variants found in [32,37,[42][43][44][45][46] Northern Thai case [28,47,48] Hb C Data from previous studies this study were previously reported in other regions of Thailand, except for Hb O-Indonesia (Table 4). Hb O-Indonesia (a 116 Glu-Lys ), also known as Hb Burginese-X or Hb Oliviere, has been identified in Indonesian, Indian, Iranian, Italian, and Chinese people [10,17,[19][20][21][22][23][24].…”

Presumptive diagnosis of common haemoglobinopathies in Southeast Asia using a capillary electrophoresis system

“…This capillary electrophoresis is therefore useful for screening of the Hb Lepore variant in Southeast Asia where Hb E is prevalent. We have recently reported a high prevalence and multiple origins of this δβ‐thalassaemia defect in the Thai population (Chaibunruang et al. , 2010).…”

“…, 2001b, 2005), Hb C (β 6GAG‐AAG,Glu‐Lys ) (Sanchaisuriya et al. , 2001) and Hb Lepore (δβ hybrid haemoglobin) (Chaibunruang et al. , 2010).…”

Diagnosis of common hemoglobinopathies among South East Asian population using capillary isoelectric focusing system

“…Unfortunately, we found that a δβ hybrid Hb, the Hb Lepore, comigrated with Hb F at R6, leading to a falsely elevated Hb F (10.07% instead of around 3–5% described previously) (Figure S3a) . Therefore, Hb Lepore could be misinterpreted as Hb F on the V8 cIEF system.…”