Interactions of Fullerene‐Polyglycerol Sulfates at Viral and Cellular Interfaces

Donskyi, Ievgen S.; Drüke, Moritz; Silberreis, Kim; Lauster, Daniel; Ludwig, Kai; Kühne, Christian; Unger, Wolfgang; Böttcher, Christoph; Herrmann, Andreas; Dernedde, Jens; Adeli, Mohsen; Haag, Rainer

doi:10.1002/smll.201800189

Cited by 31 publications

(34 citation statements)

References 46 publications

(60 reference statements)

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“…This was through effective viral association with binding simulated to be strong and multivalent to the VAL repeating units [ 165 ]. Water-Soluble fullerene-polyglycerol sulfates prevented interaction of vesicular stomatitis virus coat glycoprotein with baby hamster kidney cells [ 166 ]. Lysenko et al (2018) proposed that one of the main and direct mechanisms of nanoparticle-mediated antiviral activity is linked to local-field action against the receptors at the virus surface [ 50 ].…”

Section: Antiviral Mechanism Of Nanoparticlesmentioning

confidence: 99%

Antiviral Potential of Nanoparticles—Can Nanoparticles Fight Against Coronaviruses?

et al. 2020

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Infectious diseases account for more than 20% of global mortality and viruses are responsible for about one-third of these deaths. Highly infectious viral diseases such as severe acute respiratory (SARS), Middle East respiratory syndrome (MERS) and coronavirus disease (COVID-19) are emerging more frequently and their worldwide spread poses a serious threat to human health and the global economy. The current COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of 27 July 2020, SARS-CoV-2 has infected over 16 million people and led to the death of more than 652,434 individuals as on 27 July 2020 while also causing significant economic losses. To date, there are no vaccines or specific antiviral drugs to prevent or treat COVID-19. Hence, it is necessary to accelerate the development of antiviral drugs and vaccines to help mitigate this pandemic. Non-Conventional antiviral agents must also be considered and exploited. In this regard, nanoparticles can be used as antiviral agents for the treatment of various viral infections. The use of nanoparticles provides an interesting opportunity for the development of novel antiviral therapies with a low probability of developing drug resistance compared to conventional chemical-based antiviral therapies. In this review, we first discuss viral mechanisms of entry into host cells and then we detail the major and important types of nanomaterials that could be used as antiviral agents. These nanomaterials include silver, gold, quantum dots, organic nanoparticles, liposomes, dendrimers and polymers. Further, we consider antiviral mechanisms, the effects of nanoparticles on coronaviruses and therapeutic approaches of nanoparticles. Finally, we provide our perspective on the future of nanoparticles in the fight against viral infections.

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Section: Antiviral Mechanism Of Nanoparticlesmentioning

confidence: 99%

Antiviral Potential of Nanoparticles—Can Nanoparticles Fight Against Coronaviruses?

et al. 2020

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“…Synthetic polymers can be obtained with great uniformity, accurate molecular weight, controlled topology, and precisely selected end groups [11]. Moreover, the combination of polymeric materials with, for instance, dendrimers [12,13,14], liposomes [15,16], or inorganic nanoparticles (INPs) such as silicon dioxide nanoparticles [17], magnetic nanoparticles [18], plasmonic nanoparticles [19], carbon nanotubes [20], carbon dots [21], fullerene [22] or others, gives hybrid nanomaterials with additional and extraordinary properties. For the case of INPs, examples of these enhanced properties are the magnetic behavior obtained by combining magnetic nanoparticles with polymer matrices, or the more reliably protection of drug cargo displayed by mesoporous silica/polymer nanoparticles compared with purely organic nanomaterials [23].…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis and Architectures of Hybrid Nanomaterials for Therapy and Diagnosis Applications

2018

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Hybrid nanomaterials based on inorganic nanoparticles and polymers are highly interesting structures since they combine synergistically the advantageous physical-chemical properties of both inorganic and polymeric components, providing superior functionality to the final material. These unique properties motivate the intensive study of these materials from a multidisciplinary view with the aim of finding novel applications in technological and biomedical fields. Choosing a specific synthetic methodology that allows for control over the surface composition and its architecture, enables not only the examination of the structure/property relationships, but, more importantly, the design of more efficient nanodevices for therapy and diagnosis in nanomedicine. The current review categorizes hybrid nanomaterials into three types of architectures: core-brush, hybrid nanogels, and core-shell. We focus on the analysis of the synthetic approaches that lead to the formation of each type of architecture. Furthermore, most recent advances in therapy and diagnosis applications and some inherent challenges of these materials are herein reviewed.

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“…The second way to suppress viruses is blocking their penetration and entry to host cells by changing the cell surface membrane and protein structures. Haag and his collaborators have synthesized a series of water-soluble fullerene-polyglycerol sulfates (FPS) with different fullerene and polymer weight ratios and varying numbers of polyglycerol sulfate branches [122]. The combination of polyanionic branches with a solvent exposed variable hydrophobic core in FPS proves to be superior to analogs possessing only one of these features in preventing interaction of vesicular stomatitis virus coat glycoprotein with baby hamster kidney cells.…”

Section: The Antiviral Mechanisms Of Functional Nanoparticlesmentioning

confidence: 99%

An overview of functional nanoparticles as novel emerging antiviral therapeutic agents

Chen

Liang

2020

Materials Science and Engineering: C

195

158

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Research on highly effective antiviral drugs is essential for preventing the spread of infections and reducing losses. Recently, many functional nanoparticles have been shown to possess remarkable antiviral ability, such as quantum dots, gold and silver nanoparticles, nanoclusters, carbon dots, graphene oxide, silicon materials, polymers and dendrimers. Despite their difference in antiviral mechanism and inhibition efficacy, these functional nanoparticles-based structures have unique features as potential antiviral candidates. In this topical review, we highlight the antiviral efficacy and mechanism of these nanoparticles. Specifically, we introduce various methods for analyzing the viricidal activity of functional nanoparticles and the latest advances in antiviral functional nanoparticles. Furthermore, we systematically describe the advantages and disadvantages of these functional nanoparticles in viricidal applications. Finally, we discuss the challenges and prospects of antiviral nanostructures. This topic review covers 132 papers and will enrich our knowledge about the antiviral efficacy and mechanism of various functional nanoparticles.

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Interactions of Fullerene‐Polyglycerol Sulfates at Viral and Cellular Interfaces

Cited by 31 publications

References 46 publications

Antiviral Potential of Nanoparticles—Can Nanoparticles Fight Against Coronaviruses?

Antiviral Potential of Nanoparticles—Can Nanoparticles Fight Against Coronaviruses?

Design, Synthesis and Architectures of Hybrid Nanomaterials for Therapy and Diagnosis Applications

An overview of functional nanoparticles as novel emerging antiviral therapeutic agents

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