Interactions of Clay and Clay Minerals with the Human Health

Gomes, Celso; Rautureau, Michel; Gomes, Jorge Hamilton; Silva, Eduardo A. F.

doi:10.1007/978-3-030-65706-2_7

Cited by 8 publications

(1 citation statement)

References 344 publications

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“…Clay minerals, characterized by their submicron size, high specific surface area, high adsorption capacity, chemical inertia, and multilayer organization of 0.7-1 nm-thick sheets, have been subject to extensive investigation owing to their DOI: 10.1002/smll.202306169 wide-ranging applications in the field of biomedicine. [1] Derived primarily from the weathering and alteration processes of abundant silicate minerals, such as feldspars, micas, and volcanic rocks, [2,3] these minerals offer the distinct advantage of low toxicity and good biocompatibility with the human body, making them ideal candidates for the development of specialized clay-based therapeutics. [4] The layered structure of clay minerals, consisting of stacked tetrahedral and octahedral layers, [1] exemplifies the 1:1 organization (one octahedral layer attached to one tetrahedral layer) and the 2:1 organization (where two tetrahedral sheets are linked to each side of an octahedron), which contribute to their unique properties.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances of Halloysite Nanotubes in Biomedical Applications

Jiang,

Sun,

Liu

et al. 2023

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Halloysite nanotubes (HNTs) have emerged as a highly regarded choice in biomedical research due to their exceptional attributes, including superior loading capacity, customizable surface characteristics, and excellent biocompatibility. HNTs feature tubular structures comprising alumina and silica layers, endowing them with a large surface area and versatile surface chemistries that facilitate selective modifications. Moreover, their substantial pore volume and wide range of pore sizes enable efficient entrapment of diverse functional molecules. This comprehensive review highlights the broad biomedical application spectrum of HNTs, shedding light on their potential as innovative and effective therapeutic agents across various diseases. It emphasizes the necessity of optimizing drug delivery techniques, developing targeted delivery systems, rigorously evaluating biocompatibility and safety through preclinical and clinical investigations, exploring combination therapies, and advancing scientific understanding. With further advancements, HNTs hold the promise to revolutionize the pharmaceutical industry, opening new avenues for the development of transformative treatments.

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