Interactions of Cadmium with Copper, Iron, Zinc, and Manganese in Ovine Tissues

Doyle, John; Pfander, W. H.

doi:10.1093/jn/105.5.599

Cited by 63 publications

(22 citation statements)

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“…It has been reported that excessive concentrations of hepatic Zn reveal a high Cd exposure in marine vertebrates, such as birds and sea mammals. According to Doyle and Pfander (1975), lower slope constants (Zn/Cd) for liver than those for kidney have been observed in the case of animals unexposed to high concentrations of Cd.…”

Section: Discussionmentioning

confidence: 99%

Age, sex and spatial dependent variations in heavy metals levels in the Glaucous Gulls (Larus hyperboreus) from the Bjørnøya and Jan Mayen, Arctic

Malinga

Szefer

Gabrielsen

2009

Environ Monit Assess

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Heavy metals (Cd, Cu, Fe, Mn and Zn) concentrations were determined in different tissues (muscle, kidney, liver, brain, gonads, heart and feathers) of Glaucous Gulls (Larus hyperboreus) from Bjørnøya and Jan Mayen. The age and spatial dependent variations in heavy metals were quantified and interpreted in view of the three chemometric techniques, i.e. non-parametric Mann-Whitney U test, redundancy gradient analysis and detrended correspondence analysis. The Glaucous Gulls from Bjørnøya contained significantly higher (p < 0.05) levels of Cd, Cu and Zn than those inhabited Jan Mayen. Adult birds were characterized by greater (p < 0.01) concentration of muscle, hepatic and renal heavy metals in comparison to chicks. Insignificantly higher slope constant Zn/Cd for the liver than for the kidney may reflect insignificant Cd exposure. Estimate of transfer factor (TF) allows us to assess variations in heavy metal concentrations during the individual development of Glaucous Gulls. It may be stated that there is a distinct increase of bioaccumulation of all the studied metals during subsequent stages of the bird life.

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Section: Discussionmentioning

confidence: 99%

Age, sex and spatial dependent variations in heavy metals levels in the Glaucous Gulls (Larus hyperboreus) from the Bjørnøya and Jan Mayen, Arctic

Malinga

Szefer

Gabrielsen

2009

Environ Monit Assess

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“…Cd-Mn was inversely correlated in urine, but positively in feces. Cd-Mn association has been reported in sheep exposed to high dietary Cd [13] and in humans after low levels of environmental Cd exposure [35]. Although the statistical significance of these associations was low, the evidence suggests that the two elements interact in vivo.…”

Section: Cadmiummentioning

confidence: 98%

Correlations of Trace Element Levels in the Diet, Blood, Urine, and Feces in the Chinese Male

Wang

Liu

et al. 2011

Biol Trace Elem Res

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In order to explore the associations between trace elements in dietary intake and the other three biological media (blood, urine, or feces) and inter-element interactions among the latter, we simultaneously collected 72-h diet duplicates, whole blood, and 72-h urine and feces from 120 free-living healthy males in China. Correlations among the toxic (cadmium [Cd], lead [Pb]), and nutritionally essential (zinc [Zn], copper [Cu], iron [Fe], manganese [Mn], selenium [Se], iodine [I]) elements were evaluated using Spearman rank correlation analysis based on analytical data determined by inductively coupled plasma-mass spectrometry. Dietary Cd intakes were highly correlated with the fecal Cd and blood Cd levels. Inverse correlations were found for Fe-Cd and Fe-Pb in both diet versus blood and diet versus feces. Cd-Zn and Cd-Se were significantly directly correlated in the urine and feces. Cd-Se and Pb-Se were negatively correlated in blood. In addition, there existed an extremely significant association between urinary Se and urinary I. Moreover, the other two highly direct correlations were found for Se-Fe and for I-Fe in urine. Improved knowledge regarding their mutual associations is considered to be of fundamental importance to understand more the complex interrelationships in trace element metabolism.

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“…Manganese has been associated with increased intestinal uptake of cadmium [24]. Additionally, drinking water cadmium has been shown to increase renal and hepatic manganese in rats, whereas dietary levels at 60 mg/kg Cd decreased hepatic manganese [34,35]. Japanese quail with manganese-supplemented diets had decreased long-term retention of Cd [36].…”

Section: Cd-mn-se-hg-as Clustermentioning

confidence: 99%

Biogeochemical interactions affecting hepatic trace element levels in aquatic birds

Möller

1996

Enviro Toxic and Chemistry

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Abstract-Knowledge of elemental interactions is important to the toxicological assessment of wildlife in the geochemical environment. This study determines the concentrations of Al, As, B, Ba, Be, Cd, Cr, Cu, Fe, Pb, Li, Mg, Mn, Hg, Mo, Ni, Se, Ag, V, and Zn in aquatic bird liver, fish liver, whole bivalves, insects, and waters in several aquatic ecosystems in northern California. There is evidence of strong in vivo and environmental interactions, including the observation of manganese as a possible cofactor or indicator in selenium bioaccumulation. The nearest neighbor selenium correlation in aquatic bird liver tissue that results from this work is Cd-Mn-Se-HgAs. The correlation of liver selenium to manganese in vivo and the result that the majority of the variance in liver selenium concentration is contained in the manganese term of the regression model relating Se to Cd, Mn, and Hg is new knowledge in the study of aquatic birds. A linear relationship between liver selenium and environmental manganese (water and sediment) is found in the data, suggesting a water chemistry compartmentalization or activation of toxicants. Alternatively, the hepatic concentrations of selenium, manganese, and iron suggest induction of enzymes in response to oxidative stress.

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Interactions of Cadmium with Copper, Iron, Zinc, and Manganese in Ovine Tissues

Cited by 63 publications

References 0 publications

Age, sex and spatial dependent variations in heavy metals levels in the Glaucous Gulls (Larus hyperboreus) from the Bjørnøya and Jan Mayen, Arctic

Age, sex and spatial dependent variations in heavy metals levels in the Glaucous Gulls (Larus hyperboreus) from the Bjørnøya and Jan Mayen, Arctic

Correlations of Trace Element Levels in the Diet, Blood, Urine, and Feces in the Chinese Male

Biogeochemical interactions affecting hepatic trace element levels in aquatic birds

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