Interactions of a standardized flavonoid fraction from Tilia americana with Serotoninergic drugs in elevated plus maze

Noguerón-Merino, M.C.; Jiménez-Ferrer, Enrique; Román-Ramos, Rubén; Zamilpa, Alejandro; Tortoriello, Jaime; Herrera-Ruíz, Maribel

doi:10.1016/j.jep.2015.01.029

Cited by 32 publications

(27 citation statements)

References 36 publications

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“…The flavonoid mixture, composed of quercetin, isoquercitrin and rutin, was identified as partially responsible for the found activity, suggesting a synergy between these and other likely constituents in relation to their anxiolytic and sedative-like activities, which are mediated by GABAergic and serotonergic systems. Our results are in agreement to that reported in the literature, where the anxiolytic effect of a flavonoid standarized fraction obtained from a methanol extract of T. americana was antagonized in the presence of WAY-100635, 14 both studies give evidence that serotonergic system participates in the anxiolytic and sedative-like effects of this medicinal species.…”

Section: Discussionsupporting

confidence: 93%

“…mexicana collected from three different regions of Mexico produce anxiolytic and sedative-like effect equivalent to those of Tilia species previously reported and thus underline the medicinal properties accredited to the genus. 7,14,17,18 Moreover, no difference in the tranquilizing activity was found between Tilia leaves and inflorescences. These findings reinforce the medicinal properties mentioned for Tilia and provide evidence that leaves can also be used for therapeutic purposes.…”

Section: Discussionmentioning

confidence: 88%

“…7 The precise mechanisms of action of flavonoids might differ depending on the chemical structure and pharmacological activity, but regarding the anti-anxiety and sedative-like activities, the involvement of the GABAergic and serotonergic systems is typically reported. 12,14,29,30 Nevertheless, many flavonoids have been described to produce depressant activity on the Central Nervous System mediated by other than GABA A /benzodiazepine or GABA/non benzodiazepinic receptors. 14,31,32 In the present study, a crude methanol extract and a flavonoid mixture of T. americana var.…”

Section: Discussionmentioning

confidence: 99%

“…12,14,29,30 Nevertheless, many flavonoids have been described to produce depressant activity on the Central Nervous System mediated by other than GABA A /benzodiazepine or GABA/non benzodiazepinic receptors. 14,31,32 In the present study, a crude methanol extract and a flavonoid mixture of T. americana var. mexicana leaves produced an anxiolytic-like effect that was reverted in presence of the benzodiazepine and 5-HT 1A receptor antagonists, flumazenil (5 mg/kg, i.p.)…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that natural flavonoids possess a selective and relatively mild affinity for benzodiazepine receptors, 12 but some of them might also produce their tranquilizing activity by acting on serotonergic receptors. 13,14 In a preliminary study, the extract of T. americana var. mexicana inflorescences produced anxiolytic and sedative-like effects where, at the same 100 mg/kg, i.p.…”

Section: 11mentioning

confidence: 99%

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Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

Aguirre-Hernández

González-Trujano

Terrazas

et al. 2016

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: 11mentioning

confidence: 99%

See 3 more Smart Citations

Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

Aguirre-Hernández

González-Trujano

Terrazas

et al. 2016

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Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre‐clinical studies published from 2010 to 2020

Meneses

Valdés

Garrido-Suárez³

et al. 2023

Phytotherapy Research

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Anxiety disorders are prevalent conditions in the world population, whose standard approaches include pharmacotherapy, psychotherapy, and combinations of these interventions. Different classes of psychopharmaceuticals are recommended as the first line of drugs to treat these disorders, which can have several adverse effects, treatment resistance, dependence, and drug–drug interactions making it necessary to search for new therapeutic agents. In particular, diazepam (DZP), a prototype drug from the group of benzodiazepines, has been commonly used and evaluated for its efficacy and safety in different anxiety disorders in clinical trials. DZP is also the most widely used reference standard in in vivo pharmacological assays of natural compounds. However, translating the results obtained in different rodent species and physiological anxiety tests instead of psychopathological animal models that can be of clinical application remains challenging. A systematic review of scientific articles published between 2010 and 2020 that included in vivo pre‐clinical tests to define the anxiolytic, sedative and/or hypnotic effect of flower extracts is proposed. PRISMA and Rayyan were used for the selection of studies using four databases (Pubmed, Scopus, Web of Science, and QInsight), using the keywords: “Animals,” “Anxiolytic,” “Diazepam,” “Elevated Plus Maze,” “Flower Extracts,” “Insomnia,” “In vivo,” “Mice,” “Open Field Test,” “Pre clinical” and “Sedative.” The characteristics of anxiety studies in animal models, other studies related to locomotor activity, and the hypnotic effect of the extracts were compiled. Twenty‐four articles were included, 21 of them performed the animal model of anxiety‐like behavior of the elevated plus maze, seven the open field test, and six the light–dark box test. The locomotor activity was evaluated in 10 studies after the administration of the extracts to the animals to define their sedative effect, where only one defined that the extract (Matricaria chamomilla) had a sedative effect. The plants declared with this type of activity were Achyranthes aspera, Alcea aucheri, Brassica nigra, Cananga odorata, Carthamus tinctorius, Chrysanthemum indicum, Citrus aurantium, Couroupita guianensis, Echium amoenum, Erythrina berteroana, Gardenia jasminoides, Hibiscus tilliaceus, Lavandula officinalis, Lawsonia inermis, Matricaria chamomilla, Melia azedarach, Nerium oleander, Passiflora incarnata, Plumeria rubra, Salix aegyptiaca, Syzygium aromaticum, Tagetes erecta, Tilia americana. Although this review showed that some flower extracts have an anxiolytic effect as effective as diazepam, their therapeutic utility in anxiety disorders remains to be extensively demonstrated. Hence, more reliable and predictive behavioral tests and appropriate strategies for the experimental designs are needed to obtain more conclusive evidence with clinical significance.

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Active compounds and anti-inflammatory activity of the methanolic extracts of the leaves and callus from Tilia americana var. mexicana propagated plants

Flores-Sánchez

Cruz-Sosa

Zamilpa

et al. 2019

Plant Cell Tiss Organ Cult

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Interactions of a standardized flavonoid fraction from Tilia americana with Serotoninergic drugs in elevated plus maze

Cited by 32 publications

References 36 publications

Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre‐clinical studies published from 2010 to 2020

Active compounds and anti-inflammatory activity of the methanolic extracts of the leaves and callus from Tilia americana var. mexicana propagated plants

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