Interactions of a prenylated flavonoid from Dalea elegans with fluconazole against azole- resistant Candida albicans

Barceló, Sebastián; Peralta, Mariana Andrea; Calise, M; Finck, Soledad; Ortega, Guillermo J.; Díez, Roberto A.; Cabrera, José Luis; Pérez, Cristina

doi:10.1016/j.phymed.2017.05.001

Cited by 16 publications

(20 citation statements)

References 22 publications

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“…For instance, the levels of phenylpropanoids fluctuate greatly in response to extracellular circumstance with numerous factors including light irradiation [5] as well as other abiotic stresses including nitrogen deficiency, cold and drought [6]. In addition, they have been demonstrated to be very important with regard to biotic stresses with evidence accumulating for the roles of flavones and isoflavones in the response of medicago to fungal pathogens [7], while the presence of maysin in maize confers resistance against the major pest Helicoverpea zea [8 ]. The function of flavonoids has recently been comprehensively reviewed [2 ], so we will not cover this here.…”

Section: Introductionmentioning

confidence: 99%

Conservation and diversification of flavonoid metabolism in the plant kingdom

Wen

Alseekh

Fernie

2020

Current Opinion in Plant Biology

161

113

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Flavonoids are by far the largest class of polyphenols with huge structural and functional diversity. However, the mystery regarding the exact evolutionary pressures which lead to the amazing diversity in plant flavonoids has yet to be completely uncovered. Here we review recent advances in understanding the conservation and diversification of flavonoid pathway from algae and early land plants to vascular plants including the model plant Arabidopsis and economically important species such as cereals, legumes, and medicinal plants. Studies on the origin and evolution of R2R3-MYB regulatory system demonstrated its highly conserved function of regulating flavonoid production in land plants and this innovation appears to have been crucial in boosting the overall levels of these compounds in land plants. Convergent evolution has occurred as different flavonoids independently which emerged in distant taxa resulting in similar defense and tolerance characteristics against environmental stresses. Future studies on an increasing number of plant species taking advantage of newly developed genomic and metabolite profiling technologies are envisaged to provide comprehensive insight into flavonoid biosynthesis as well as pathway diversification and the underlying evolutionary mechanisms.

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Section: Introductionmentioning

confidence: 99%

Conservation and diversification of flavonoid metabolism in the plant kingdom

Wen

Alseekh

Fernie

2020

Current Opinion in Plant Biology

161

113

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“…Dado que los azoles son recursos terapéuticos valiosos, convendría seguir utilizándolos, para lo cual sería necesario recuperar su eficacia. Así, es crucial la búsqueda de nuevas estrategias enmarcadas en esta temática (Gumbo, 2011;Barceló et al, 2017). Una de las estrategias exploradas consiste en revertir la resistencia a los azoles mediada por bombas que los expulsan hacia el exterior de las células del microorganismo (Peralta et al, 2012;Barceló et al, 2014).…”

Section: Infecciones Comunes En Adolescentesunclassified

“…El desarrollo de las vacunas, por ejemplo, ha sido crucial para erradicar muchas de las citadas infecciones. Los antimicrobianos juegan también un papel fundamental en el tratamiento de las infecciones, y se justifica la investigación acerca de ellos por distintos motivos, crucialmente el desarrollo de resistencia (Gumbo, 2011;Pérez et al, 2003a, Barceló et al, 2017.…”

Section: Introducción Fundamentación Y Antecedentesunclassified

Infecciones, curcumina y 8PP: educación y divulgación científica en laboratorios escolares

Pérez

Farah

2023

Rev. Educación

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Antecedentes. La serie pedagógica De la universidad a la escuela compila actividades docentes innovadoras que incluyen formación y difusión científica en escuelas primarias y secundarias argentinas. Objetivo. Desarrollar una actividad docente innovadora que expanda las realizadas anteriormente e incluya clases y trabajos prácticos afines en laboratorios escolares. Enfoque y actividades. En un temario de infecciones, se relacionaron las áreas de biología y química con estudiantes que cursaban primero, segundo o cuarto año de una escuela municipal de Buenos Aires (Argentina). Se repasaron, seleccionaron y relacionaron conocimientos de la curricula escolar; luego se agregó información relacionada extraída de los programas universitarios de farmacología y microbiología, además de datos científicos recientes. Se expandió y profundizó el temario de infecciones comunes en adolescentes, particularmente las candidiasis. Se informó sobre Candida albicans resistente a medicamentos, su relevancia médica y la búsqueda de nuevos medicamentos para solucionar el problema sanitario. Como ejemplos de potenciales medicamentos antimicóticos de origen vegetal para combatir Candida albicans resistente a azoles, se tomó en forma comparativa la curcumina y el 8PP, en función de su similar actividad antimicrobiana, aspecto físico y conocimientos previos del alumnado. La primera está contenida en el condimento popular cúrcuma o azafrán de la India; se seleccionó este último por ser conocido por el alumnado. El 8PP, extraído de las raíces de la leguminosa Dalea elegans, continúa siendo investigado en estrategias farmacológicas en Argentina. En este trabajo docente se diseñaron y desarrollaron clases teóricas y prácticas interactivas, adecuadas a los temas tratados y al laboratorio escolar. Resultados. Se desarrolló una propuesta innovadora docente que integra y actualiza distintos conocimientos científicos relacionados con la búsqueda de nuevos medicamentos antimicóticos. Conclusiones. Esta experiencia amplía y enriquece la curricula docente del nivel secundario, tanto en criterios científicos como en datos provenientes de ámbitos argentinos y extranjeros, siguiendo recomendaciones derivadas de su reconocida y valorada originalidad.

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“…Flavonoids are a large group of water soluble secondary metabolites that are widely distributed in plants. Flavonoids play a diversity of roles in extant plants such as floral coloration for attracting pollinators ( Schaefer et al., 2004 ), protection against biotic and abiotic stresses including UV irradiation ( Qian et al., 2021 ), nitrogen deficiency ( Lea et al., 2007 ), drought ( Ma et al., 2014 ), cold ( Sudheeran et al., 2018 ), fungal pathogens ( Barcelóet al., 2017 ), and pest ( Casas et al., 2016 ). In addition, flavonoids are also beneficial for human health due to their antioxidant activities against free radicals, subsequently reducing the risk of chronic diseases, especially cancer ( Chen and Chen, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

RNA-Seq reveals the key pathways and genes involved in the light-regulated flavonoids biosynthesis in mango (Mangifera indica L.) peel

Qian

Yang

et al. 2023

Front. Plant Sci.

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IntroductionFlavonoids are important water soluble secondary metabolites in plants, and light is one of the most essential environmental factors regulating flavonoids biosynthesis. In the previous study, we found bagging treatment significantly inhibited the accumulation of flavonols and anthocyanins but promoted the proanthocyanidins accumulation in the fruit peel of mango (Mangifera indica L.) cultivar ‘Sensation’, while the relevant molecular mechanism is still unknown.MethodsIn this study, RNA-seq was conducted to identify the key pathways and genes involved in the light-regulated flavonoids biosynthesis in mango peel.ResultsBy weighted gene co-expression network analysis (WGCNA), 16 flavonoids biosynthetic genes were crucial for different flavonoids compositions biosynthesis under bagging treatment in mango. The higher expression level of LAR (mango026327) in bagged samples might be the reason why light inhibits proanthocyanidins accumulation in mango peel. The reported MYB positively regulating anthocyanins biosynthesis in mango, MiMYB1, has also been identified by WGCNA in this study. Apart from MYB and bHLH, ERF, WRKY and bZIP were the three most important transcription factors (TFs) involved in the light-regulated flavonoids biosynthesis in mango, with both activators and repressors. Surprisingly, two HY5 transcripts, which are usually induced by light, showed higher expression level in bagged samples.DiscussionOur results provide new insights of the regulatory effect of light on the flavonoids biosynthesis in mango fruit peel.

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Interactions of a prenylated flavonoid from Dalea elegans with fluconazole against azole- resistant Candida albicans

Cited by 16 publications

References 22 publications

Conservation and diversification of flavonoid metabolism in the plant kingdom

Conservation and diversification of flavonoid metabolism in the plant kingdom

Infecciones, curcumina y 8PP: educación y divulgación científica en laboratorios escolares

RNA-Seq reveals the key pathways and genes involved in the light-regulated flavonoids biosynthesis in mango (Mangifera indica L.) peel

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