Interactions Between Total Plasma Homocysteine, Oxidized LDL Levels, Thiolactonase Activities and Dietary Habits in Tunisian Diabetic Patients

Koubaa, Nadia; Smaoui, M.; Mehri, Sounira; Nakbi, Amel; Hammami, S.; Chaaba, R.; Hamda, Khaldoun Ben; Betbout, Fethi; Frih, M.; Hammami, Mohamed

doi:10.5772/24532

Cited by 1 publication

(3 citation statements)

References 83 publications

(59 reference statements)

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“…It was found that HTLase activity was statistically significantly low in the patient group compared to the control group, and Hcy and oxidized LDL levels were significantly elevated in the patient group. It was reported that the increase in Hcy levels in diabetic patients was due to a decrease in HTLase activity and elevated Hcy levels in diabetic patients would impair lipid metabolism in particular by contributing to the formation of oxidized LDL and therefore accompany atherosclerosis-related complications (33). In our study, no statistical significance was found between plasma Hcy levels in both group II and group III (p>0.05).…”

Section: Discussioncontrasting

confidence: 71%

“…Koubaa et al (33) examined plasma total Hcy levels, HTLase activity, lipid panel (LDL, HDL, TG, Total Cholesterol), lipoprotein (ApoA1 and ApoB) and oxidized LDL levels of diabetic patient group and nondiabetic healthy volunteers. It was found that HTLase activity was statistically significantly low in the patient group compared to the control group, and Hcy and oxidized LDL levels were significantly elevated in the patient group.…”

Section: Discussionmentioning

confidence: 99%

“…Kosaka et al (32) evaluated HTLase activity in patients with T2DM and argued that increased carotid intima-media thickness in patients with T2DM was inversely correlated with HTLase activity, and a reduction in serum HTLase activity could provide data about the status of atherosclerosis in patients with T2DM (32). Koubaa et al (33) examined plasma total Hcy levels, HTLase activity, lipid panel (LDL, HDL, TG, Total Cholesterol), lipoprotein (ApoA1 and ApoB) and oxidized LDL levels of diabetic patient group and nondiabetic healthy volunteers. It was found that HTLase activity was statistically significantly low in the patient group compared to the control group, and Hcy and oxidized LDL levels were significantly elevated in the patient group.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of paraoxonase, arylesterase, and homocysteine thiolactonase activities in patients with diabetes and incipient diabetes nephropathy

Ayan¹,

Şeneş²,

Çayci³

et al. 2019

Journal of Medical Biochemistry

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Summary Background The aim of this study is to examine the relationship among the changes in activities of paraoxonase (PON), arylesterase (ARE) and homocysteine thiolactonase (HTLase) enzyme having antioxidant properties and the development of diabetic nephropathy (DN), one of the most common complications of diabetes. Methods Normoalbuminuric type-2 diabetic patients (Group II, n=100), microalbuminuric type 2 diabetic patients (Group III, n=100) and the control group (Group I, n=100) were included in the study. The age and gender of the patient groups matched with the age and gender of the control group. HTLase, PON and ARE enzyme activities were measured by the spectrophotometric method using a g-thiobutyrinolactone, paraoxon, and phenylacetate substrates respectively. In this study, an autoanalyzer application was developed in order to measure HTLase enzyme activity for the first time. Results Serum HTLase, ARE and PON activities of Group III and Group II were significantly low compared to HTLase, ARE and PON results of Group I (p<0.05). Conclusions Based on our results, PON, ARE and HTLase enzyme activities were found to be decreased due to the increase in the degree of DN.

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Section: Discussioncontrasting

confidence: 71%

Section: Discussionmentioning

confidence: 99%