Interactions between the gut microbiome, dietary restriction, and aging in genetically diverse mice
Lev Litichevskiy,
Maya Considine,
Jasleen Gill
et al.
Abstract:SummaryThe intestinal microbiome changes with age, but the causes and consequences of microbiome aging remain unclear. Furthermore, the gut microbiome has been proposed to mediate the benefit of lifespan- extending interventions such as dietary restriction, but this hypothesis warrants further exploration. Here, by analyzing 2997 metagenomes collected longitudinally from 913 deeply phenotyped, genetically diverse mice, we provide new insights into the interplay between the microbiome, aging, dietary restrictio… Show more
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