Interactions between Stone-Forming Calcific Crystals and Macromolecules

Khan, Saeed R.

doi:10.1159/000283025

Cited by 75 publications

(61 citation statements)

References 66 publications

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“…3 In the present study, 0.75% v/v ethylene glycol was administered orally for 14 days and till 28 th day to induce urolithiasis in the curative and preventive study group of CaOX crystals were almost absent or dissolved or inhibited the aggregation to a greater extent. Urine flow gets obstructed due to the stones in the urinary system which results in decreased glomerular filtration rate.…”

Section: Discussionmentioning

confidence: 77%

“…2 Stone formation is a complex process and involves several physicochemical events which start with crystal nucleation, super saturation, aggregation, and ending with retention within the urinary tract. 3 Super saturation of urine depends upon factors such as pH of urine, concentration of stone forming constituents, ionic strength and complex formation of the constituents. An individual's ability to promote or prevent urolithiasis depends upon various substances present in the body which have effect on one or more of the above factors.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Antiurolithiatic Potentials of Hydro-Alcoholic Extract of Cucumis sativus L.

Pethakar¹,

Hurkadale²,

Hiremath³

2017

IJPER

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Introduction: Cucumis sativus fruits are claimed for their antiurolithiatic activity in traditional system of medicine. Materials and Methods: Present study was undertaken to evaluate lithotryptic effect using hydro-alcoholic extract of Cucumis sativus (HCS). Ethylene glycol (0.75% v/v) was used to induce calculi in Wistar albino rats. Assessed various parameters like, Biochemical, Histopathological and routine urine analysis. Results: Treatment with preventive and curative doses of HCS was found to exert dose dependent antiurolithiatic action. Increased urine volume in HCS treated groups as compared to diseased group was indicative of diuretic property. Elevated calcium, phosphate and oxalate levels in diseased group animal were found to be decreased in animals treated with HCS. Increased levels of serum creatinine, BUN and uric acid were considerably brought down towards normal values in proportion to HCS doses administered. Histopathology of kidney reveals severe renal damage due toperformed crystals. Animals treated with HCS showed remarkable recovery, suggestive of prevention of nucleation and aggregation of stone forming components. Conclusion: It can be concluded that, results are supportive to claims made. The exact mechanism of antiurolithiatic effect may further needs to be studied.

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Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Evaluation of Antiurolithiatic Potentials of Hydro-Alcoholic Extract of Cucumis sativus L.

Pethakar¹,

Hurkadale²,

Hiremath³

2017

IJPER

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show abstract

“…1C), with a thick fibrillar network that connects each hair cell stereociliary bundle to the otolith, but is predicted to have similar biochemical complexity (Khan and Drescher, 1990). Organic substances, including acidic proteins, glycosaminoglycans (GAGs), and proteoglycans, are essential to regulate crystal growth (Addadi et al, 1989;Khan, 1997) and have been identified in both otoliths (Borelli et al, 2003b) and otoconia (Tachibana and Morioka, 1992). Sulfated GAGs may play a crucial role in locally increasing Ca 2+ concentration at the site of biomineralization, as is discussed in more detail below.…”

Section: Make and Export The Matrix Proteins Correctlymentioning

confidence: 99%

Mixing model systems: Using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development

Hughes

Thalmann

et al. 2006

Brain Research

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Human vestibular dysfunction is an increasing clinical problem. Degeneration or displacement of otoconia is a significant etiology of age-related balance disorders and Benign Positional Vertigo (BPV). In addition, commonly used antibiotics, such as aminoglycoside antibiotics, can lead to disruption of otoconial structure and function. Despite such clinical significance, relatively little information has been compiled about the development and maintenance of otoconia in humans. Recent studies in model organisms and other mammalian organ systems have revealed some of the proteins and processes required for the normal biomineralization of otoconia and otoliths in the inner ear of vertebrates. Orchestration of extracellular biomineralization requires bringing together ionic and proteinaceous components in time and space. Coordination of these events requires the normal formation of the otocyst and sensory maculae, specific secretion and localization of extracellular matrix proteins, as well as tight regulation of the endolymph ionic environment. Disruption of any of these processes can lead to the formation of abnormally shaped, or ectopic, otoconia, or otoconial agenesis. We propose that normal generation of otoconia requires a complex temporal and spatial control of developmental and biochemical events. In this review, we suggest a new hypothetical model for normal otoconial and otolith formation based on matrix vesicle mineralization in bone which we believe to be supported by information from existing mutants, morphants, and biochemical studies.

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“…[1] Urolithiasis is a complex process that results from a succession of several physico-chemical events including supersaturation, nucleation, growth, aggregation, and retention within renal tubules. [2] Epidemiological data collected over several decades showed that the majority of stones (up to 80%) are composed mainly of calcium oxalate (CaOx). [3] Urine is always supersaturated with common stone forming minerals.…”

Section: Introductionmentioning

confidence: 99%

Effect of Hordeum vulgare Linn. Seeds on glycolic acid induced urolithiasis in rats

Jignesh¹,

Bharat²,

Sandip³

et al. 2012

Phcog Commn

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Interactions between Stone-Forming Calcific Crystals and Macromolecules

Cited by 75 publications

References 66 publications

Evaluation of Antiurolithiatic Potentials of Hydro-Alcoholic Extract of Cucumis sativus L.

Evaluation of Antiurolithiatic Potentials of Hydro-Alcoholic Extract of Cucumis sativus L.

Mixing model systems: Using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development

Effect of Hordeum vulgare Linn. Seeds on glycolic acid induced urolithiasis in rats

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