Interactions between SOX factors and Wnt/β‐catenin signaling in development and disease

Kormish, Jay D.; Sinner, Débora; Zorn, Aaron M.

doi:10.1002/dvdy.22046

Cited by 240 publications

(222 citation statements)

References 109 publications

Supporting

Mentioning

209

Contrasting

Order By: Relevance

“…It has been reported that SOX factors impact tumorigenesis by modulating β-catenin/T cell factor (TCF) activity and the expression of oncogenic Wnt target genes such as Cyclin-D1 and c-Myc. For example, SOX-17 represses β-catenin/TCF, while SOX4 enhances their transcriptional activity (Kormish et al 2010). Our cDNA microarray result demonstrated up-regulation of SOX-4 and down-regulation of SOX-17 in ESCC, which is similar to Kormish's report and suggests that Sox-Wnt interactions may be involved in ESCC development.…”

Section: Discussionsupporting

confidence: 79%

Identification of Distinct Gene Expression Profiles between Esophageal Squamous Cell Carcinoma and Adjacent Normal Epithelial Tissues

Tao

Chai

et al. 2012

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Esophageal squamous cell carcinoma (ESCC) is a predominant type of esophageal cancer, which is a malignant tumor originating from the esophageal mucosa or gland and is aggressive with poor prognosis. Identification of new gene expression patterns would be helpful for providing new targets for the early detection and treatment of ESCC patients. In the present study, we employed cDNA array technology to compare gene expression profiles between ESCC tissues and adjacent normal epithelial tissues from ESCC patients. There was at least a 4-fold change in the expression levels of 72 genes that were significantly increased and 107 genes that were decreased in ESCC compared with normal esophageal epithelium. Among them, genes known to be involved in ESCC were found, including matrix metalloproteinases, transcription factors SOX-4 and SOX-17, the Wingless-type MMTV integration site family member 2, and cell cycle regulators. Moreover, we have newly identified the two genes that are down-regulated in ESCC: monoamine oxidase A, an enzyme that catalyzes monoamines oxidation and 15-hydroxyprostaglandin dehydrogenase [NAD+], a prostaglandin-synthesizing enzyme that physiologically antagonizes COX-2. Likewise, we found the three genes that are up-regulated in ESCC: CD7, a cell surface glycoprotein member of the immunoglobulin superfamily, LIM-domain kinase 1, a small subfamily with an unique combination of two N-terminal LIM motifs and a C-terminal protein kinase domain, and TTK protein kinase, a previously unidentified member of the kinase family. These newly identified genes may be involved in the progression of the tumor and/or represent properties specific to ESCC.

show abstract

Section: Discussionsupporting

confidence: 79%

Identification of Distinct Gene Expression Profiles between Esophageal Squamous Cell Carcinoma and Adjacent Normal Epithelial Tissues

Tao

Chai

et al. 2012

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…In contrast, such findings were not observed in 10 normal and 15 AH lesions investigated. 34 we anticipated a formation of active transcriptional complexes containing b-catenin, TCF4, and Sox4, as demonstrated with combination of b-catenin and p300, 18 but such associations proved to be rare events in Em Ca cells. Interestingly, the three proteins are unable to form stable complexes in vitro, 32 and it was recently reported that transactivation of b-catenin signaling induced by Sox4 was due to stabilization of the b-catenin protein, rather than through induction of b-catenin transcription.…”

Section: Hypermethylation Of Sox7 Promoter In Em Casmentioning

confidence: 90%

Sox4 functions as a positive regulator of β-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas

Saegusa

Hashimura

Kuwata

2012

Laboratory Investigation

View full text Add to dashboard Cite

Sox factors function as either activators or repressors of b-catenin/TCF transcription depending on the cellular context and associated interacting proteins. Our previous study provided evidence that alteration in b-catenin signaling is an essential event during transdifferentiation toward the morular phenotype of endometrial carcinomas (Em Cas). Here, we focused on related functional roles of Sox factors. Of eight Sox factors investigated, Sox4 could enhance b-catenin/TCF4 transcription, through upregulation of TCF4 at the transcription level, without any direct b-catenin association. Cells stably overexpressing Sox4 showed significant decreases in proliferation rate, along with increases in expression of p21 WAF1 , as well as TCF4, in contrast to increased cell growth observed with knockdown. Of these factors, only Sox7 could transcriptionally upregulate Sox4 expression, but it also resulted in not only inhibition of Sox4-meditated activation of b-catenin/TCF4-driven transcription, but also repression of its own promoter activity, indicating the existence of very complex feedback loop for Sox-mediated signal cascades. Finally, Sox4 immunoreactivity was frequently pronounced in morular lesions of Em Cas, the expression being positively correlated with status of b-catenin, TCF4, and Sox7, and inversely with cell proliferation. These data therefore suggest that Sox4 may serve as a positive regulator of b-catenin signaling through alteration in TCF4 expression during morular differentiation of Em Ca cells, leading to inhibition of cell proliferation. In addition, Sox7 may also participate in the process, having complex roles in modulation of signaling.

show abstract

“…Downregulation of Sox10 by promoter methylation has also been detected in gastric cancer tissues [112] . Sox (SRY-related-HMG-box) familiy members are transcription factors that regulate canonical Wnt signaling through different mechanisms, including protein-protein interactions and binding to Wnt-target gene promoters [151] . Sox10 is an important DNA binding transcription factor that recruits b-catenin to repress Wnt/b-catenin signaling in cancer progression [112] .…”

Section: Loss Of Wnt Repressor Function In Gastric Cancermentioning

confidence: 99%

Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review

Chiurillo

2015

WJEM

260

219

View full text Add to dashboard Cite

Gastric cancer remains one of the most common cancers worldwide and one of the leading cause for cancerrelated deaths. Gastric adenocarcinoma is a multifactorial disease that is genetically, cytologically and architecturally more heterogeneous than other gastrointestinal carcinomas. The identification of specific membrane, intracellular, and extracellular components of the Wnt pathway has revealed potential targets for gastric cancer therapy. High-throughput "omics" approaches will help in the search for Wnt pathway antagonist in the near future.

show abstract

Interactions between SOX factors and Wnt/β‐catenin signaling in development and disease

Cited by 240 publications

References 109 publications

Identification of Distinct Gene Expression Profiles between Esophageal Squamous Cell Carcinoma and Adjacent Normal Epithelial Tissues

Identification of Distinct Gene Expression Profiles between Esophageal Squamous Cell Carcinoma and Adjacent Normal Epithelial Tissues

Sox4 functions as a positive regulator of β-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas

Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review

Contact Info

Product

Resources

About